A Rat Model for Capsular Contracture: The Effects of Surface Texturing

Clugston, Patricia A.; Perry, Larry; Hammond, Dennis C.; Maxwell, G. Patrick

doi:10.1097/00000637-199412000-00005

Cited by 42 publications

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“…It deserves attention the possibility of an oral drug for the treatment of a complication that has serious physical, Recent research has shown that its use in animals 10,13,14 and clinical trials 8,12,[15][16][17] In this study, the option for silicone prostheses and not saline ones was due to the greater incidence of capsular contracture found in the use of the former 9 ; the observation time (three months) was based on other studies with rats, which showed that most of the capsular contractures occurred during this period 21 .…”

Section: Discussionmentioning

confidence: 99%

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Effect of zafirlukast on capsular contracture around silicone implants in rats

et al. 2012

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PURPOSE:To evaluate the effect of zafirlukast on capsular contracture around silicone implants by measuring the pressure within the implant, using a rat experimental model. METHODS: Forty adult female Wistar rats were used. Each one received two silicone implants, one with smooth-surface and the other with textured-surface. They were randomly divided into four groups (n=10). The rats of control group I were sacrificed after the implants. The remaining animals were subjected to a daily regimen of intra-peritoneal injection for a period of 90 days and they were distributed as follows: control group II received 0.9% physiological saline solution; experimental group I received zafirlukast 1.25 mg/kg; and experimental group II received zafirlukast 5 mg/kg. The measurement of intra-implant pressure of control group I was determined on the surgery day and in other groups on the ninetieth day, after being sacrificed. RESULTS: In the evaluation of textured implants there was an increase of internal pressure in the control group II, and there was no increase in the experimental groups. Compared to the controls there were not significant differences in smooth implants. CONCLUSION: Zafirlukast reduced the risk of developing capsular contracture around silicone implants with textured surface. Key words: Breast Implants. Implant Capsular Contracture. Leukotriene Antagonists. Rats. RESUMO OBJETIVO: Avaliar o efeito do zafirlukast na contratura capsular ao redor de implantes de silicone, através da aferição da pressão intra-implante, utilizando-se um modelo experimental de ratos. MÉTODOS: Quarenta ratos fêmeas Wistar foram utilizados. Cada um recebeu dois implantes de silicone, sendo um com superfície lisa e outro texturizada. Foram divididos aleatoriamente em quatro grupos (n=10). Os ratos do grupo controle I foram sacrificados após o implante. O restante dos animais foi submetido a um regime diário de injeção intraperitoneal por um período de 90 dias e foram distribuídos: grupo controle II recebeu solução salina fisiológica 0,9%, grupo experimental I recebeu zafirlukast 1,25 mg/kg, e grupo experimental II recebeu zafirlukast 5 mg/kg. O grupo controle II recebeu solução salina; grupo experimental I, 1,25 mg/kg/dia de zafirlukast; grupo experimental II, 5mg/kg/dia de zafirlukast. A aferição da pressão intra-implante do grupo controle I foi averiguada no dia do ato operatório, e nos outros grupos no nonagésimo dia, após serem sacrificados. RESULTADOS: Na avaliação dos implantes texturizados houve aumento da pressão interna no grupo controle II e, não se observou aumento nos grupos experimentais. Na comparação com os controles não foram observadas diferenças significativas nos implantes lisos. CONCLUSÃO: O Zafirlukast reduziu o risco de desenvolver contratura capsular em torno de implantes de silicone com superfície texturizada. Descritores: Implantes de Mama. Contratura Capsular em Implantes. Antagonistas de Leucotrienos. Ratos.

