A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

Xiao, Qin; Chen, Lianzhou; Luo, Hui; Li, Hongmei; Kong, Qingming; Jiao, Fei; Pang, Shaojun; Zhang, Ming; Lan, Feifei; Fan, Wenguo; Luo, Hui; Tao, Tao; Zhu, Xiao

doi:10.1186/s12885-018-4551-y

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…In the present study, we first demonstrated that CHD5 was differentially expressed between most cancer tissues and the adjacent normal tissues, which suggested that CHD5 was a potential tumor suppressor gene in most cancers. The above finding was consistent with previously reported results regarding the differential expression of CHD5 in different cancers, including neuroblastoma, melanoma, hepatocellular carcinoma, non-small cell lung cancer, and head and neck squamous cell carcinoma [ 20 , 21 , 22 , 23 , 24 ]. Our results also showed that the expression of CHD5 was upregulated in some cancer types.…”

Section: Discussionsupporting

confidence: 93%

Pan-Cancer Analysis Identifies CHD5 as a Potential Biomarker for Glioma

Shao

Luo

et al. 2022

IJMS

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The chromodomain helicase DNA binding domain 5 (CHD5) is required for neural development and plays an important role in the regulation of gene expression. Although CHD5 exerts a broad tumor suppressor effect in many tumor types, its specific functions regarding its expression levels, and impact on immune cell infiltration, proliferation and migration in glioma remain unclear. Here, we evaluated the role of CHD5 in tumor immunity in a pan-cancer multi-database using the R language. The Cancer Genome Atlas (TCGA), Genotype Tissue Expression (GTEx), and Cancer Cell Lines Encyclopedia (CCLE) datasets were utilized to determine the role of CHD5 in 33 types of cancers, including the expression level, prognosis, tumor progression, and immune microenvironment. Furthermore, we explored the effect of CHD5 on glioma proliferation and migration using the cell counting kit 8 (CCK-8) assay, transwell assays and western blot analysis. The findings from our pan-cancer analysis showed that CHD5 was differentially expressed in the tumor tissues as compared to the normal tissues. Survival analysis showed that CHD5 was generally associated with the prognosis of glioblastoma (GBM), low Grade Glioma (LGG) and neuroblastoma, where the low expression of CHD5 was associated with a worse prognosis in glioma patients. Then, we confirmed that the expression level of CHD5 was associated with tumor immune infiltration and tumor microenvironment, especially in glioma. Moreover, si-RNA mediated knockdown of CHD5 promoted the proliferation and migration of glioma cells in vitro. In conclusion, CHD5 was found to be differentially expressed in the pan-cancer analysis and might play an important role in antitumor immunity. CHD5 is expected to be a potential tumor prognostic marker, especially in glioma.

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Section: Discussionsupporting

confidence: 93%

Pan-Cancer Analysis Identifies CHD5 as a Potential Biomarker for Glioma

Shao

Luo

et al. 2022

IJMS

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“…Zhu et al, In 2018, studying the CHD5 gene, showed that rs12564469‐rs9434711 was significantly associated with the prediction of hepatocellular carcinoma (HCC) 19 . A potential association was observed between the risk of HCC and CHD5 polymorphisms—rs2273032, rs12067480, and rs9434741—in a case–control study on the Chinese population 20 . In one study, rs1883603, rs9434741, and rs17436816 polymorphisms of the CHD5 gene in endometriosis were examined, and it was found that rs9434741 was significantly associated with endometriosis 21 .…”

Section: Discussionmentioning

confidence: 99%

“…19 A case-control study confirmed the potential association between the risk of hepatocellular carcinoma and CHD5 polymorphisms rs2273032, rs12067480, and rs9434741 in the Chinese population. 20 Also, rs9434741 of the CHD5 gene was significantly associated with endometriosis in women. 21 The Hershlag study showed that the CHD5 rs538186680 was significantly higher in infertile males than in controls, so idiopathic causes of infertility may be associated with CHD5 disorders.…”

