A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption

Holgate, Joan; Shariff, Masroor; Mu, Erica W. H.; Bartlett, Selena E.

doi:10.3389/fnbeh.2017.00029

Cited by 36 publications

(33 citation statements)

References 63 publications

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“…More research needs to be conducted to disentangle these explanations. Notwithstanding the mechanism, this procedure reliably maintains ethanol consumption at clinically relevant levels (Holgate et al, 2017).…”

Section: Discussionmentioning

confidence: 93%

“…Thus, consistent self-administration prompted by negative incentive shifts was clearly demonstrated in each rat throughout the study. Moreover, the levels of ethanol intake were clinically relevant such that obtained levels exceed criteria previously quantified as binge drinking (Holgate et al, 2017).…”

Section: Discussionmentioning

confidence: 94%

“…4. Notwithstanding the mechanism, this procedure reliably maintains ethanol consumption at clinically relevant levels (Holgate et al, 2017). Results are shown in six 5-min blocks across the 30-min session.…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, the levels of ethanol intake were clinically relevant such that obtained levels exceed criteria previously quantified as binge drinking (Holgate et al, 2017). Rats consumed sweetened ethanol and ethanol for 30 sessions combined during Experiment 1.…”

Section: Discussionmentioning

confidence: 97%

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Effects of negative incentive shifts in food reward on rats' consumption of concurrent ethanol solutions

Sawyer

Galuska

Cutright

et al. 2019

J Exper Analysis Behavior

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Frustration stress, typically operationalized as the unexpected loss of reinforcement, has been shown to engender substance use. Abrupt reductions in reinforcer magnitude likely also function as frustration stressors. These negative incentive shifts were previously shown to produce tap-and sweetened-water drinking in rats. The purpose of this study was to investigate whether these shifts in food reward would occasion oral ethanol self-administration. Nine male Long-Evans rats operated on a two-component multiple fixed-ratio schedule with signaled components producing either a large (4 pellets) or small (1pellet) reinforcer. Components were pseudorandomly arranged to present 4 transitions between past and upcoming reinforcer magnitudes: small-to-large, small-to-small, large-to-large, and large-to-small (negative incentive shift). Experiment 1 investigated the effects of negative incentive shifts on consumption of concurrent, freely available 10% sucrose, 10% sucrose plus 10% ethanol, and following sucrose fading, 10% ethanol. Experiment 2 entailed continuation of schedule contingencies with a dose manipulation of 4 ethanol concentrations (0, 5, 10, and 20%) to assess dose-dependent differences in transition-type control and consumption. A lever-press extinction condition was then conducted with 10% ethanol availability. In this novel model of frustration stress, negative incentive shifts prompted ethanol self-administration at each dose investigated, whereas the other transitions did not.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Effects of negative incentive shifts in food reward on rats' consumption of concurrent ethanol solutions

Sawyer

Galuska

Cutright

et al. 2019

J Exper Analysis Behavior

View full text Add to dashboard Cite

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“…A direct correlation between BEC (mg/dl) and EtOH intake (g/kg/hour) was detected (not shown) that agrees with previous reports (Holgate et al . ).…”

Section: Methodsmentioning

confidence: 97%

Cognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence

et al. 2018

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Binge drinking (BD) is a common pattern of ethanol (EtOH) consumption by adolescents. The brain effects of the acute EtOH exposure are well-studied; however, the long-lasting cognitive and neurobehavioral consequences of BD during adolescence are only beginning to be elucidated. Environmental enrichment (EE) has long been known for its benefits on the brain and may serve as a potential supportive therapy following EtOH exposure. In this study, we hypothesized that EE may have potential benefits on the cognitive deficits associated with BD EtOH consumption. Four-week-old C57BL/6J male mice were exposed to EtOH following an intermittent 4-day drinking-in-the-dark procedure for 4 weeks. Then they were exposed to EE during EtOH withdrawal for 2 weeks followed by a behavioral battery of tests including novel object recognition, novel location, object-in-place, rotarod, beam walking balance, tail suspension, light-dark box and open field that were run during early adulthood. Young adult mice exposed to EE significantly recovered recognition, spatial and associative memory as well as motor coordination skills and balance that were significantly impaired after adolescent EtOH drinking with respect to controls. No significant permanent anxiety or depressive-like behaviors were observed. Taken together, an EE exerts positive effects on the long-term negative cognitive deficits as a result of EtOH consumption during adolescence.

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