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Section: Discussionmentioning

confidence: 99%

“…As for the method of measuring the complacency of the capsule, it was chosen the method of infusion liquid which had been described by other authors [21][22][23] . The use of pressure measurement system was necessary because it seems to be the most objective method to assess capsular contracture.…”

Section: Discussionmentioning

confidence: 99%

Effect of zafirlukast on capsular contracture around silicone implants in rats

et al. 2012

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“…According to Clugston et al, 29 some characteristics of experimental research with small animals differ greatly from those of experimental research with humans due to the ample mobility of the panniculus carnosus area, particularly in rat and rabbit tissues. Pigs have a well-differentiated epidermal structure, with a thick dermis that is rich in elastic fibers and relatively attached to deeper tissues.…”

Section: Discussionmentioning

confidence: 99%

“…These findings differ from those of other experimental works in rats and rabbits that demonstrated the opposite effect. 23,[27][28][29]32 Concerning the genesis of capsular contracture, the concentration of collagen has been shown to be the main component in the fibrosis process. 36 The picrosirius polarization method has permitted some authors to quantify the state of collagen aggregation and to describe the natural history of the fibrosis process in diseases and some experimental models.…”

Section: Discussionmentioning

confidence: 99%

“…Ginsbach et al 25 inferred that the capsular contracture may occur because of an inelastic characteristic of collagen fibers with parallel orientation. McCoy et al 26 observed an increase in the production of collagen (with no altered ratio of type III and type I collagens in the breast capsular contracture) when compared with noncontracted breast capsules and normal breasts; moreover, experimental studies of rats and rabbits 16,23,[27][28][29] were not capable of revealing significant results because of their contradictory results when compared with clinical findings.…”

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The Composition and Behavior of Capsules around Smooth and Textured Breast Implants in Pigs

Minami

Koh

Ferreira

et al. 2006

Plastic and Reconstructive Surgery

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The greater incidence of capsular contracture in smooth implants was correlated with the progressive increase in total capsule thickness, due to a higher concentration of collagenous fibers, when compared with textured implants (p = 0.011; mean difference, 6.61), and a higher concentration of thick fibers (p = 0.034; average, >5.51 percentage points per field of thick fibers than the textured implants in all periods). Pigs are good animal models for studying the healing process after breast augmentation with implants.

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Quantifying shape changes of silicone breast implants in a murine model using in vivo micro‐CT

et al. 2016

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A major complication of silicone breast implants is the formation of a capsule around the implant known as capsular contracture which results in the distortion of the implant. Recently, a mouse model for studying capsular contracture was examined using micro-computed tomography (micro-CT), however, only qualitative changes were reported. The aim of this study was to develop a quantitative method for comparing the shape changes of silicone implants using in vivo micro-CT. Mice were bilaterally implanted with silicone implants and underwent ionizing radiation to induce capsular contracture. On day 28 post-surgery mice were examined in vivo using micro-CT. The reconstructed cross-section images were visually inspected to identify distortion. Measurements were taken in 2D and 3D to quantify the shape of the implants in the normal (n = 11) and distorted (n = 5) groups. The degree of anisotropy was significantly higher in the distorted implants in the transaxial view (0.99 vs. 1.19, p = 0.002) and the y-axis lengths were significantly shorter in the sagittal (9.27 mm vs. 8.55 mm, p = 0.015) and coronal (9.24 mm vs. 8.76 mm, p = 0.031) views, indicating a deviation from the circular cross-section and shortening of the long axis. The 3D analysis revealed a significantly lower average thickness (sphere-fitting method) in distorted implants (6.86 mm vs. 5.49 mm, p = 0.002), whereas the volume and surface area did not show significant changes. Statistically significant differences between normal and distorted implants were found in 2D and 3D using distance measurements performed via micro-CT. This objective analysis method can be useful for a range of studies involving deformable implants using in vivo micro-CT. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1447-1452, 2017.

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A Rat Model for Capsular Contracture: The Effects of Surface Texturing

Cited by 42 publications

References 0 publications

Effect of zafirlukast on capsular contracture around silicone implants in rats

Effect of zafirlukast on capsular contracture around silicone implants in rats

The Composition and Behavior of Capsules around Smooth and Textured Breast Implants in Pigs

Quantifying shape changes of silicone breast implants in a murine model using in vivo micro‐CT

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