A rare case of hyperostosis frontalis interna in an 86-year-old Japanese female cadaver

Morita, Kazuma; Nagai, Akiko; Naitoh, Munetaka; Tagami, Ayako; Ikeda, Yayoi

doi:10.1007/s12565-020-00577-5

Cited by 3 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Now, with an increasing prevalence of the disease and more recent research on the topic, further discussion is warranted. Histological research has found cadaveric cases of HFI presenting with a layer of cortical bone along with typical spongy bone [ 2 ]. It is possible that HFI cases with layers of cortical bone will present with more significant increases in intracranial pressure and lead to more severe symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperostosis frontalis interna (HFI) is a rare phenomenon characterized by bony overgrowths involving the frontal bone and positioned bilaterally to the superior sagittal sinus [ 1 ]. Specifically, a new diploë layer forms deep to the internal table along with instances of mainly trabecular and lamellar bone [ 2 ]. Although the cause of HFI is currently not agreed upon among researchers, some leading theories involve hormone irregularities and changes in diet [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, a new diploë layer forms deep to the internal table along with instances of mainly trabecular and lamellar bone [ 2 ]. Although the cause of HFI is currently not agreed upon among researchers, some leading theories involve hormone irregularities and changes in diet [ 2 , 3 ]. While HFI is typically viewed as a benign condition, associated symptoms such as frontal lobe dysfunctions lead to questions about its clinical relevance [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Case Report of Hyperostosis Frontalis Interna

Álvarez¹,

Corrigan²,

Gardner³

2022

Cureus

View full text Add to dashboard Cite

A routine dissection of an 89-year-old female cadaver who had died of cardiopulmonary arrest revealed a unique case of hyperostosis frontalis interna (HFI). Multiple layers of spongy bone growth deep to the internal table were coupled with asymmetrical nodular growths. Slight superior sagittal sinus growth was also noted, which is atypical of this condition. Additionally, this cadaver represents one of the rarer and more severe forms of HFI, class C. A clear consensus on whether HFI presents a clinical risk has not been reached. We hope that this report on a unique manifestation of HFI will help clinicians in evaluating patients with this condition.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Case Report of Hyperostosis Frontalis Interna

Álvarez¹,

Corrigan²,

Gardner³

2022

Cureus

View full text Add to dashboard Cite

show abstract

“…The incidence rate ranges from 5% to 12% in the general population. 1 According to an archaeology survey, HFI occurs in 24% of women and 5.2% of men. 2 In the 1950s, HFI was considered an aspect of other syndromes, including Morgagni-Stewart-Morel syndrome, but it is currently thought to be an independent condition.…”

mentioning

confidence: 99%

“…Thus, the high prevalence of HFI may be related to oestrogen levels. 1 Previous Japanese reports of HFI [3][4][5] showed cognitive impairment; however, in almost all cases, a differential diagnosis was not considered for dementia. HFI does not cause significant clinical disease and is rarely encountered in Japan.…”

mentioning

confidence: 99%

Hyperostosis frontalis interna in a patient with Alzheimer's disease

et al. 2022

View full text Add to dashboard Cite

The clinical manifestations of hyperostosis frontalis interna: A qualitative systematic review of cases

Alvarez,

Corrigan,

McGonegal

et al. 2024

Clinical Anatomy

View full text Add to dashboard Cite

Hyperostosis frontalis interna (HFI) is a condition defined as abnormal bone growth on the posterior aspect of the frontal bone. Despite uncertainties regarding its etiology and prognosis, clinicians typically consider HFI a benign pathology. There are no studies organizing all the possible manifestations of the disease. The present study aims to organize all the clinical manifestations of HFI within the current case report/series literature. A blinded PRISMA‐guided search of HFI case reports and case series yielded 43 relevant articles and provided 110 patients for analysis. The symptoms presenting alongside HFI were extracted and tabulated. We found high‐frequency clinical manifestations of HFI (>20% of patients) to include headaches, obesity, vertigo/dizziness symptoms, cognitive decline, and depression. An additional 15 symptoms were tabulated at frequencies found to be less than 20%. Based on our analysis, we suggest the constellation of high‐frequency symptoms can offer a more comprehensive clinical picture of symptomatic HFI which may be valuable to consider for clinicians and future researchers in the field of HFI.

show abstract

A rare case of hyperostosis frontalis interna in an 86-year-old Japanese female cadaver

Cited by 3 publications

References 7 publications

A Case Report of Hyperostosis Frontalis Interna

A Case Report of Hyperostosis Frontalis Interna

Hyperostosis frontalis interna in a patient with Alzheimer's disease

The clinical manifestations of hyperostosis frontalis interna: A qualitative systematic review of cases

Contact Info

Product

Resources

About