A fatal case of parathyroid hormone–related peptide (PTHrP)-producing squamous cell carcinoma arising in the context of long-standing hidradenitis suppurativa

Pitch, Michelle; Bryan, Daniel J.; McMillan, Janice; Chávez, Luis Ángel Rodríguez; Hammes, Stephen R.; Scott, Glynis; Mercurio, Mary Gail; Somers, Kathryn

doi:10.1016/j.jdcr.2017.11.025

Cited by 5 publications

(2 citation statements)

References 10 publications

(11 reference statements)

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“…All the case reports and series met the minimum quality assessment standard and were included in the meta-analysis ( Supplementary Table S1 ) [ 2 , 6 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Selection bias cannot be excluded as most authors did not explicitly explain their selection method; therefore, there is a possibility that some cases of cSCC arising from HS wounds were not reported, underestimating the total number of cases currently in the literature.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa

Racanelli

Jfri

Gefri

et al. 2021

Cancers

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Background: Cutaneous squamous cell carcinoma (cSCC) is a rare complication of hidradenitis suppurativa (HS). Objectives: To conduct a systematic review and an individual patient data (IPD) meta-analysis to describe the clinical characteristics of HS patients developing cSCC and determine predictors of poor outcome. Methods: Medline/PubMed, Embase, and Web of Science were searched for studies reporting cSCC arising in patients with HS from inception to December 2019. A routine descriptive analysis, statistical hypothesis testing, and Kaplan–Meier survival curves/Cox proportional hazards regression models were performed. Results: A total of 34 case reports and series including 138 patients were included in the study. The majority of patients were males (81.6%), White (83.3%), and smokers (n = 22/27 reported) with a mean age of 53.5 years. Most patients had gluteal (87.8%), Hurley stage 3 HS (88.6%). The mean time from the diagnosis of HS to the development of cSCC was 24.7 years. Human papillomavirus was identified in 12/38 patients tested. Almost 50% of individuals had nodal metastasis and 31.3% had distant metastases. Half of the patients succumbed to their disease. Conclusions: cSCC is a rare but life-threatening complication seen in HS patients, mainly occurring in White males who are smokers with severe, long-standing gluteal HS. Regular clinical examination and biopsy of any suspicious lesions in high-risk patients should be considered. The use of HPV vaccination as a preventive and possibly curative method needs to be explored.

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Section: Resultsmentioning

confidence: 99%

Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa

Racanelli

Jfri

Gefri

et al. 2021

Cancers

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“…By evaluating the title/abstract information of the initially returned 831 papers we localized 53 articles with potentially relevant content for full-text search ( Figure 1 ). Of them, 15 were excluded (one was a duplicate publication, seven were cases of penile SCC, six were erroneously identified as reporting PNS in KSC and one reported no adequately personalized data) leaving to 39 papers reporting a total of 44 PNS cases associated with KSC [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. One paper ([ 47 ]) referred to five cases with relevant findings, however without any personalized data, and was excluded from this compilation, resulting in 38 papers reporting 39 relevant cases.…”

Section: Methodsmentioning

confidence: 99%

Paraneoplastic Syndromes in Patients with Keratinocyte Skin Cancer

Vlachos

Tziortzioti

Bassukas

2022

Cancers

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A variety of well-characterized cutaneous paraneoplastic syndromes (PNS) are diagnosed during internal malignancies; however, the spectrum of keratinocyte skin neoplasms (KSC) related to PNS is still obscure. The aim of the present review is to compile and evaluate the literature data on PNS associated with a keratinocyte skin neoplasm (KSC). Employing Pubmed, MEDLINE was searched for KSC-associated PNS reports. Forty relevant entries were assembled, reporting a total of 41 PNS cases associated with a KSC (34 male). No review paper compiling this topic was found. Six distinct PNS entities were identified, and malignancy associated hypercalcemia (MAH; 78%), anemia (10%) and Bazex syndrome (5%) were the most frequently reported among them. 85% of the PNS were reported in association with SCC, 10% with BCC, and the rest with adnexal tumors. The median age of the patients at the time of PNS diagnosis was 58 years (range: five–83 years). In most cases the PNS was diagnosed either concurrently or after the KSC diagnosis. KSC predisposing conditions, as scars (22%) or hidradenitis suppurativa (20%), were reported in >70% of the PNS cases. Most PNS resolved after KSC treatment. In conclusion, PNS of a rather limited spectrum of entities are reported in association with KSC. They also seem to be rare, possibly reflecting a limited capacity of KSC to provoke overt PNS.

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