A rare case of a myofibroma presenting on the tongue

Abstract

Myofibromas are benign neoplasms of myofibroblastic origin, rarely encountered in the oral cavity. Limited awareness of the clinical features of these lesions risks misdiagnosis of more sinister pathology. The objective of this report is to highlight the potential diversity of oral lesions by describing an uncommon presentation of a myofibroma. The case reveals the diagnostic difficulties encountered, along with postoperative complications, which exemplify the remarkable healing capacity of the oral cavity.

Clinicopathological features of myofibromas and myofibromatosis affecting the oral and maxillofacial region: A systematic review

“…1,6 While soft tissue lesions mimic benign neoplasms due to their painless and slow growing characteristics, intra-osseous lesions usually destroy the adjacent bone, mimicking odontogenic tumors or malignant neoplasms. 1,6,7 Regardless of the type of lesion-soft tissue or intraosseous MF/MFT-the main clinical characteristic of our cases was a painless, slow growing mass. A benign neoplasm was the main diagnostic hypothesis among the cases of this systematic review, in addition to some characteristics of the bone lesions such as osseous destruction.…”

“…The only patient that reported other body lesions was a boy, in agreement with the findings reported by Scheper et al 15 The literature shows that MF and MFT lesions may occur within a wide age range, being more common among infants and children. 7,9 The age of the patients included in this review showed a wide range.…”

“…[3][4][5] MF most commonly occurs in the soft tissues of the head and neck region and almost 90% of the cases occur in patients under 2 years old. [6][7][8] Currently, the World Health Organization (WHO) accepts the terminology of MF for a solitary lesion and myofibromatosis (MFT) for its multicentric counterpart. 6,8,9 Oral and maxillofacial region involvement by MF and MFT is rare.…”

“…Similarly, in the jaws the lesions generally show a slow and asymptomatic growth that may cause perforation and destruction of cortical bone, mimicking odontogenic tumors and malignant neoplasms. 1,7 Regarding its histopathological features, MF usually appear as nodular neoplasms showing a distinctive biphasic pattern-with a light-(spindle-cells) and dark-(round cells) stained appearance-and generally does not exhibit significant atypia, pleomorphism, or abnormal mitotic activity. 10,11 Previous articles on oral soft tissue/intra-osseous MF and oral involvement of MFT are mostly sporadic case reports.…”

O papel do odontopediatra no diagnóstico de tumores orais: relato de caso

“…Apesar dos diversos diagnósticos diferenciais, a análise imuno-histoquímica é uma importante ferramenta para conclusão de um diagnóstico definitivo (CHATTARAJ M, et al, 2017; PEREIRA DE OLIVEIRA DHI, et al, 2019). Através da análise dos dados da imuno-histoquímica, o caso apresentado neste estudo possui uma concordância com a literatura, apresentando positividade para os antígenos de actina de músculos lisos, vimentina e HHF-35 e negatividade para desmina, S-100 e Ki-67 ( As complicações relacionadas ao tratamento do Miofibroma pouco são relatadas na literatura, geralmente quando a um envolvimento de um nervo pelo Miofibroma, levando a um dano do nervo ou sua remoção por parte do procedimento cirúrgico (SHARIFI A, et al, 2015;SHIBUYA Y, et al, 2008). No presente caso foi observado uma paralisia unilateral do nervo marginal da mandíbula, consequentemente a diminuição da motricidade da musculatura da mímica facial da região onde encontrava-se a lesão.…”