A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer

Saeed, Muhammad; George, Geny; Lajara, Sigfred; Perkins, Bennal; Knight, Colette

doi:10.4158/ep161485.cr

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…This reflects the rarity of such association, and possibly the limited capacity of skin cancers to provoke overt PNS 2. Underlying predisposing factors to cSCC reported in those cases included: genodermatoses (dystrophic epidermolysis bullosa,8 porokeratosis of mibelli,9 xeroderma pigmentosum10) and acquired factors, for example, burn scars,11 hidradenitis suppurativa,12 chronic arsenic intoxication13 and lymphoedema 14…”

Section: Discussionmentioning

confidence: 99%

Humoral hypercalcaemia of malignancy associated with a gigantic cutaneous squamous cell carcinoma

et al. 2022

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Humoral hypercalcaemia of malignancy is rarely associated with cutaneous squamous cell carcinoma (SCC), and only a few cases have been reported in the medical literature. We present an interesting case of a gigantic cutaneous SCC associated with severe hypercalcaemia.A man in his mid 80s presented with a rapidly enlarging fungating mass of his scalp for 5 months. Laboratory studies logged severe hypercalcaemia, low intact parathyroid hormone, elevated parathyroid hormone related-peptide and normal 1,25 dihydroxy vitamin D. Skin biopsy revealed moderately differentiated invasive SCC. Further workup was negative for distant skeletal metastases. Severe hypercalcaemia was managed by intravenous fluids, bisphosphonates and calcitonin. A multidisciplinary approach was then made; the patient received radiotherapy and then underwent a successful surgical resection. By presenting this case, we aim to raise physicians’ awareness of the association between cutaneous SCC and hypercalcaemia. Severe hypercalcaemia should be detected early and promptly managed as it could be fatal.

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Section: Discussionmentioning

confidence: 99%

Humoral hypercalcaemia of malignancy associated with a gigantic cutaneous squamous cell carcinoma

et al. 2022

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“…Despite the high rate of hypercalcemia in malignancy in general, it is rare in cutaneous SCCs. There are reports of HHM arising from SCC transformation of chronic wounds such as decubitus ulcers 10 and burns; however, the association of HHM with HS-related SCC is even rarer.…”

Section: Discussionmentioning

confidence: 99%

A fatal case of parathyroid hormone–related peptide (PTHrP)-producing squamous cell carcinoma arising in the context of long-standing hidradenitis suppurativa

et al. 2018

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“…An additional search of the selected papers for similar material in MEDLINE via the Pubmed option “related links” did not yield any additional relevant material. A search based on the references lists of the selected publications yielded two additional relevant non-MEDLINE included publications [ 48 , 49 ], leading to a total of 40 papers reporting 41 PNS cases associated with KSC. The KSC were classified as primary, locally relapsed (after definite therapy and no evidence of metastases) or metastatic (with locoregional or distant metastases).…”

Section: Methodsmentioning

confidence: 99%

Paraneoplastic Syndromes in Patients with Keratinocyte Skin Cancer

Vlachos

Tziortzioti

Bassukas

2022

Cancers

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A variety of well-characterized cutaneous paraneoplastic syndromes (PNS) are diagnosed during internal malignancies; however, the spectrum of keratinocyte skin neoplasms (KSC) related to PNS is still obscure. The aim of the present review is to compile and evaluate the literature data on PNS associated with a keratinocyte skin neoplasm (KSC). Employing Pubmed, MEDLINE was searched for KSC-associated PNS reports. Forty relevant entries were assembled, reporting a total of 41 PNS cases associated with a KSC (34 male). No review paper compiling this topic was found. Six distinct PNS entities were identified, and malignancy associated hypercalcemia (MAH; 78%), anemia (10%) and Bazex syndrome (5%) were the most frequently reported among them. 85% of the PNS were reported in association with SCC, 10% with BCC, and the rest with adnexal tumors. The median age of the patients at the time of PNS diagnosis was 58 years (range: five–83 years). In most cases the PNS was diagnosed either concurrently or after the KSC diagnosis. KSC predisposing conditions, as scars (22%) or hidradenitis suppurativa (20%), were reported in >70% of the PNS cases. Most PNS resolved after KSC treatment. In conclusion, PNS of a rather limited spectrum of entities are reported in association with KSC. They also seem to be rare, possibly reflecting a limited capacity of KSC to provoke overt PNS.

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A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer

Cited by 4 publications

References 19 publications

Humoral hypercalcaemia of malignancy associated with a gigantic cutaneous squamous cell carcinoma

Humoral hypercalcaemia of malignancy associated with a gigantic cutaneous squamous cell carcinoma

A fatal case of parathyroid hormone–related peptide (PTHrP)-producing squamous cell carcinoma arising in the context of long-standing hidradenitis suppurativa

Paraneoplastic Syndromes in Patients with Keratinocyte Skin Cancer

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