Medulloblastoma metastatic to the pancreas: a case report

Gavini, Hemanth; Arukala, Venkat D.; Stewart, John; Lee, Jeffrey H.

doi:10.1016/j.gii.2014.09.007

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…MB CTCs display positivity for CD56 (NCAM), which, coupled with CD45 exclusion (to exclude white blood cells) and morphological examination, allows the identification of such cells. CD56+ve MB cells are also found in the blood of patients that display overt extraneural disease at progression, indicating that the expression of the antigen is conserved at relapse and could be useful for tracking MB CTCs during the entire course of the disease (17,23,92). However, efforts to characterize the surfaceome of MB CTCs should be undertaken, because expression of CD56 is frequently focal in primary tumors.…”

Section: Anatomic Routes Of Metastatic Disseminationmentioning

confidence: 99%

The molecular biology of medulloblastoma metastasis

et al. 2020

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Medulloblastoma (MB) is the most common primary malignant brain tumor of childhood and a significant contributor to pediatric morbidity and death. While metastatic dissemination is the predominant cause of morbidity and mortality for patients with this disease, most research efforts and clinical trials to date have focused on the primary tumor; this is due mostly to the paucity of metastatic tumor samples and lack of robust mouse models of MB dissemination. Most current insights into the molecular drivers of metastasis have been derived from comparative molecular studies of metastatic and non-metastatic primary tumors. However, small studies on matched primary and metastatic tissues and recently developed mouse models of dissemination have begun to uncover the molecular biology of MB metastasis more directly. With respect to anatomical routes of dissemination, a hematogenous route for MB metastasis has recently been demonstrated, opening new avenues of investigation. The tumor micro-environment of the primary and metastatic niches has also been increasingly scrutinized in recent years, and further investigation of these tumor compartments is likely to result in a better understanding of the molecular mediators of MB colonization and growth in metastatic compartments.

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Section: Anatomic Routes Of Metastatic Disseminationmentioning

confidence: 99%

The molecular biology of medulloblastoma metastasis

et al. 2020

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“…При этом встречаются сообщения о вторичном поражении ПЖ и более редкими опухолями, например, медуллобластомой, семиномой и др. [9,17].…”

Section: возможности цитологического метода исследования в диагностик...unclassified

Opportunities in Diagnostics of Pancreatic Metastatic Tumors by Cytological Method

Михетько¹,

Ivko²,

Petrik³

et al. 2019

Problems in oncology

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Our study includes results of 152 pancreatic fine needle aspirations of solid and cystic tumors, from 149 patients of the N.N. Petrov Cancer Research Center for the 3-year period (2016 - 2018). Representative cell material for morphological studies was obtained in 97.4% of cases. The results of cytological examination of 111 patients with pancreatic tumors were compared with histological data. The effectiveness of cytological examination was 96.1%, sensitivity - 95.6%, specificity -100%. Metastatic lesions were presented in 9% (9 patients). In 9 diagnostically proven cases, the cytological result was correct 8 times. Cytological examination with immunocytochemistry is a valid and accurate diagnostic procedure for the evaluation of pancreatic tumors including metastatic lesions.

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Medulloblastoma metastatic to the pancreas: a case report

Cited by 2 publications

References 16 publications

The molecular biology of medulloblastoma metastasis

The molecular biology of medulloblastoma metastasis

Opportunities in Diagnostics of Pancreatic Metastatic Tumors by Cytological Method

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