A Rare Case of Amyopathic Juvenile Dermatomyositis Associated With Psoriasis Successfully Treated With Ustekinumab

Montoya, Claudia; González, Martha Lucía; Ospina, Fabio E.; Tobón, Gabriel J.

doi:10.1097/rhu.0000000000000430

Cited by 18 publications

(21 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Co-existence of psoriasis and DM is extremely rare, and only several cases have been reported [63][64][65][66][67]. Clinically, keratotic erythemas are frequently observed on the extensor aspect of the elbows and knees in both diseases.…”

Section: Psoriasis and Dmmentioning

confidence: 99%

Psoriasis and Connective Tissue Diseases

Yamamoto

2020

IJMS

View full text Add to dashboard Cite

Psoriasis is a chronic systemic inflammatory disease with various co-morbidities, having been recently considered as a comprehensive disease named psoriatic disease or psoriatic syndrome. Autoimmune diseases are one form of its co-morbidities. In addition to the genetic background, shared pathogenesis including innate immunity, neutrophil extracellular trap (NETs), and type I interferon, as well as acquitted immunity such as T helper-17 (Th17) related cytokines are speculated to play a significant role in both psoriasis and connective tissue diseases. On the other hand, there are definite differences between psoriasis and connective tissue diseases, such as their pathomechanisms and response to drugs. Therefore, we cannot expect that one stone kills two birds, and thus caution is necessary when considering whether the administered drug for one disease is effective or not for another disease. In this review, several connective tissue diseases and related diseases are discussed from the viewpoint of their coexistence with psoriasis.

show abstract

Section: Psoriasis and Dmmentioning

confidence: 99%

Psoriasis and Connective Tissue Diseases

Yamamoto

2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Seven cases developed dermatomyositis prior to psoriasis, and psoriasis preceded in the rest of the cases. Besides these, one case coexisted with interstitial pneumonia, the other one coexisted with Hashimoto's thyroiditis, Sjogren syndrome, and another case coexisted with corticosteroid‐induced diabetes and systemic hypertension . Referring to the pathogenesis, sufficient evidence suggested that the dermatomyositis and psoriasis shared some common inflammatory pathways, including interferon (IFN)‐α/β‐induced response, INF‐γ, and tumor necrosis factor (TNF)‐α.…”

Section: Discussionmentioning

confidence: 99%

“…Ustekinumab has proved to be effective in the treatment of moderate to severe psoriasis and active psoriatic arthritis . It has also been reported that ustekinumab was effective in treating the co‐existence of dermatomyositis and psoriasis . Intravenous immunoglobulin was a safe choice for refractory dermatomyositis, but it was also reported that intravenous immunoglobulin induces severe relapse of psoriasis .…”

Section: Discussionmentioning

confidence: 99%

Co‐existence of Juvenile dermatomyositis and psoriasis vulgaris with fungal infection: A case report and literature review

Xing

Xie

Jiang

et al. 2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Summary Introduction The incidence rate of psoriasis vulgaris (PSV) coexisting with Juvenile dermatomyositis (JDM) is low. Through our thorough literature search, we found that PSV arising on JDM with superficial fungal infection of facial skin is rarely reported. So, we hereby, report a case of combination of the above three diseases. Meanwhile, we also reviewed the previous literatures aiming at the related basis, clinical manifestation, diagnosis, and treatment of the diseases. Interestingly, of all cases, this case is the only one in which the symptom of muscle weakness preceded the appearance of rash. Case Presentation A 21‐year‐old man diagnosed with JDM 6 years ago came to our inpatient department due to the appearance of new rash. Skin examination showed some sharply demarcated scaly plaques over the head, neck, torso, and bilateral upper limbs with pruritus and scaling. Histological examination and typical clinical manifestation confirmed the diagnosis of PSV for his new rash. Family history was negative for JDM and PSV. The clear erythema located on his face revealed the existence of superficial fungal infection with the help of fungal fluorescence microscopy. He had marked improvement of his symptoms with the treatment given at our department. In the past 3 months, the patient has been on regular follow‐up at our outpatient department, and his condition is stable at present. Discussion This paper presents a case of PSV arising on JDM coexisting with superficial fungal infection on the face hoping that this will help clinicians in the better diagnosis of the diseases during literature search.

show abstract

“…All three patients in the report by Nikki and co‐authors were under the age of 18 and showed proximal muscle weakness and were treated with a combination therapy of methotrexate and methylprednisolone. In addition, one report demonstrates a patient at the age of 20 who had amyopathic juvenile dermatomyositis with psoriasis . Current treatment options recommend the use of a steroid‐pulse therapy with 30 mg/kg with a 1‐g maximum dosage on several occasions in conjunction with oral administration of prednisone 0.5 mg/kg/d alone, or in combination with other immunosuppressants such as methotrexate .…”

Section: Discussionmentioning

confidence: 99%