A sarcoidosis‐like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with <scp>FGFR</scp>1 gene amplification

Wei, Hailong; Hou, Jun; Pan, Jue; Su, Xiaojie; Li, Li-Qiong; Wang, Xiangdong; Chen, Zhihong

doi:10.1111/crj.12306

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Therefore, it has been suggested to include tumors in the list of differential diagnosis of granulomatous inflammation of unknown origin (12,13).…”

Section: Discussionmentioning

confidence: 99%

Sarcoid reaction: a rare occurrence associated to colon adenocarcinoma (case report and literature review)

Arco¹,

Fernández-Aceñero²

2016

J. Gastrointest. Oncol.

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Granulomatous reactions are related to infectious and non infectious diseases, but more rarely, granulomas may occur in association to malignancies. The presence of sarcoid-like granulomas in lymph nodes draining malignant tumors is an uncommon but well known occurrence. However, their presence in the stroma of malignant tumors is much rarer. We have only found two previous cases reported in the Japanese and English literature. In this study we report a well differentiated adenocarcinoma of the right colon associated to a stromal granulomatous sarcoid-like reaction. Lymph nodes were not involved. The patient had a clinical history of tuberculosis treated 15 years ago, but there was no clinical, histomorphological, immunohistochemical or molecular evidence of disease at the moment of these findings.We have reviewed the literature to find the keys and the diagnostic challenges posed by granulomatous sarcoid-like reaction occurring in lymph nodes draining malignant neoplasms, peritumoral stroma and in other organs far from the primary tumor. The diagnosis of granulomatous sarcoid-like reactions associated to malignancies can be challenging and it can only be made after ruling out specific infectious and non infectious causes of granulomatous inflammation. The mechanisms involved in granuloma formation, their relationship with demographic and histopathological features, their possible association with autoimmune disorders, their cytokine profile and, more importantly, their prognostic significance in each type of tumor are still unclear and require studies with larger number of patients. J Gastrointest Oncol 2016;7(4):E72-E76 jgo.amegroups.com of pulmonary tuberculosis treated for 9 months 15 years before. Computed tomography (CT) revealed a mass in the right colon and he underwent colonoscopy. Colonoscopy revealed an excrescent mass in the cecum and ileocecal valve with partial stenosis of the lumen. Biopsies showed a well differentiated adenocarcinoma. A right hemicolectomy was subsequently performed. Postoperative course was complicated by fever due to a possible dehiscence of the anastomosis with air bubbles near the ileal loop, but the patient evolved well and was finally discharged and is currently being followed in the surgery outpatient clinics.The surgical specimen consisted of ileum, caecum and right colon measuring 26 cm in length. In the ascending colon there was an excrescent lesion with well defined high borders and a central concavity. It was circumferential and obliterated 90% of the colonic lumen. It measured 7 cm × 4.5 cm and infiltrated through the wall into the adjacent fat.Microscopic examination confirms an infiltrating moderately differentiated colonic carcinoma extending into the subserosal fat. It shows an infiltrative leading edge without budding or desmoplasia and a moderate intratumoral and peritumor lymphocytic response. Metastases were found in 1 of 36 lymph nodes examined. Immunohistochemistry for mismatch repair proteins showed intact nuclear positivity. There was a granulom...

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“…Therefore, it has been suggested to include tumors in the list of differential diagnosis of granulomatous inflammation of unknown origin (12,13).…”

Section: Discussionmentioning

confidence: 99%

Sarcoid reaction: a rare occurrence associated to colon adenocarcinoma (case report and literature review)

Arco¹,

Fernández-Aceñero²

2016

J. Gastrointest. Oncol.

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Macrophage-derived FGFR1 drives atherosclerosis through PLCγ-mediated activation of NF-κB inflammatory signalling pathway

Wang,

Luo,

Zhang

et al. 2024

Cardiovascular Research

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Background Atherosclerosis is a leading cause of cardiovascular morbidity and mortality. Atherosclerotic lesions show increased levels of proteins associated with the fibroblast growth factor receptor (FGFR) pathway. However, the functional significance and mechanisms governed by FGFR signaling in atherosclerosis are not known. In the present study, we investigated FGFR1 signaling in atherosclerosis development and progression. Methods and Results Examination of human atherosclerotic lesions and aortas of Apoe-/- mice fed a high-fat diet (HFD) showed increased levels of FGFR1 in macrophages. We deleted myeloid-expressed Fgfr1 in Apoe-/- mice and showed that Fgfr1 deficiency reduces atherosclerotic lesions and lipid accumulations in both male and female mice upon HFD feeding. These protective effects of myeloid Fgfr1 deficiency were also observed when mice with intact FGFR1 were treated with FGFR inhibitor AZD4547. To understand the mechanistic basis of this protection, we harvested macrophages from mice and show that FGFR1 is required for macrophage inflammatory responses and uptake of oxidized LDL. RNA sequencing showed that FGFR1 activity is mediated through phospholipase-C-gamma (PLCγ) and the activation of nuclear factor-κB (NF-κB) but is independent of FGFR substrate 2. Conclusion Our study provides evidence of a new FGFR1-PLCγ- NF-κB axis in macrophages in inflammatory atherosclerosis, supporting FGFR1 as a potentially therapeutic target for atherosclerosis-related diseases.

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A sarcoidosis‐like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with FGFR1 gene amplification

Cited by 2 publications

References 12 publications

Sarcoid reaction: a rare occurrence associated to colon adenocarcinoma (case report and literature review)

Sarcoid reaction: a rare occurrence associated to colon adenocarcinoma (case report and literature review)

Macrophage-derived FGFR1 drives atherosclerosis through PLCγ-mediated activation of NF-κB inflammatory signalling pathway

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