A Rare Case of Intraoral Nodular Fasciitis: Diagnosis And Immunohistochemical Profile

Lima, Francisco Jadson; Lopes, Maria Luiza Diniz de Sousa; Costa, Maycon Douglas De Olveira; Silva, Raissa Harris Gomes Lopes Da; Nóbrega, Fernando José de; Freitas, Roseana de Almeida; Silveira, Éricka Janine Dantas da

doi:10.1016/j.oooo.2013.11.009

Cited by 5 publications

(8 citation statements)

References 8 publications

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“…Rhabdomyosarcoma is positive for myogenin (a nuclear stain), which is a highly specific stain for this tumour. NF is S100‐negative, therefore ruling out melanocytic and neural tumours, including neurofibromas . Dermatofibrosarcoma protuberans is CD34‐positive and Factor XIIIa‐negative, in contrast to NF, which is CD34‐negative and can have focal areas of Factor XIIIa positivity …”

Section: Reportmentioning

confidence: 99%

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Nodular fasciitis of the lip mucosa: a rare but clinically important entity

2015

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Oral nodular fasciitis (NF) is a rare benign entity of significant clinical importance, which presents as a rapidly growing soft tissue mass. Awareness of this entity is essential, because histologically it resembles a malignancy at first glance, owing to its spindled histological nature and numerous typical mitoses. Thus, it is often misdiagnosed as an aggressive sarcoma, resulting in unnecessary radical surgery. In total, 45 cases of oral NF have been reported since 1966, of which only 2 were reported in the dermatological literature. Patients with NF of the lip mucosa will frequently present to a dermatologist. Therefore, it is critical that dermatologists recognize this benign neoplasm to correctly manage it and avoid potentially catastrophic unnecessary surgery, as these lesions typically spontaneously resolve. We describe the clinical, histological and immunohistochemistry findings of NF in a 51-year-old woman, and discuss its differential diagnosis.

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Section: Reportmentioning

confidence: 99%

“…Most commonly it is located on the upper extremities and trunk. Only 45 cases of oral NF have been reported between 1966 and 2013, of which only 1 was present on the lower lip mucosa . NF does not commonly occur in the oral cavity because it is thought to arise from fascia, which is not prominent in this area …”

mentioning

confidence: 99%

Nodular fasciitis of the lip mucosa: a rare but clinically important entity

2015

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“…Previously nodular fasciitis was thought to be reactive in nature. Infection and hormonal influences have also been suggested as initiating factors [2,17,18]. However, genetic research proves that nodular fasciitis undergoes a clonal expansion process [8].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Nodular Fasciitis on the Front Surface of the Neck

Pogosyan¹,

Hakobyan²,

Hovhannisyan³

et al. 2020

DOBCR

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Nodular fasciitis (NF) is a benign reactive or inflammatory condition of mesenchymal fibroblasts. Rapid growth and histological features make nodular fasciitis a mimicker of malignancies such as sarcomas, however, nodular fasciitis is a benign lesion and does not metastasize. Although the etiology of nodular fasciitis is uncertain, histopathologically, it bears a close resemblance to organizing granulation tissue, and myofibroblastic proliferation may be initiated by a local injury or local inflammatory process, which supports a reactive proliferation theory triggered by trauma. Surgical excision is recommended for diagnosis and treatment to exclude malignancy. We are hereby reporting a case of nodular fasciitis on the front surface of the neck, 86 years old patient. Tumor grew rapidly and reached 9-10 cm., and which was clinically suspected as a malignancy located. An ultrasound examination was performed. Based on the clinical and ultrasound data, it was decided to perform an extended biopsy to establish the final diagnosis it. Tumor has been removed as a solid mass. The material was sent for histopathological examination. Based on the history, clinical picture, and histopathological examination, the lesion was diagnosed as nodular fasciitis. After surgery patient expressed satisfaction with the result of treatment. In cases of nodular fasciitis, proactive efforts are needed to perform histopathologic evaluation and treatment because nodular fasciitis tends to grow rapidly.

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“…The lesions are usually immunonegative for keratin, S-100 protein and desmin. Histomorphologic features aided by an appropriate immunohistochemical profile are thus useful in the accurate diagnosis of nodular fasciitis [8].…”

Section: Discussionmentioning

confidence: 99%

Nodular Fasciitis of the Orofacial Region: An Uncommon Differential

Deen

Majhi

2015

J. Maxillofac. Oral Surg.

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Nodular fasciitis is a benign proliferative spindle-cell lesion that presents as a rapidly growing mass arising from the subcutaneous fascia, leading it to be erroneously diagnosed as a sarcoma. These lesions commonly present in individuals in their third to fifth decades of life with no definite gender predilection. They are frequently located on the extremities and the trunk and infrequently in the head and neck region. Lesions in the orofacial region are uncommon. We describe an interesting case of orofacial nodular fasciitis in a 21-year-old boy that essentially summarises the clinical features and management of this pseudosarcomatous reactive proliferative lesion. Clinicians and more so maxillofacial surgeons need to be aware of the distinctions between nodular fasciitis and its malignant mimic (sarcomas) in order to limit overtreatment and the resultant treatment-related morbidities.

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A Rare Case of Intraoral Nodular Fasciitis: Diagnosis And Immunohistochemical Profile

Cited by 5 publications

References 8 publications

Nodular fasciitis of the lip mucosa: a rare but clinically important entity

Nodular fasciitis of the lip mucosa: a rare but clinically important entity

Treatment of Nodular Fasciitis on the Front Surface of the Neck

Nodular Fasciitis of the Orofacial Region: An Uncommon Differential

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