A rare case of multiple carcinoids and endocrine cell micronests in a patient with chronic duodenitis

Neuroendocrine tumours of the duodenum

“…All tumours in our patients but one were solitary. To the authors' knowledge, until now only one patient with multiple duodenal NTs in the absence of MEN type I, ZES or gastritis type A has been reported [27]. The patient presented in this study showed, in contrast to our patient with multiple NTs (no.…”

A Case of Fifteen Simultaneous Rectal Neuroendocrine Tumors and Endocrine Cell Micronests Resected by Both Endoscopic Treatments and Surgery

“…It has not been confirmed that ECM is a malignant lesion (pre-NET lesion) [ 4 , 8 ]. In the current report, 2 cases with ≥4 lesions had ECM (Table 1 ), and there was no LNM.…”

“…Multiple rectal NETs are sometimes reported, but their characteristics, including LNM, remain unclear [ 3 ]. NETs rarely include endocrine cell micronests (ECMs), which are reported as clusters of endocrine cells of <0.5 mm in size, and the details of ECMs are also unclear [ 4 ]. In this case report, we presented the case of a patient with 15 rectal NETs and ECMs.…”

Molecular Biology and Pathology of Paediatric Cancer

“…The smaller ECMPs and transitional lesions did not exhibit expansile growth or intervening fibrous stroma. Abe et al, 3 in describing a case of multiple duodenal endocrine cell proliferations, defined carcinoid tumours as greater than 3 mm diameter, microcarcinoids as between 0.5 and 2.9 mm, and lesions smaller than 0.5 mm (which they interpreted as hyperplastic) as ''endocrine cell micronests''. According to these criteria, most of the lesions in our case would be classified as ECMPs or micronests.…”

“…1 In contrast to Crohn's disease, in multiple sclerosis (MS), the chronic inflammation in the central nervous system is commonly assumed not to be linked to bacterial infections, but rather is driven by autoreactive T cells that recognise self antigens. 3 Frozen tissue sections from two normal colons, two normal ileums, colon specimens from two patients with Crohn's disease, two lesions from one patient with MS (case 2 in Babbe and colleagues 4 ), and three normal brains, were stained with the following monoclonal antibodies: anti-CD14-biotin (BMA Biomedicals, Augst, Switzerland), anti-SLAM (Kamiya Biomedical, Seattle, Washington, USA), and anti-CD68 (Dako, Hamburg, Germany).…”