A Rare Case of Adult Medulloblastoma with Spinal Metastasis

Quenum, Kisito; Ntalaja, J. Mukengeshay; Onen, Justin; Arkha, Yasser; Derraz, S.; Ouahabi, Abdeldjalil; Sefiani, S.; Elkhamlichi, Amina

doi:10.1155/2012/748601

Cited by 4 publications

(8 citation statements)

References 12 publications

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“…More common in children (75%) with predominance of men [5].The postoperative delay for metastases in the literature is approximately 18 months [6]. Metastases can be localized in the central nervous system via the circulation of malignant cells in the CSF: more frequently leptomeningeal and spinal more rarely supratentorial (fronto-basal ++) (Figures 3 A, B, C) More rarely in extra-neuraxis: bones, ganglia, peritoneum, liver and lung.…”

Section: Discussionmentioning

confidence: 99%

Management of Medulloblastoma Metastases: Algerian Experience

Badache¹

2021

J Oncol Res Rev Rep

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This work is based on the study of patients treated for medulloblastoma metastasis at diagnosis between January 2006 and December 2015 in the neurosurgery department of the Ait IDDIR Health Hospital Establishment. Our series consisted of 16 patients, 11 men and 5 women; the median age was 16.9 years. The baseline, presentation of symptoms and signs, imaging results (MRI), surgical results and clinical results were recorded. The clinical manifestation was revealed by intracranial hypertension syndrome (100%), associated with cerebellar syndrome (80%). The localization was in Intra-nevraxics: (81.25%) and in Extra-nevraxics (18.75%). 68.75% of patients underwent total surgical excision and 31.25% underwent subtotal surgical excision. The presence of malignant cells in the CSF is marked in 56.25%. The pathological study revealed that 62.5% of cases had a classic variant and 37.5% a desmoplastic variant. 30% of the cases were classified as “standard risk” and 70% as “high risk”. The surgery was supplemented by radiotherapy of the entire neuraxis using the “movable junctions” technique in all cases. The average delay was 70 days. Adjuvant chemotherapy was performed in 9 cases. The long-term survival rate after metastasis varies between 06 months to 24 months, only 04 cases (25%) are still alive. The management of medulloblastoma must be multidisciplinary involving neurosurgeons and radiotherapist oncologists. This collaboration is the only guarantee of an improvement in his prognosis

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Section: Discussionmentioning

confidence: 99%

Management of Medulloblastoma Metastases: Algerian Experience

Badache¹

2021

J Oncol Res Rev Rep

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“…The most common position of this tumor is the posterior cranial fossa. This tumor contains about 21.8% all primary malignant tumors of the nervous system in Iran (2). Medulloblastoma as a primary tumor of cerebellum includes about 20% of pediatric tumors and 1% of adult brain tumors (2).…”

Section: Introductionmentioning

confidence: 99%

“…This tumor contains about 21.8% all primary malignant tumors of the nervous system in Iran (2). Medulloblastoma as a primary tumor of cerebellum includes about 20% of pediatric tumors and 1% of adult brain tumors (2). Due to advances in surgery, chemotherapy and radiotherapy, the prognosis of medulloblastoma has dramatically changed in the last 20 years.…”

Section: Introductionmentioning

confidence: 99%

“…Due to advances in surgery, chemotherapy and radiotherapy, the prognosis of medulloblastoma has dramatically changed in the last 20 years. The disease-free survival of patients is approximately 10 years in the absence of spinal metastases (2). The most common sites of systemic metastasis are bone, peritoneum, liver and lung but the overall systemic metastasis rarely occurs in a small number of patients and it has rarely been reported medulloblastoma with metastases in the spinal cord (2).…”

Section: Introductionmentioning

confidence: 99%

“…The disease-free survival of patients is approximately 10 years in the absence of spinal metastases (2). The most common sites of systemic metastasis are bone, peritoneum, liver and lung but the overall systemic metastasis rarely occurs in a small number of patients and it has rarely been reported medulloblastoma with metastases in the spinal cord (2). In the recent years, the survival rate of children with medulloblastoma show better results.…”

Section: Introductionmentioning

confidence: 99%

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Low Back Pain and Paraplegia as Initial Clinical Presenting of Medulloblastoma: A Case Report

et al. 2018

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Introduction: Medulloblastoma is one of the most common malignancies in children. Common clinical symptoms of patients are related to the symptoms due to tumor in the posterior cranial fossa. Presentation of patients with symptoms related to metastatic tumors in the spinal canal are unusual. Case Presentation: We present a 6-year-old child with symptoms of lower back pain and Paraplegia as early symptoms of medulloblastom. The Magnetic Resonance Image (MRI) of spinal cord revealed multiple tumors in the spinal canal (initially diagnosed). A biopsy of the tumor was also performed. Then, whole CNS (Central Nervous System) imaging revealed tumor in the posterior cranial fossa. He had a dramatic improvement after treatment and returned to normal in all clinical signs. Four years have passed from his treatment and he is symptom free. Conclusions: Presentation of Medulloblastoma with widespread spinal canal drop metastases is rare. However, spinal drop metastasis should be considered to prevent a suboptimal management in child. These patients did not consider in aspect of the treatment outcome as hopeless.

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