A rare case of paragonimiasis miyazakii with lung involvement diagnosed 7 years after infection: A case report and literature review

Yatera, Kazuhiro; Hanaka, Minako; Hanaka, Tetsuya; Yamasaki, Kei; Nishida, Chinatsu; Kawanami, Toshinori; Kawanami, Yukiko; Ishimoto, Hiroshi; Kanazawa, Tamotsu; Mukae, Hiroshi

doi:10.1016/j.parint.2015.02.009

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…The diagnosis of paragonimiasis could be challenging due to variable and non-specific presentations. The most frequent symptoms of this group are gastrointestinal symptoms, which is consistent with previous studies (Yatera et al, 2015;Nagayasu et al, 2015;Gong et al, 2017), and this possibly could be explained by the penetration of the small intestine after infection (Procop, 2009). Other symptoms, such as syncope, dyspnea, fatigue, edema and palpitation, are mainly due to the PE and obstruction of venous blood inflow.…”

Section: Commentsupporting

confidence: 88%

Diagnosis and surgical management of pericardial effusion due to paragonimiasis

Zhou

Jin

et al. 2019

International Journal of Infectious Diseases

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Objectives: The pericardial effusion (PE) caused by paragonimiasis is rarely reported. This study aims to present experience in the diagnosis and surgical management of PE due to paragonimiasis. Methods: Medical records of 57 children who were diagnosed with PE due to paragonimiasis and underwent surgery at Children's Hospital of Chongqing Medical University between January 2012 and August 2018 were retrospectively reviewed. Results: The average age of this group was 7.6 AE 3.0 years. Patients were mainly from Chongqing and Sichuan areas. ELISA for Paragonimus skrjabini in all 57 patients showed positive results. Moderate or large PE were identified in 12 and 45 patients, respectively. All patients underwent surgery either by pericardectomy or thoracoscopic surgery. Pathological exams indicated massive eosinophil infiltration in all 57 specimens. After 3-4 courses of praziquantel therapy, the clinical outcomes were satisfactory. Conclusions: Typical endemic history, eosinophilia and multiple serous effusion raise suspicions of paragonimiasis. Once moderate to large PE is identified in patients with paragonimiasis, surgical treatment is necessary.

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Section: Commentsupporting

confidence: 88%

Diagnosis and surgical management of pericardial effusion due to paragonimiasis

Zhou

Jin

et al. 2019

International Journal of Infectious Diseases

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“…Similar results were reported by previous studies. [ 13 , 21 ] Respiratory symptoms of can be easily confused with those of TB. [ 12 , 24 ] Additionally, Barennes et al [ 25 ] reported that 3 (2.5%) of 118 patients with negative acid-fast bacilli smear who were suspected to have pulmonary TB were diagnosed with paragonimiasis.…”

