A Rare Case of Pancreatic Endometrial Cyst and Review of the Literature

Yamamoto, Ryōichi; Konagaya, Kensuke; Iijima, Hironobu; Kashiwagi, Hirokazu; Hashimoto, Masanori; Shindo, Asumi; Sasaki, Yuki; Yamamoto, Kota; Nakagawa, Masashi; Suno, Yuma; Abe, Toshiyuki; Takaki, Mutsuo; Suda, Koichi; Watanabe, Kazuomi

doi:10.2169/internalmedicine.1702-18

Cited by 11 publications

(8 citation statements)

References 13 publications

(12 reference statements)

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“…There are several theories suggesting the pathophysiology of endometriosis and include the direct endometrial tissue extension unto neighboring organs, retrograde menstruation, ectopic production of endometrial stoma from embryonic vestiges, bone marrow and stem cells as well as hematogenous or lymphatic spread. 6,7 …”

Section: Discussionmentioning

confidence: 99%

Pancreatic endometrioma : a rare differential diagnosis for a pseudocyst

Alnuaimi¹,

Akmal

Alduaij

et al. 2023

BJR|case reports

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Pancreatic endometriosis is extremely rare with only 14 cases reported in the medical literature and its diagnosis on radiological imaging poses a great challenge. We report a case of a 31 year old female patient with recurrent admissions for pancreatitis of unknown aetiology and no relevant past medical history. Sectional imaging showed a cystic lesion in the tail of the pancreas and the diagnosis of a post-pancreatitis pseudocyst or a less likely pre-malignant mucinous cystadenoma was considered. On post-robotic resection of the pancreatic cyst the histopathology analysis was positive for endometrial stroma. Pancreatic endometriosis although rare should be considered as a differential diagnosis for cystic lesions especially in patients who are known to have pelvic endometriosis. Nevertheless, the gold standard for the definite diagnosis of pancreatic endometriosis remains histopathological.

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Section: Discussionmentioning

confidence: 99%

Pancreatic endometrioma : a rare differential diagnosis for a pseudocyst

Alnuaimi¹,

Akmal

Alduaij

et al. 2023

BJR|case reports

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“…12 Other reports indicate an association between atypical sites of endometriosis, including in the pancreas, which may lead to abdominal pain that can occur at the onset of menses; however, in these cases, cystic lesions of the pancreas or other laboratory abnormalities including an elevated white blood cell count and C-reactive protein have been reported. [15][16][17] Ectopic endometriosis was not assessed in the 2 patients presented here.…”

Section: Discussionmentioning

confidence: 99%

Menstruation-Associated Acute Pancreatitis in Patients with Hereditary Pancreatitis

Khalaf

Narkewicz

El-Haija

2021

The Journal of Pediatrics

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Two adolescent girls presented with recurrent episodes of menstrual cycle-associated acute pancreatitis and are diagnosed with hereditary pancreatitis, a cause of chronic pancreatitis. Hereditary pancreatitis should remain in the differential diagnosis for teenage girls with catamenial acute pancreatitis and family history of pancreatic disease.Hereditary pancreatitis is one of the risk factors that leads to chronic pancreatitis and is characterized by early onset of disease, typically in childhood. Several genes have been associated with chronic pancreatitis including PRSS1 (gene-encoding cationic trypsinogen), SPINK1 (serine protease inhibitor, Kazal type 1), CFTR (cystic fibrosis), CPA1 (carboxypeptidase A1), and CTRC (chymotrypsin C) genes, and other genes. [1][2][3][4][5][6][7] Hereditary pancreatitis classically has been described secondary to PRSS1 genetic defects, most commonly a pathogenic R122H mutation (c.365G>A), has a variable spectrum of severity and presentation, and is clinically indistinguishable from other forms of acute pancreatitis and chronic pancreatitis. 8 In a multinational cohort of 301 children with acute recurrent pancreatitis and chronic pancreatitis, 17% of individuals with acute recurrent pancreatitis and 46% of children with chronic pancreatitis had a pathogenic PRSS1 mutation. 9 Approximately one-half of the patients with pathogenic PRSS1 mutations progress to chronic pancreatitis by 20 years of age. 8,10 Few triggers are known to be associated with episodes of acute pancreatitis in patients with pathogenic PRSS1 mutations, including alcohol consumption. One case report has previously shown onset of a menstrual cycle triggering episodes of acute pancreatitis in a teenage girl with Hereditary pancreatitis secondary to a pathogenic R122H mutation was reported. 11 A diagnosis of acute pancreatitis can be made according to subspecialty

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“…On the contrary, IPMN pseudocysts are in communication with the branches of the pancreatic duct, affecting women between 40 and 50 years of age. They appear as complex masses, partly solid, partly cystic, affect women of childbearing age and are often characterized by arterial enhancing and calcifications [157]. When the imaging findings are not specific (as in most cases), surgical findings are indicated; on histological examination, pancreatic endometriotic lesions always reveal the presence of endometrial glands and stroma, associated with hemorrhages and macrophages filled with hemosiderin [158].…”

Section: Pancreatic Endometriosismentioning

confidence: 99%

“…If, on the other hand, ovarian suppression therapy does not produce benefits, surgical excisional therapy of the lesions found is a priority (Table 5, Ref. [152,[154][155][156][157][158][159][160][161][162]).…”

Section: Pancreatic Endometriosismentioning

confidence: 99%

Rare extragenital endometriosis: pathogenesis and therapy

Fedele¹,

Fatta²,

Busnelli³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: In the context of extragenital endometriosis, the gastrointestinal, urinary tract, abdominal wall, and thorax localizations are considered relatively frequent, while the umbilical, inguinal, sciatic nerve, liver, and pancreas are instead "rare". Methods: Online searches were carried out in PubMed database of the last 20 years for these terms: extragenital endometriosis, umbilical endometriosis, inguinal endometriosis, sciatic nerve endometriosis, hepatic and pancreatic endometriosis. The following exclusion criteria were used:(1) Personal surgical history unspecified. (2) Nonspecific histological diagnosis for each type of endometriosis examined. (3) Inability to distinguish between the personal series of the author and the case reports described. (4) Proceedings of scientific meetings were not included. Tables that are easy to consult were compiled. Results: 810 titles were found among which 162 studies were selected for reading in full text and finally 114 papers were included, which met the objective of the revision. The so-called "rare" forms of extragenital endometriosis show an unsuspected frequency, an extreme variability of presentation, and uncertain treatment guidelines. Discussion: Gynecologists, general surgeons, and neurologists should be well acquainted with these pathologies to avoid confusing diagnostic paths and to set up adequate therapies.

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A Rare Case of Pancreatic Endometrial Cyst and Review of the Literature

Cited by 11 publications

References 13 publications

Pancreatic endometrioma : a rare differential diagnosis for a pseudocyst

Pancreatic endometrioma : a rare differential diagnosis for a pseudocyst

Menstruation-Associated Acute Pancreatitis in Patients with Hereditary Pancreatitis

Rare extragenital endometriosis: pathogenesis and therapy

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