A rare case report on Glanzmann thrombasthenia

Abstract

Glanzmann thrombasthenia (GT) is a rare inherited blood clotting disorder characterized by the impaired function of platelets that are essential for proper blood clotting and can lead to prolonged bleeding time. Patient with GT may experience menorrhagia, easy bruising, purpura, epistaxis, and gingival bleeding. Here, we report a case of a young male, who was presented with complaints of malena, epigastric pain, and generalized weakness. Computed tomography and magnetic resonance imaging showed hemoperitoneum and perihepatic hematoma, respectively. Later, he also developed black-colored stools and occasional cough. Coagulation profile was suggestive of Glanzmann thrombasthenia. The patient was treated symptomatically, and as the conditions improved, the patient was discharged in a stable state of health. Only up to 500 cases were reported regarding GT till this date. As GT is a rare disorder, it needs to be reported in the current clinical setting.

Glanzmann Thrombasthenia: A Case Report of a Rare Inherited Coagulation Disorder Presenting with Traumatic Head Injury

“…Much of the literature has concluded that GT is diagnosed early, in contrast to this study in which the patient had GT newly diagnosed during surgery at the age of 32. Cherian et al 18 detailed a 28-year-old male with GT who received a late diagnosis. Swathi et al 19 identified an 18-year-old female who had a recent diagnosis of GT but had a history of prolonged bleeding after mild trauma, a propensity to bleed, including purpura in areas of easy bruising, gum bleeding, and prolonged bleeding time after abrasions and insect stings.…”