Psoriasis and Connective Tissue Diseases

Yamamoto, Toshiyuki

doi:10.3390/ijms21165803

Cited by 19 publications

(11 citation statements)

References 99 publications

(109 reference statements)

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“…This is likely to reflect the different clinical and etiopathological features between DLE and psoriasis. Indeed, contrary to DLE lesions, psoriatic plaques do not lead to hair loss or epidermal atrophy [ 32 ], and antimalarial drugs may exacerbate the disease. Additionally, activation of the IFN-γ pathway is more predominant in DLE rather than psoriasis, which is characterized by a Th17-skewed signature [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Macrophage Migration Inhibitory Factor (MIF) and Its Homologue D-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus

et al. 2021

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Discoid Lupus Erythematosus (DLE) is a chronic cutaneous disease of unknown etiology and of immunoinflammatory origin that is characterized by inflammatory plaques and may lead to disfiguring scarring and skin atrophy. Current treatments are limited, with a large proportion of patients either poorly or not responsive, which makes DLE an unmet medical need. Macrophage migration inhibitory factor (MIF) is the prototype of a pleiotropic family of cytokine that also includes the recently discovered homologue D-dopachrome tautomerase (DDT) or MIF2. MIF and DDT/MIF-2 exert several biological properties, primarily, but not exclusively of a proinflammatory nature. MIF and DDT have been suggested to play a key role in the pathogenesis of several autoimmune diseases, such as multiple sclerosis and type 1 diabetes, as well as in the development and progression of certain forms of cancers. In the present study, we have performed an immunohistochemistry analysis for the evaluation of MIF in DLE lesions and normal skin. We found high levels of MIF in the basal layer of the epidermis as well as in the cutaneous appendage (eccrine glands and sebocytes) of normal skin. In DLE lesions, we observed a significant negative correlation between the expression of MIF and the severity of inflammation. In addition, we performed an analysis of MIF and DDT expression levels in the skin of DLE patients in a publicly available microarray dataset. Interestingly, while these in silico data only evidenced a trend toward reduced levels of MIF, they demonstrated a significant pattern of expression and correlation of DDT with inflammatory infiltrates in DLE skins. Overall, our data support a protective role for endogenous MIF and possibly DDT in the regulation of homeostasis and inflammation in the skin and open up novel avenues for the treatment of DLE.

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Section: Discussionmentioning

confidence: 99%

Macrophage Migration Inhibitory Factor (MIF) and Its Homologue D-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus

et al. 2021

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“…However, unrestrained innate immune responses (autoinflammation) remain an essential pathological component because nonspecific stimuli, such as trauma, bacterial/viral infection, or drugs, evoke tissue imprinted immunological memory [ 74 ]. The quintessential clinical observation is the Köbner phenomenon [ 75 ]. Rodent models are vital tools for drug development and experimental pathology.…”

Section: Epidermal Differentiation and Skin Diseasesmentioning

confidence: 99%

The Epidermis: Redox Governor of Health and Diseases

Ishitsuka

Roop

2021

Antioxidants

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A functional epithelial barrier necessitates protection against dehydration, and ichthyoses are caused by defects in maintaining the permeability barrier in the stratum corneum (SC), the uppermost protective layer composed of dead cells and secretory materials from the living layer stratum granulosum (SG). We have found that loricrin (LOR) is an essential effector of cornification that occurs in the uppermost layer of SG (SG1). LOR promotes the maturation of corneocytes and extracellular adhesion structure through organizing disulfide cross-linkages, albeit being dispensable for the SC permeability barrier. This review takes psoriasis and AD as the prototype of impaired cornification. Despite exhibiting immunological traits that oppose each other, both conditions share the epidermal differentiation complex as a susceptible locus. We also review recent mechanistic insights on skin diseases, focusing on the Kelch-like erythroid cell-derived protein with the cap “n” collar homology-associated protein 1/NFE2-related factor 2 signaling pathway, as they coordinate the epidermis-intrinsic xenobiotic metabolism. Finally, we refine the theoretical framework of thiol-mediated crosstalk between keratinocytes and leukocytes in the epidermis that was put forward earlier.

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“…There was significant reduction in PASI scores after treatment (p<0.001). The mean percentage of improvement (reduction in PASI scores) after treatment was 71.1% Table (3).…”

Section: Clinical Improvementmentioning

confidence: 99%

“…The plaques can coalesce and cover large areas of skin. Common locations include the trunk, the extensor surfaces of the limbs, and the scalp [3] Psoriatic arthritis (PsA) is an inflammatory arthritis occurring either during the course of cutaneous psoriasis or without cutaneous psoriasis and characterized by negative rheumatoid factor. PsA may develop in up to 30% of psoriatic patients [4] Pustular psoriasis is classified into two main groups A. Generalized pustular psoriasis (Von Zumbusch): This form is characterized by the rapid development of widespread tender erythema followed by an eruption of 1-2 mm pustules.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting response to psoriasis treatment

Elesawy

Salem

Elsayed

et al. 2021

Benha Journal of Applied Sciences

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Psoriasis is a common chronic, recurrent, immune mediated disease of the skin and joints. It can have a significant negative impact on the physical, emotional, and, psychosocial wellbeing of affected patients. Psoriasis is found worldwide but the prevalence varies among different ethnic groups. It has a strong genetic component but environmental factors such as infections can play an important role in the presentation of disease. There are several clinical cutaneous manifestations of psoriasis but most commonly the disease presents as chronic, symmetrical, erythematous, scaling papules and plaques. Methotrexate (MTX) has remained the backbone of the treatment for moderate to severe psoriasis ever since its first use nearly half a century ago. Over the years, its high efficacy, low cost, relative ease of administration and usefulness in concomitant psoriatic arthritis have contributed in making MTX the drug of choice in managing severe psoriasis. Although the majority of patients achieve remission of disease activity with MTX, a significant proportion may experience mild and transient adverse effects. In this study, it was aimed to evaluate the factors which affecting response to psoriasis treatment. The study included 28 patients suffering from psoriasis and 30 healthy control subjects of different age, sex, disease duration and PASI score.

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Psoriasis and Connective Tissue Diseases

Cited by 19 publications

References 99 publications

Macrophage Migration Inhibitory Factor (MIF) and Its Homologue D-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus

Macrophage Migration Inhibitory Factor (MIF) and Its Homologue D-Dopachrome Tautomerase (DDT) Inversely Correlate with Inflammation in Discoid Lupus Erythematosus

The Epidermis: Redox Governor of Health and Diseases

Factors affecting response to psoriasis treatment

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