A Rare Case of ARDS Caused by Bupropion Inhalation and Treated with Noninvasive Ventilation

Abstract

Acute respiratory distress syndrome, characterized by the Berlin criteria, is associated with a high mortality rate. Its treatment includes addressing the underlying etiology, general supportive measures, and achievement of effective oxygenation. New key data indicates that in a subset of patients, noninvasive ventilation techniques can be a therapeutic and equivalent alternative to traditional invasive ventilation. We present a rare case of ARDS triggered by nasal bupropion inhalation and effectively treated with noninvasive positive pressure ventilation resulting in complete resolution.

A Systematic Review of Abuse or Overprescription of Bupropion in American Prisons and a Synthesis of Case Reports on Bupropion Abuse in American Prison and Non-prison Systems

“…The most common psychiatric condition seen in our case report synthesis was substance use disorder, which included cocaine (six cases) [24,26,27,30,37], opioids (three cases) [20,26,34], amphetamines/methamphetamine (three cases) [27,36,37], and alcohol (three cases) [26,31,37]. Other psychiatric comorbidities and clinical signs comprised bipolar disorder (three cases) [20,25,37] and depression (seven cases) [20,[26][27][28]30,36,39].…”

“…The most common route for bupropion use was nasal insufflation (seen in 11 cases ) [24][25][26][27][28][29][30][31][32][33][34], followed by the oral route (seen in seven cases) [35][36][37][38]. IV administration was observed in two cases [20,39], while two other cases did not report the route of administration [28,40].…”