A rare case of sarcoid-like reaction of lymph nodes associated with squamous cell carcinoma of alveolar mucosa

Nag, Shweta; Saraswathi, TR; Sekhar, Ganthimathy; Einstein, A; Sivapathasundharam, B

doi:10.4103/0970-9290.59446

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Nag et al . proposed that the granulomatous reaction and the release of cytokines such as TNF‐α, IL‐2 and IL‐8 might be markers of an immunologically mediated antitumor response.…”

Section: Discussionmentioning

confidence: 99%

“…Antigenloaded dendritic cells produce interleukin 12 (IL-12) and present the antigen to naïve CD4 + T cells, which differentiate into T helper 1 cells, resulting in further maturation of macrophages and granuloma formation (6). Nag et al (7) proposed that the granulomatous reaction and the release of cytokines such as TNF-α, IL-2 and IL-8 might be markers of an immunologically mediated antitumor response.…”

Section: Discussionmentioning

confidence: 99%

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A sarcoidosis‐like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with FGFR1 gene amplification

Wei

Hou

Pan

et al. 2015

Clinical Respiratory J

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Although tumor-induced draining lymph node granulomatous reactions are rare, they did exist in some of the patients. In this case, differential diagnoses with malignant granulomas should be performed carefully to avoid the misdiagnosis of a benign disease. The biological significance of such a granulomatous response in inducing tumor remission or in shielding tumor cells from host lymphocytes remains obscure.

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“…Nag et al . proposed that the granulomatous reaction and the release of cytokines such as TNF‐α, IL‐2 and IL‐8 might be markers of an immunologically mediated antitumor response.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A sarcoidosis‐like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with FGFR1 gene amplification

Wei

Hou

Pan

et al. 2015

Clinical Respiratory J

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Sarcoidosis vs. Sarcoid-like reactions: The Two Sides of the same Coin?

Tchernev

Tana

Schiavone

et al. 2014

Wien Med Wochenschr

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Differentiating between sarcoidosis as an autonomous disease and sarcoid-like reactions requires considerable efforts. The epithelioid cell granuloma is not equivalent to sarcoidosis because it may be identified in a number of infectious and noninfectious disorders, including neoplastic diseases. At the current state of knowledge, accurate distinction between different causes of epithelioid cell granulomas is in many cases not possible. Despite being characteristic of sarcoidosis and sarcoid-like reactions, the epithelioid cell granuloma is not their synonym, as numerous other causes can give rise to such a type of granulomatous infiltrate. Its etiology should be sought through careful additional investigations, including the genetic signature of both conditions.Sarcoid-like reactions may be grouped generally into several subtypes. The differentiation between each one of them requires a certain combination of diagnostic tests. The major objective of these tests is to exclude or to prove the presence of an infectious, tumoral, or immunogenic antigen on the one hand, and to characterize the genetic profile of the affected patients (for example, sarcoidosis-specific genes) on the other. Only thus may one accurately differentiate between the two pathologic conditions described earlier in the abstract.The clear differentiation between sarcoidosis as a separate disease and sarcoid-like pathologies leads to the more precise clarification of the final diagnosis, which may in turn allow for a more appropriate therapy and improvement in the quality of life of the patients. Equating sarcoid granulomas with sarcoidosis can lead to serious consequences in a number of patients. Sadly enough, after scrutinizing the current available data in the world literature, one cannot find criteria to allow such distinction in a high percentage of the investigated cases.This critical review provides a completely new pathogenetic and diagnostic algorithm, helping in the differentiation between the disease sarcoidosis and the sarcoid-like pathologies with different etiology. An update on the inclusion criteria from the ATS/ERS/WASOG (American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders) statement (which at the current state of knowledge seems to be ineffective) for the diagnosis of sarcoidosis is also suggested.In conclusion, molecular mimicry may be seen as the main pathogenic generator not only of sarcoidosis but also of sarcoid-like reactions. A completely new and exact definition of the notion of or the sarcoidosis disease itself will be possible only after 1. defining the genetic risk for the development of sarcoidosis as an autonomous disease and supplementing the sarcoidosis consensus of ATS/ERS/WASOG from 1999 with this important information, and 2. defining the notion of a sarcoid-like reaction and its subforms.

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A rare case of sarcoid-like reaction of lymph nodes associated with squamous cell carcinoma of alveolar mucosa

Cited by 2 publications

References 7 publications

A sarcoidosis‐like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with FGFR1 gene amplification

A sarcoidosis‐like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with FGFR1 gene amplification

Sarcoidosis vs. Sarcoid-like reactions: The Two Sides of the same Coin?

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