A Rare Case of Diffuse Large B Cell Lymphoma Presenting as a Cardiac Mass

Yousif, Patrick; Kotecha, Aditya; Thakur, Ajit; Ismail, Hassan

doi:10.12659/ajcr.917159

Cited by 8 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cardiac involvement by NHL is rare, and to be presented as intracardiac mass is extremely rare. It could be a primary cardiac lymphoma or mediastinal mass with direct extension and in ltration into the right atrium giving a picture of intracardiac mass (3)(4)(5)(6). The prognosis of both subtypes are poor due to rapid progression and invasion of the disease with detection usually in the late stage of the disease (10,11).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diffuse Large B Cell Lymphoma with uncommon cardiac invasion: Case Report from Palestine

Daralammouri¹,

Hamayel²,

Ismail³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Diffuse large B cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma. Secondary involvement of the heart is seen late in advanced cases and it is uncommon for DLBCL to present as a cardiac mass.Case Presentation: A 26-year-old female patient presented with progressive shortness of breath, facial swelling, and lower limb swelling. Echocardiography showed a large right atrial mass that was obstructing the tricuspid valve. Computed topography (CT) scan confirmed the findings and a large mediastinal mass with a filling defect in the right atrium occluding the distal Superior Vena Cava was identified. Histopathology showed DLBCL. She received 6 cycles R-CHOP chemotherapy (rituximab, cyclophosphamide, epirubicin, vincristine, and prednisone) with good response and complete resolution of the mass.Conclusions: DLBCL can present with atypical, uncommon sites as the first presentation, such as the heart. Early diagnosis and appropriate management is crucial given the poor outcome with late presentation. A high index of suspicion and the proper investigations including CT scan is recommended to allow for early intervention and favorable outcomes as what happened with the case under discussion.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Intra-cardiac mass is a very rare presentation of DLBL (3)(4)(5)(6). This is a case report of a 26-year-old immunocompetent female patient presenting with gross intracardiac mass and Superior Vena Cava syndrome.…”

Section: Introductionmentioning

confidence: 94%

Diffuse Large B Cell Lymphoma with uncommon cardiac invasion: Case Report from Palestine

Daralammouri¹,

Hamayel²,

Ismail³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The right atrium [24] and ventricle are usually involved [25], and biatrial cases were reported [26]. Rare sporadic PCLs were reported in the left ventricle [27].…”

Section: Discussionmentioning

confidence: 99%

Primary cardiac tumors: a spectrum of pathologies and scenarios

et al. 2020

View full text Add to dashboard Cite

Background: Cardiac tumors are rare, and their diagnosis is challenging. The level of evidence for the management of cardiac tumors came from case reports or small case series. We aim to present our multicenter experience in the diagnosis and management of cardiac tumors. Results: We performed a prospective study, including 82 cases of cardiac tumors encountered at three centers in 5 years. The mean age was 62 ± 5.8 years old (range 2 months-74 years), and 91.4% were females constituted. The median EuroSCORE II was 4.27%. All cases underwent radical excision of the tumor. Five cases underwent additional mitral valve replacement and one case underwent coronary bypass grafting. Pathological diagnoses were left atrial myxomas (n = 65, 79.3%), right atrial myxomas (n = 5, 6.1%), bi-atrial myxomas (n = 2, 2.4%), right ventricular outflow tract myxoma (n = 1, 1.2%), myxosarcoma (n = 1, 1.2%), thymoma (n = 1, 1.2%), recurrent hemangioendothelioma (n = 1, 1.2%), round cell tumor (n = 1, 1.2%), cardiac lymphoma (n = 1, 1.2%), rhabdomyomas (n = 2, 2.4%), and renal cell carcinomas (n = 2, 2.4%). Two patients (2.4%) had re-exploration for bleeding. One patient (1.2%) with right atrial thymoma experienced a severe vasoplegia with unstable hemodynamics. Two patients had operative mortality (2.4%), one with recurrent cardiac hemangioendothelioma. During 1-year follow-up, one patient (1.2%) died because of metastatic myosarcoma. Recurrence was reported in 2 patients (2.4%). Conclusions: The clinical scenario of cardiac tumors depends mainly on tumor location and size rather than the histopathology. Surgical resection is feasible in benign tumors while very challenging in malignant tumors.

show abstract

“…However, echocardiography still showed extensive involvement in the aorta, peripulmonary arteries, left ventricle, and left atrium ( Figure 2D ), suggesting a poor prognosis. 5 One month after this follow-up, the patient succumbed to death owing to a sudden episode of ventricular tachycardia, ventricular fibrillation, and decreased blood pressure despite resuscitation efforts ( Figure 3 ).…”

Section: Case Presentationmentioning

confidence: 99%

Diffuse Large B-Cell Lymphoma With Cardiac Invasion Presented as Acute Myocardial Infarction and Left Ventricular Hypertrophy: A Case Report

Liu,

Pan,

et al. 2024

Journal of Investigative Medicine High Impact Case Reports

View full text Add to dashboard Cite

Primary cardiac lymphoma is an exceedingly rare malignant tumor, with diffuse large B-cell lymphoma (DLBCL) being the most prevalent histological subtype. This disease has non-specific clinical manifestations, making early diagnosis crucial. However, DLBCL diagnosis is commonly delayed, and its prognosis is typically poor. Herein, we report the case of a 51-year-old male patient with DLBCL who presented with recurrent chest tightness for 4 months as the primary clinical symptom. The patient was admitted to the hospital and diagnosed with acute myocardial infarction and left ventricular hypertrophy with heart failure. Echocardiography revealed a progression from left ventricular thickening to local pericardial thickening and adhesion in the inferior and lateral walls of the left ventricle. Finally, pathological analysis of myocardial biopsy confirmed the diagnosis of DLBCL. After treatment with the R-CHOP chemotherapy regimen, the patient’s chest tightness improved, and he was discharged. After 2 months, the patient succumbed to death owing to sudden ventricular tachycardia, ventricular fibrillation, and decreased blood pressure despite rescue efforts. Transthoracic echocardiography is inevitable for the early diagnosis of DLBCL, as it can narrow the differential and guide further investigations and interventions, thereby improving the survival of these patients.

show abstract

A Rare Case of Diffuse Large B Cell Lymphoma Presenting as a Cardiac Mass

Cited by 8 publications

References 10 publications

Diffuse Large B Cell Lymphoma with uncommon cardiac invasion: Case Report from Palestine

Diffuse Large B Cell Lymphoma with uncommon cardiac invasion: Case Report from Palestine

Primary cardiac tumors: a spectrum of pathologies and scenarios

Diffuse Large B-Cell Lymphoma With Cardiac Invasion Presented as Acute Myocardial Infarction and Left Ventricular Hypertrophy: A Case Report

Contact Info

Product

Resources

About