Nodular fasciitis of the lip mucosa: a rare but clinically important entity

Lloyd, Amanda Abramson; Witheiler, Daniel; Menter, Alan

doi:10.1111/ced.12564

Cited by 13 publications

(12 citation statements)

References 18 publications

(83 reference statements)

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“…In this case, the spindle-shaped myofibroblast-like cells stained positive for smooth muscle actin. This was also observed in the cases that were reported by lloyd et al, Ikebe et al and Souza et al [4,17,18] however, NF has to be distinguished from other benign tumors of myofibroblastic origin. Inflammatory myofibroblastic tumor (IMT) is generally larger than NF, tends to occur at a younger age, and is composed of longer fascicles of spindle cells in an inflammatory background that is rich in plasma cells.…”

Section: Commentarysupporting

confidence: 57%

“…NF most commonly present in the extremities, trunk, head and neck region. The incidence of NF in the oral cavity is very rare and it occurs mostly in the buccal mucosa, alveolar mucosa, tongue and upper lip [2][3][4]. Nodular fasciitis occurs equally among both males and females in the fourth and fifth decades of life.…”

Section: Introductionmentioning

confidence: 99%

“…Although NF is a benign reactive lesion, due to its rapid growth, high cellularity and high mitotic rate it is often misdiagnosed as a sarcoma [7]. NF has to be differentiated from schwannoma, myofibroma, solitary fibrous tumor, fibrosarcoma, leiomyosarcoma, neurofibroma and malignant fibrous histiocytoma [4,6,8]. The positivity of tumor cells for smooth muscle actin (a-SMA), muscle specific actin (HHF-35) and vimentin has established the myofibroblastic origin of NF [9].…”

Section: Introductionmentioning

confidence: 99%

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Oral nodular fasciitis – A case report with a diagnostic schema

Rathna

Mathew

Kudva

et al. 2019

J Oral Med Oral Surg

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Introduction: The spectrum of myofibroblastic lesions of the oral cavity ranges from reactive to benign to malignant lesions with overlapping histopathologic and immunohistologic characteristics posing a diagnostic dilemma. Observation: A 30-year-old male presented with a spontaneous swelling over the right lower buccal gingiva giving a clinical suspicion of a benign mesenchymal tumor. The lesion presented with a varied biphasic microscopic appearance that posed as a challenge for diagnosis. Commentaries: The incisional biopsy of the lesion showed a highly collagenous stroma with spindle-shaped cells, while the excision biopsy revealed myxoid and hyalinized stroma. A panel of markers comprising of SMA (smooth muscle actin). CD-34, β-Catenin, and Alcian blue stain was employed to arrive at a diagnosis. Conclusion: Most myofibroblastic lesions present with diverse histological appearance which warrants a thorough assessment of the cellular and stromal components for an accurate diagnosis.

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Section: Commentarysupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oral nodular fasciitis – A case report with a diagnostic schema

Rathna

Mathew

Kudva

et al. 2019

J Oral Med Oral Surg

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“…These lesions may be confused with other more common benign soft tissue tumors such as fibroma, lipoma, desmoid tumor, chondroma, myxoma, schwannoma, atypical fibroxanthoma or rarely sarcomas [1]. Nodular fasciitis can at times be deceptively similar to a sarcoma by frequently extending along the fascial planes and exhibiting high cellularity, nuclear atypia and mitoses [6,7]. However, they have been shown to be distinctively benign with no potential for malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Nodular Fasciitis of the Orofacial Region: An Uncommon Differential

Deen

Majhi

2015

J. Maxillofac. Oral Surg.

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Nodular fasciitis is a benign proliferative spindle-cell lesion that presents as a rapidly growing mass arising from the subcutaneous fascia, leading it to be erroneously diagnosed as a sarcoma. These lesions commonly present in individuals in their third to fifth decades of life with no definite gender predilection. They are frequently located on the extremities and the trunk and infrequently in the head and neck region. Lesions in the orofacial region are uncommon. We describe an interesting case of orofacial nodular fasciitis in a 21-year-old boy that essentially summarises the clinical features and management of this pseudosarcomatous reactive proliferative lesion. Clinicians and more so maxillofacial surgeons need to be aware of the distinctions between nodular fasciitis and its malignant mimic (sarcomas) in order to limit overtreatment and the resultant treatment-related morbidities.

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“…Nodular fasciitis should be considered in the differential diagnosis of tumors for an accurate diagnosis and timely treatment. Nodular fasciitis has to be differentiated from schwannoma, myofibroma, solitary fibrous tumor, fibrosarcoma, leiomyosarcoma, neurofibroma and malignant fibrous histiocytoma [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Nodular Fasciitis on the Front Surface of the Neck

Pogosyan¹,

Hakobyan²,

Hovhannisyan³

et al. 2020

DOBCR

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Nodular fasciitis (NF) is a benign reactive or inflammatory condition of mesenchymal fibroblasts. Rapid growth and histological features make nodular fasciitis a mimicker of malignancies such as sarcomas, however, nodular fasciitis is a benign lesion and does not metastasize. Although the etiology of nodular fasciitis is uncertain, histopathologically, it bears a close resemblance to organizing granulation tissue, and myofibroblastic proliferation may be initiated by a local injury or local inflammatory process, which supports a reactive proliferation theory triggered by trauma. Surgical excision is recommended for diagnosis and treatment to exclude malignancy. We are hereby reporting a case of nodular fasciitis on the front surface of the neck, 86 years old patient. Tumor grew rapidly and reached 9-10 cm., and which was clinically suspected as a malignancy located. An ultrasound examination was performed. Based on the clinical and ultrasound data, it was decided to perform an extended biopsy to establish the final diagnosis it. Tumor has been removed as a solid mass. The material was sent for histopathological examination. Based on the history, clinical picture, and histopathological examination, the lesion was diagnosed as nodular fasciitis. After surgery patient expressed satisfaction with the result of treatment. In cases of nodular fasciitis, proactive efforts are needed to perform histopathologic evaluation and treatment because nodular fasciitis tends to grow rapidly.

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Nodular fasciitis of the lip mucosa: a rare but clinically important entity

Cited by 13 publications

References 18 publications

Oral nodular fasciitis – A case report with a diagnostic schema

Oral nodular fasciitis – A case report with a diagnostic schema

Nodular Fasciitis of the Orofacial Region: An Uncommon Differential

Treatment of Nodular Fasciitis on the Front Surface of the Neck

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