A rare case of intrarenal teratoma in a 6-month-old male

Evans, Kathryn; Rogers, Timothy; Garrett-Cox, Robin

doi:10.1002/pbc.22621

Cited by 3 publications

(3 citation statements)

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“…So far, only 3 articles have reported renal immature teratoma, and all of them occur in infant or children. [4,8,9] The clinical characteristics and pathologic features of these renal immature teratoma were shown in Table 1. To the best of our knowledge, our patient is the first known case with renal immature teratoma in adult.…”

Section: Discussionmentioning

confidence: 99%

Renal immature teratoma in a male adult

Zhang

Xu²,

Li³

et al. 2018

Medicine

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Section: Discussionmentioning

confidence: 99%

Renal immature teratoma in a male adult

Zhang

Xu²,

Li³

et al. 2018

Medicine

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“…5 In cases of recurrent disease, a combination of surgical resection followed by chemotherapy recommended. 5 …”

Section: Discussionmentioning

confidence: 99%

“…Only 16 cases of intrarenal teratoma in children have been reported5 and only few of them reported as immature. [5][6][7] The main primary childhood renal neoplasms are nephroblastoma, mesoblastic nephroma, clear cell sarcoma and rhabdoid tumor. The teratoid nephroblastoma can be confused with a teratoma because of the presence of heterologus tissues.…”

Section: Introductionmentioning

confidence: 99%

Immature teratoma of kidney in a 5-month-old child

Adhikari

Sayami

2013

J Pathol Nep

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We report a rare case of immature renal teratoma in a 5-month-old female infant. The patient presented with abdominal mass, which was found to arise from the left kidney. The preoperative diagnosis of Wilms' tumor was based on clinical and imaging fi ndings. The patient was managed with nephrectomy and had normal recovery. The histopathological examination of nephrectomy specimen revealed grade 2 immature teratoma.

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“Teratoid” Wilms Tumor

D’Hooghe

Mifsud

Vujanić

2019

American Journal of Surgical Pathology

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Wilms tumor (WT) may show a diverse range of heterologous elements (HEs). Cases with predominant/prominent HEs have been reported as “teratoid” WT, albeit on the basis of poorly defined criteria. It has been suggested that “teratoid” WTs are rare, and associated with a poor response to chemotherapy, but a good outcome. However, these claims have not been tested previously in any large cohort of cases. Here, we performed a systematic study to determine the incidence, diversity, and clinicopathologic association of HEs in 691 WTs, all of which were treated according to the same protocol, which included preoperative chemotherapy, and all with central pathology review. We found that 4% (28/691) of WTs showed ≥3 HEs (“teratoid” WT in our study), which was comparable to the numbers of completely necrotic, epithelial, focal anaplastic, and blastemal WTs. “Teratoid” WTs were strongly associated with younger age at presentation (21 vs. 39 mo, P=0.0001), bilateral disease (28.6% vs. 7.2%, P=0.001), stromal-type WT (57.1% vs. 11.0%, P<0.00001), and intralobar nephrogenic rests (35.7% vs. 11.9%, P=0.0001), when compared with non-“teratoid” WT. We also found that stromal-type WT, regardless of HE differentiation, was itself associated with younger age, bilateral disease, and intralobar nephrogenic rest. Furthermore, >80% of cases with ≥3 HEs, and also of cases with 2 HEs and 1 HE, showed ≥50% stroma in their viable components. We conclude that a tendency toward stromal differentiation is a strong and unifying factor in HE formation. “Teratoid” WT represents the more extreme end of HE differentiation, rather than a separate entity, and therefore the term should not be used in the final diagnosis. The prognosis of WTs depends only on their overall histologic type and stage, and it is not additionally influenced by the presence of “teratoid” features.

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A rare case of intrarenal teratoma in a 6-month-old male

Cited by 3 publications

References 13 publications

Renal immature teratoma in a male adult

Renal immature teratoma in a male adult

Immature teratoma of kidney in a 5-month-old child

“Teratoid” Wilms Tumor

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