Lesions of the Oral Cavity

Montague, L.; Clark, Ashley K.; Bouquot, Jerry E.

doi:10.1016/b978-0-323-53114-6.00004-3

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“…Solitary neurofibromas not associated with NF 1 rarely become malignant, but when associated with the NF1 syndrome, they has the potential for malignant transformation. It has been reported that 12% of patients with neurofibromatosis type 1 will eventually develop malignant nerve sheath tumors from the neurofibromas of the oral cavity [ 13 ]. Solitary diffuse neurofibromas can also have the risk of undergoing malignant change, although the quantification of such risk has not been determined [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Ankle Swelling in Patients With Type 1 Neurofibromatosis: A Report of Two Cases With Rare Presentation of Common Genodermatosis

Thomas¹,

Balasundaram²,

James³

et al. 2022

Cureus

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Neurofibromatosis type 1 is characterized by multiple cutaneous neurofibromas of varying sizes along with skeletal, neurologic, and ophthalmic features. Solitary swellings in neurofibromatosis type 1 are not commonly encountered except in the form of plexiform neurofibromas. We report two cases with neurofibromatosis type 1 presenting with solitary swelling in the ankles which were proven to be the diffuse type of neurofibroma, radiologically and histopathologically. Diffuse type neurofibroma presenting as ankle swelling in type 1 neurofibromatosis has not been reported before.

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Section: Discussionmentioning

confidence: 99%