Section: Introductionmentioning

confidence: 95%

“…Zhu et al, in 2018, showed that rs12564469 and rs9434711 in the CHD5 gene are significantly associated with diagnosing hepatocellular carcinoma 19 . A case–control study confirmed the potential association between the risk of hepatocellular carcinoma and CHD5 polymorphisms rs2273032, rs12067480, and rs9434741 in the Chinese population 20 …”

Section: Introductionmentioning

confidence: 96%

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The possible impact of DNA‐binding chromodomain‐helicase 5 polymorphisms on male infertility: A case–control study

Moudi

Asemi-Rad

Sheibak

et al. 2023

J of Obstet and Gynaecol

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Background Chromodomain‐helicase 5 (CHD5) is a conventional tumor‐suppressing gene in many tumors. The CHD5 gene, as a key factor in the chromatin density process during sperm maturation, can affect the risk of infertility. This study aimed to determine whether CHD5 variants contribute to the risk of male infertility. Methods Gene variants were identified using tetra primer‐ARMS‐PCR method on nonobstructive azoospermia and severe oligozoospermia in a case–control study. SPSS software 20 (SPSS Inc. Chicago, IL, USA) was used for data recording and statistical analysis. Results In the codominant pattern, the rs12067480 TT variant versus CC significantly increased the risk of disease, and also, in the recessive pattern, TT variant versus CC + CT and T allele versus C. The rs2273032 variant was associated with the risk of infertility in codominant pattern AA versus GG and recessive pattern AA versus GG + GA and allele. We discovered that the rs12067480 T and rs2273032 A alleles increase the risk of male infertility. Also, the interaction of the CT/GA, CT/AA, TT/GA genotypes and rs12067480T/rs2273032A and rs12067480T/rs2273032G haplotypes significantly increased the risk of infertility. Conclusions Our results suggest that the CHD5 gene polymorphisms contribute to the risk of male infertility. Our findings can be valuable in improving the diagnosis and treatment of infertility.

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“…CHD5 is one of the nine members of the CHD‐binding enzymes and belongs to the snf2 DNA helicase/methylasesuperfamily. CHD5 is composed of 42 exons that encode a 223 kDa protein – which encodes a protein of 1954 amino acids(Xiao et al, 2018). CHD5 is required for sperm development and defects in sperm chromatin density can lead to major problems in male fertility (Zhuang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

CHD5 gene (rs9434741) might be a genetic risk factor for infertility in non‐obstructive azoospermia and severe oligozoospermia

et al. 2022

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Inability to conceive is one of the health concerns. Chromodomain helicase DNA-binding protein5 (CHD5) gene is a major regulator in the replacement of histone proteins with protamines, the chromatin remodelling in spermatogenesis process. Thus, functional SNPs in this gene can disrupt sperm development. This study aimed to investigate the relationship between CHD5 polymorphism (rs9434741) and male infertility. This case-control study was conducted on 103 infertile and 121 fertile men. CHD5 polymorphism rs9434741 was tested using T-ARMS-PCR to investigate its association with male infertility. The presence of G allele caused 1.52 fold increase (OR = 1.52, 95% CI = 1.09-2.31 and p = 0.019) in infertility susceptibility in the patient group. GG genotype and (AG+GG) were significantly related to the increased risk of infertility (OR = 3.13, 95% CI = 1.26-7.76, p = 0.013; OR = 2.72, 95% CI = 1.35-5.47), respectively. Significant differences were observed between genotypes in NOA and SO groups compared to the control group (p = 0.029). Sperm count and total motility were significantly different among three genotypes in infertile men and the control group (p < 0.001). Analysis of genotypes and alleles frequency indicated statistically significant differences between the patient and control groups (p < 0.05). This study showed that CHD5 polymorphism (rs9434741) could be associated with the risk of male infertility. It is recommended to conduct further studies on different populations.

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A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

Cited by 8 publications

References 36 publications

Pan-Cancer Analysis Identifies CHD5 as a Potential Biomarker for Glioma

Pan-Cancer Analysis Identifies CHD5 as a Potential Biomarker for Glioma

The possible impact of DNA‐binding chromodomain‐helicase 5 polymorphisms on male infertility: A case–control study

CHD5 gene (rs9434741) might be a genetic risk factor for infertility in non‐obstructive azoospermia and severe oligozoospermia

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