Section: Discussionmentioning

confidence: 99%

Paragonimiasis in Children in Southwest China

et al. 2017

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Background:Paragonimiasis infection has no specific symptoms or typical radiologic findings, leading to the possibility of misdiagnosis. Thus, the objective of this study was to analyze clinical and radiological features, and treatment outcome of paragonimiasis in children in Southwest China to improve the awareness of this disease.Methods:We retrospectively reviewed the records of children diagnosed with paragonimiasis in West China Second University Hospital between 2005 and 2016. The confirmed diagnosis of paragonimiasis was based on epidemiology history and seropositivity for paragonimiasis and/or detection of paragonimus eggs. Clinical, laboratory, and imaging findings of patients were examined in order to summarize risk factors, clinical characteristics, and treatment outcomes of these patients.Results:A total of 123 patients were included; of them 112 (91.1%) lived in villages and 72 (58.5%) had a history of consuming freshwater crabs. Patients with paragonimiasis most frequently showed respiratory symptoms, including cough (26.0%, 32/123) and tachypnea (16.3%, 20/123), and gastrointestinal symptoms, including abdominal pain (26.8%, 33/123), abdominal distention (22.8%, 28/123), and vomiting (13.0%, 16/123). Laboratory examination showed elevated white blood cell (WBC) counts in the peripheral blood in 89 (72.4%) patients and eosinophilia in 102 (82.9%) patients. Tuberculosis (TB) coinfection was found in 4 (3.3%) patients. Main imaging findings included: effusions (90.4%), lymphadenopathy (40.4%), pulmonary ground-glass opacities (36.2%), cystic lesions (18.1%), and pleural thickening (17.0%). Twenty-nine patients (23.6%) received more than 1 course of praziquantel (PZQ). Additionally, 4 (19.0%) of 21 patients who were discharged from the hospital without complete treatment required rehospitalization for residual serous effusions. Moreover, patients from pericardial effusion group showed longer hospital stays and less elevated WBC counts than those from nonpericardial effusion group.Conclusion:Paragonimiasis should be considered in patients from endemic areas, especially in those with gastrointestinal and/or respiratory symptoms, elevated WBC count, eosinophilia, and serous effusions. Additionally, longer hospital stay may be necessary in cases of paragonimiasis associated with pericardial effusions.

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“…In 11 patients with cerebral paragonimiasis multiple courses of praziquantel (3 × 25 mg/kg/d for 3 days) did not result in improvementl [33] . These patients were cured after an additional treatment with 10 mg/kg triclabendazole.…”

Section: Discussionmentioning

confidence: 89%

“…Two case reports merit to be discussed in detail. Qian et al reported that in some patients with paragonimiasis in the brain multiple courses of praziquantel (3 × 25 mg/kg/d for 3 days) did not result in improvement [33] . These patients were cured after an additional treatment with 10 mg/kg triclabendazole.…”

Section: Resultsmentioning

confidence: 99%

Current status of the treatment of paragonimiasis

Richter¹

2022

One Health Implement Res

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Paragonimiasis, a foodborne trematodiasis is caused by various Paragonimus species endemic in Asia, Africa, and the Americas. Human infection occurs through consuming improperly cooked freshwater crustaceans, crabs or crayfish, eating raw meat of paratenic hosts or by ingesting metacercariae from contaminated hands and cooking utensils. More than 292 million persons worldwide are at risk. The morbidity associated with paragonimiasis includes acute febrile illness and chronic pleuro-pulmonary manifestations which may be confounded with tuberculosis or lung cancer. Ectopic manifestations mostly involve the central nervous system, heart, or subcutaneous tissues. Objectives: to evaluate the efficacy and safety of currently available drugs praziquantel (PZQ) and triclabendazole (TCZ). Methods: a PubMed and Google Scholar search and reference selection was performed according to the the Preferred Reporting Items for Systematic Reviews protocol using a combination of the terms “paragonimiasis” AND “treatment” OR “therap*” from 01/2000 to 02/2022. Results: no randomized controlled trials were identified. Five open trials on 487 patients treated with PZQ showed 81%-100% parasite clearance depending on dosage and duration. Three open trials on 226 patients with TCZ showed a 99.6% efficacy. A quantitative comparison was not applicable to retrospective analyses of hospital records, case series and case reports because of surgical interventions, various co-morbidities and -medications and definitions of cure. Some patients treated with PZQ required multiple courses or re-treatment with TCZ, whereas one patient treated with TCZ required re-treatment with PZQ. Conclusions: PZQ and TCZ are usually effective for treating paragonimiasis. Controlled randomized trials are required to compare the safety, efficacy and applicability of PZQ versus TCZ and to evaluate combined PZQ-TCZ therapy.

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A rare case of paragonimiasis miyazakii with lung involvement diagnosed 7 years after infection: A case report and literature review

Cited by 13 publications

References 8 publications

Diagnosis and surgical management of pericardial effusion due to paragonimiasis

Diagnosis and surgical management of pericardial effusion due to paragonimiasis

Paragonimiasis in Children in Southwest China

Current status of the treatment of paragonimiasis

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