A Rare Cause of Distal Bile Duct Stenosis

Stoeckler, F.; Hagmüller, E.; Rumpelt, H. J.; Weickert, U.

doi:10.1007/s12029-008-9029-8

Cited by 3 publications

(2 citation statements)

References 14 publications

(14 reference statements)

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“…1997 [ 19 ] 1 Distal bile duct Pancreaticoduodenectomy Stoeckler et al . 2007 [ 18 ] 1 Distal bile duct Pancreaticoduodenectomy Rego et al . 2009 [ 17 ] 2 Ampulla of Vater, intraluminal Surgery, observation …”

Section: Discussionmentioning

confidence: 99%

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Metastatic breast cancer mimicking a hilar cholangiocarcinoma: case report and review of the literature

et al. 2014

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Background/aimsBreast cancer is the most common tumor in women and the first cause of death for malignancy in the female population. Bile ducts are not among the common sites of metastasis from breast cancer; few cases of obstructive jaundice due to metastatic breast cancer have been described in the literature and they mostly resulted from widespread liver metastases that eventually involved the bile ducts. We report an exceptional case of metastatic infiltration of the extrahepatic bile ducts in absence of liver metastases.Case presentationA 56-year-old woman who had undergone a right mastectomy 13 years earlier due to infiltrating ductal breast cancer and had remained tumor free, presented at a follow-up examination with obstructive jaundice.Imaging (computed tomography, magnetic resonance and endoscopic retrograde cholangiopancreatography) scans showed features that were suggestive of a primary tumor of the extrahepatic bile duct. At surgery, the intraoperative findings were also those of a tumor of the bile duct, however, an histological examination showed no evidence of malignancy in the mucosa, but did shown an infiltration of the external wall from adenocarcinoma. Immunohistochemistry analysis demonstrated that the tumor was metastatic breast cancer.ConclusionsIndeterminate stenosis of the extrahepatic bile ducts should be examined with suspicion in women with a history of breast cancer, and bile duct metastases are to be considered among the possible diagnoses. A differential diagnosis from cholangiocarcinoma is of paramount importance and mainly relies on pathology.

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Section: Discussionmentioning

confidence: 99%

“…[ 19 ] and Stoeckler et al . [ 18 ] it originated from the Ampulla of Vater and infiltrated the bile duct wall.…”

Section: Discussionmentioning

confidence: 99%

Metastatic breast cancer mimicking a hilar cholangiocarcinoma: case report and review of the literature

et al. 2014

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Rare sites of breast cancer metastasis: a review

Micco¹,

Santurro²,

Gasparri³

et al. 2019

Transl. Cancer Res.

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Breast cancer (BC) metastasis accounts for the majority of deaths from BC. The rate of metastasis to uncommon sites is on the rise due to the more effective therapy prolonging survival and to the early detection on imaging. The evaluation of patient-reported symptoms is essential in detecting a recurrence as early as possible, which may impact survival. Hence, the knowledge of even the rare sites of BC metastasis is of paramount importance for the clinical interpretation of new symptoms in BC survivors. The term “unusual metastasis” defines a systemic failure with a frequency of ≤1% at each site and according to this unusual metastasis involve the central nervous system, secretory/endocrine organs and glands, internal organs and structures, and gynecological organs. The literature search was performed using the electronic database PubMed up to December 2018, with the following key words: {[rare(Title/Abstract)] OR [ unusual (Title/Abstract)] OR [ unconventional (Title/Abstract)]} AND {[ metastases (Title/Abstract)] OR [ metastasis (Title/Abstract)]} AND {[ breast (Title/Abstract)]} AND {[ cancer (Title/Abstract)] OR [ tumor (Title/Abstract)] OR [ tumour (Title/Abstract)] OR [neoplasm(Title/Abstract)]}. The search was limited to papers in English language. Of the 3,086 papers found, 757 were excluded as reporting animal models, 378 were not in English language, 1 was a duplicate of the same research, 1,414 did not report on BC metastases, 108 were previous review reviews on BC or tumour to tumour metastases; 428 papers were included in this review. Despite the improvements in BC management, most deaths from cancer result from metastases that are resistant to conventional therapies. In general, it is uncommon to find isolated rare metastases, the vast majority of these develops together with metastases in other sites, thus highlighting a worsening systemic disease. However, the early detection of even rare metastases represents the only chance to control the disease and prolong survival while waiting for the development of more effective systemic therapies.

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Rare common bile duct metastasis of breast cancer: A case report and literature review

Tang¹,

Zhao²,

Deng³

et al. 2021

WJGO

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BACKGROUND Breast cancer is the most common tumor in women, and about one-third of cases develop metastatic disease. However, metastatic breast cancer rarely invades the common bile duct (CBD) directly without involving the liver, and involvement of the gastrointestinal tract is rare. Cases of such metastases pose a particular diagnostic challenge. CASE SUMMARY A 55-year-old female presented to the Department of Gastroenterology with complaint of a 2 mo history of right upper abdominal pain accompanied by pain in the right back, aggravated after eating greasy diet. The patient had received a diagnosis of breast cancer 3 years prior. Physical examination showed obvious superficial protuberant erythema on the left neck and chest skin, with slight tenderness and burning sensation. Endoscopic retrograde cholangiopancre-atography showed an obstruction at the end of the CBD. Histopathology of the CBD and symptomatic skin biopsies showed positivity for cytokeratin 7 and trans-acting T-cell-specific transcription factor breast cancer biomarkers. A cancer embolus was also found in the skin vasculature. Accordingly, the diagnosis of breast cancer metastases to the skin and biliary ducts was made. A plastic biliary sent was placed, which relieved the right upper abdominal pain and protected against unnecessary hepatectomy surgery. CONCLUSION Although rare, biliary metastasis should be considered in patients with bile duct stenosis and a history of breast cancer.

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A Rare Cause of Distal Bile Duct Stenosis

Abstract: The metastasis was the only tumor manifestation after mastectomy 12 years ago.

Cited by 3 publications

References 14 publications

Metastatic breast cancer mimicking a hilar cholangiocarcinoma: case report and review of the literature

Metastatic breast cancer mimicking a hilar cholangiocarcinoma: case report and review of the literature

Rare sites of breast cancer metastasis: a review

Rare common bile duct metastasis of breast cancer: A case report and literature review

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