Primary cardiac hemangioendothelioma is a very rare tumor. Up to now, <20 cases have been reported worldwide; involvement of mitral valve by the tumor is extremely rare. In this report, a case of hemangioendothelioma arose from the mitral valve and was successfully resected, and after few months the tumor recurred and infiltrated the heart.
In Egypt, The prevalence of chronic heart disease (CHD) is 8.3%. It is the principal cause of death and is responsible for 22% of total mortality. The age-adjusted mortality rate is 174 per 100,000 of population. There are many studies on traditional risk factors and CHD in Egypt but the study of novel risk factors is deficient.ObjectivesThe aim of the present case control study was to investigate the relation between CHD susceptibility and Endothelial Nitric Oxide Synthase (eNOS) Glu 298 Asp (G894T) and Apolipoprotein E (ApoE) gene polymorphism in a cohort of Egyptian individuals.MethodsGenotyping of eNOS (Glu298Asp) and Apo E genes polymorphisms were done using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method for 100 CHD cases and 100 age and sex matched healthy controls.ResultsA statistically significant association was observed between GT and TT genotypes of endothelial nitric oxide synthase gene with CHD with OR = 2.03 and 3.5; respectively. Also, carriers of E4 allele and especially E3/E4 genotype were at higher risk of CHD with OR = 3.3 for both. Significant association was also observed between the presence of combined GTE3E4 genotype and CHD with OR = 6.6.ConclusionGT and TT genotypes of endothelial nitric oxide synthase gene, E3/E4 genotype of Apo E gene polymorphism and combined GTE3E4 genotype can be considered risk factors for the development of CHD among Egyptians.
Background: Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide. There are many risk factors for CHD but recently the role of oxidative stress in progression of atherosclerosis has been more recognized. Paraoxonase 1 (PON1) protects against oxidation of LDL and many polymorphisms in both of exons and promoter regions of (PON1) gene have been investigated for their association with CHD. The aim of the present study was to investigate the relation between CHD suceptibility and PON1 Q192R (A/G) gene polymorphism in a cohort of Egyptian individuals. Methods: The study included 100 subjects, 50 patients who admitted to cardiovascular department with established diagnosis of obstructive coronary artery disease by coronary angiography and 50 healthy participants. Genotyping of PON1 Q192R (A/G) was done, and then serum concentration of PON1 was assessed by ELISA after that by spectrophotometer. Results: Serum PON1 enzyme was lower in patients with CHD than in control group with a statistically significant difference p < 0.001. A statistically significant association was observed with AG and GG genotypes of PON1 gene with CHD with P= 0.003, OR=5.02(95% CI =1.66-15.26) and P= 0.038, OR= 9.4 (95% CI =1.07-82.5); respectively. The G allele of PON1 was higher in CHD patients than controls suggesting that this allele may demonstrate a susceptibility effect to CHD in our cohort with P<0.001, OR= 5.16 (95% CI = 2.1-12.5) Conclusion: The Q192R polymorphism in the PON1 gene may be a susceptibility gene associated with increased risk of CHD among Egyptians.
Purpose We aimed to compare the procedural and short-term outcomes between IVUS guided and OCT guided percutaneous coronary interventions in patients presenting with acute coronary syndrome (ACS). Methods In the present retrospective study, we reviewed the data of 50 patients who had IVUS-guided PCI and 50 patients who had OCT-guided PCI for ACS between January 2021 and June 2021. Intravascular imaging was done before and after stenting. Both groups were compared in terms of minimal luminal area (MLA), stent dimensions, final minimal stent area (MSA) and stent expansion as well as negative angiographic outcomes. Patients were followed for six months to record MACE. Results The mean age of analyzed patients was 57 ± 13 years with male predominance (78%). The radiation time and dose were significantly higher among IVUS group. Pre-stenting MLA was significantly higher in IVUS group (2.63mm vs 2.22 mm in OCT, P = 0.013). Stent expansion was significantly higher among OCT group (97% vs 93% in IVUS group, P = 0.001) with no significant difference between both groups regarding MSA [mm2] (8.88 ± 2.87 in IVUS vs 8.1 ± 2.76 in OCT, P = 0.169). No significant difference between both groups was noted regarding contrast volume, edge dissection and no reflow. The rates of six-months MACE were significantly higher in the IVUS group. Conclusion OCT-guided PCI in ACS is safe and associated with similar MSA to that of IVUS-guided PCI.
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