A rare case of Krukenberg tumor by gallbladder cancer

Pesce, Antonio; Destri, Giovanni Li; Amore, Francesca Flavia; Magro, Gaetano; G, La Greca; Puleo, Stefano

doi:10.1016/j.amsu.2019.09.014

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Additionally, histological assessment is crucial, and a multidisciplinary approach is necessary to prevent certain mistakes. Indeed, the occurrence of the Krukenberg tumor should be considered in the workup of gallbladder cancer by keeping in mind this rare occurrence in clinical practice [10]. As per the study by An-Chieh Liu et al, the original lesion of a Krukenberg tumor is too tiny to be seen.…”

Section: Discussionmentioning

confidence: 98%

Krukenberg Tumour in a 34-Year-Old Female: A Case Report

Chavhan,

Gedekar,

Vagga

et al. 2024

Cureus

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A metastatic condition involving signet ring cells rich in mucin is the Krukenberg tumor, which affects the ovaries. Usually, the metastatic disease does not include both ovaries and usually originates from the stomach side, while it can also occur less frequently from other locations. Krukenberg tumors are uncommon in younger age groups and usually occur after the age of 40. We report a case of a 34-year-old female patient with a primary form of past medical history. The patient was treated with multiple rounds of chemotherapy.

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Section: Discussionmentioning

confidence: 98%

Krukenberg Tumour in a 34-Year-Old Female: A Case Report

Chavhan,

Gedekar,

Vagga

et al. 2024

Cureus

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“…Метастатичні карциноми яєчника, за даними різних досліджень, становлять майже 15 % від усіх злоякісних новоутворень яєчників (показники варіюють від 3 % до 30 %). Найпоширеніше первинне джерелоколоректальна карцинома (32,0 %), карцинома молочної залози (15,4 %), карцинома ендометрія (12,9 %), карцинома шлунка (9,2 %), карцинома апендикса (6,7 %), рак шийки матки (2,4 %), рак підшлункової залози (2,2 %), рак тонкої кишки (1,6 %), рак жовчного міхура та жовчних шляхів (1,5 %) [6,7,8,9]. Інші пухлини, як-от карцинома легенів, пухлини шкіри, рак нирки та карцинома стравоходу, становлять менше ніж 1 % кожна [10,11].…”

Section: Discussionunclassified

Differential diagnosis of primary and metastatic ovarian carcinomas

Zakhartseva,

Manzhura,

Vashchenko

et al. 2023

Pathologia

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Ovarian tumors constitute 3.4 % of the structure of oncological diseases in women worldwide. However, the ovaries are also a common target for metastasis of carcinoma from other organs. Conducting differential diagnosis between primary carcinoma and metastasis is often challenging. The aim of this study is to highlight the issues of morphological and immunohistochemical differential diagnosis of primary ovarian carcinomas and metastases from carcinomas of various organs to the ovaries. Materials and methods. Data analysis of clinical and pathohistological studies of 381 patients. Paraffin sections for pathohistological studies were stained with hematoxylin and eosin using standard methodology. Immunohistochemical studies were conducted in 161 cases using a panel of antibodies: cytokeratins, estrogen receptors, progesterone receptors, CA125, TTF1, Vimentin, CDX2, Villin, Chromogranin A, Synaptophysin, CD56, GATA, p53, Inhibin A, FOXL-2, PAX-8, Ki-67. The specimens were examined and analyzed using the Axioskop 40 microscope (Zeiss) with the AxioCam MRc camera (Zeiss). Results. The article discusses key issues of differential diagnosis of primary and metastatic ovarian carcinomas based on a large clinical and operational material. The application of an adequate panel of immunohistochemical antibodies for verification is considered. The results of the frequency of occurrence of different histological variants of ovarian carcinomas and metastases to the ovaries from carcinomas of other organs are provided based on our own research from 2019 to 2023. The main morphological and immunohistochemical indicators for practical use in the work of a pathologist in the verification of ovarian tumors are presented. An example of forming an antibody panel, taking into account clinical and morphological indicators in a specific clinical case from our own practice, is given. Conclusions. Metastases of carcinomas from other organs to the ovaries constitute half of all cases requiring immunohistochemical investigation based on morphological structure. The most common are metastases from breast and colorectal cancers. However, the diagnosis of metastatic intestinal carcinoma is particularly challenging, as there is usually no clear clinical picture. In the differential diagnosis of primary and metastatic ovarian tumors, a comprehensive approach to analyzing the clinical presentation, microscopic structure of the tumor, and the surrounding tissue plays a significant role. Additionally, the formation of an antibody panel, taking into account these data, is crucial. The article provides a list of antibodies that have demonstrated greater effectiveness in our work.

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“…There are few case reports of gallbladder carcinoma with metastasis to ovaries which has been inadvertently diagnosed as primary ovarian carcinoma preoperatively. 3 Carcinoma of the gallbladder is an incidental finding in 1% of patients undergoing cholecystectomy because of presenting cholelithiasis. Most gallbladder cancers are adenocarcinoma (incidence 70-90%).…”

Section: Discussionmentioning

confidence: 99%