A Rare Case of Disseminated Intravascular Coagulation Caused by the Nonionic Contrast Medium Iohexol

Shigyo, Masanori; Tsukamoto, Taiji; Yanase, Masahiro; Kumamoto, Yoshiaki; Aoki, Mamoru; Katsumata, Kazuaki

doi:10.1016/s0022-5347(01)67347-6

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…While the leucopenia and erytropenia have been reported to occur after CM injection in vivo (Levorstad et al., 1983; Hoffmann et al., 2000). Leucocytosis resulting from DIC caused by iohexol injection was also reported (Shıgyo et al., 1995). No haematological changes were reported in patients receiving doses of up to 6.25 gI/kg daily for four consecutive weeks (Morisetti et al., 1994).…”

Section: Discussionmentioning

confidence: 94%

“…Decrease in complement and total plasma protein was observed after injection of CM (Shigyo et al., 1995; Gardinali et al., 1997; Hoffmann et al., 2000). Fibrinogen is an important factor in the coagulation cascade.…”

Section: Discussionmentioning

confidence: 96%

“…A significant decrease on platelet counts has been observed after ionic and non‐ionic CM injections (Shıgyo et al., 1995; Hoffmann et al., 2000). This is contrast to the findings of (Kurisu and Tada, 1992) that no differences have been found regarding the platelet counts within the time intervals in each group and among the groups after ionic and non‐ionic CM injections.…”

Section: Discussionmentioning

confidence: 99%

“…From an in vivo study, it has been reported that no difference has been observed on FDP between the low osmolar ionic and non‐ionic CM (Hoffmann et al., 2000). Elevated level of FDP has been reported in iohexol‐induced disseminated intravascular coagulation (DIC) (Shigyo et al., 1995). The end product of fibrinolysis is FDP and formed by degradation of fibrin or fibrinogen or both.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Hyperosmolar Ionic and Low Osmolar Non‐ionic Contrast Media on Coagulation Times and Some Blood Parameters in Dogs: an In Vivo Study

Izci¹,

Oğurtan²,

Ceylan³

2003

Journal of Veterinary Medicine Series A

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The purpose of this study is to evaluate the effects of hyperosmolar ionic contrast media (CM) (diatrizoate) and low osmolar non-ionic CM (iohexol and ioxilan) on coagulation time and some blood parameters in dogs in vivo. The animals were divided into three groups in equal numbers. The dogs in groups I, II and III received diatrizoate, iohexol and ioxilan at the dose of 700 mgI/kg intravenously (IV) as a bolus, respectively. Administration of contrast media and blood samples were collected from vena cephalica antebrachii prior to CM administration and thereafter at 3, 15, 30, 60, 90 and 180 min and 24 h to measure the coagulation factors [activated partial thromboplastin time (APTT), prothorombin time (PT), fibrinogen and fibrinogen degradation products] and some other blood parameters [red blood cells, platelet, white blood cells, haematocrit (Ht) and haemoglobin (Hb)]. While a statistically significant decrease was observed on APTT at 15 min in group III, no significant differences were found in groups I and II. All the groups had insignificant alterations for PT, fibrinogen and fibrinogen degradation product, following CM administration. Significant decreases were observed for platelet at 3 min in all groups. This decrease was also significant at 15- and 30- min intervals in group I. There were significant decreases for erythrocytes, Ht and Hb measurements within 30 min, and no significant alterations were observed for leucocytes within 60 min in all groups compared with baseline values. No differences were observed with regard to coagulation times and some blood parameters as far as long-lasting and major effects of each CM are concerned.

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