A Rapidly Evolving Homeobox at the Site of a Hybrid Sterility Gene

Ting, Chau‐Ti; Tsaur, Shun-Chern; Wu, Mao-Lien; Wu, Chung‐I

doi:10.1126/science.282.5393.1501

Cited by 480 publications

(402 citation statements)

References 21 publications

Supporting

Mentioning

394

Contrasting

Unclassified

Order By: Relevance

“…Of the very few speciation genes identified molecularly, dosage dependent transcription factors are represented (41)(42)(43). Thus, an interesting pursuit in the future would be to explore the possibility that hybrid incompatibility genes represent members of interacting macromolecular complexes that are co-evolving.…”

Section: Could Regulatory Complexes Represent Coevolving Gene Incompamentioning

confidence: 99%

Biological consequences of dosage dependent gene regulatory systems

Birchler

Yao

Chudalayandi

2007

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expres

View full text Add to dashboard Cite

Section: Could Regulatory Complexes Represent Coevolving Gene Incompamentioning

confidence: 99%

Biological consequences of dosage dependent gene regulatory systems

Birchler

Yao

Chudalayandi

2007

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expres

View full text Add to dashboard Cite

“…The OdsH locus in Drosophila, for example, has been shown to be a result of gene duplication followed by positive selection (Ting et al 1998(Ting et al , 2000Sun et al 2004;Wu and Ting 2004). Both the Nup96 gene and the candidate factor Nup153 appear to be products of recent positive selection D.…”

Section: Simulationsmentioning

confidence: 99%

Reinforcement and the Genetics of Hybrid Incompatibilities

Lemmon

Kirkpatrick

2006

Genetics

View full text Add to dashboard Cite

Recent empirical studies suggest that genes involved in speciation are often sex-linked. We derive a general analytic model of reinforcement to study the effects of sex linkage on reinforcement under three forms of selection against hybrids: one-locus, two-locus, and ecological incompatibilities. We show that the pattern of sex linkage can have a large effect on the amount of reinforcement due to hybrid incompatibility. Sex linkage of genes involved in postzygotic isolation generally increases the strength of reinforcement, but only if genes involved in prezygotic isolation are also sex linked. We use exact simulations to test the accuracy of the approximation and find that qualitative predictions made assuming weak selection can hold when selection is strong. Our simulations also show that incompatibilities that evolve in allopatry by drift or weak selection are likely to be lost by swamping during secondary contact, even when selection against hybrids is strong.

show abstract

“…Thus, while many species of abalone might be spewing out gametes, only those sperm and ova that recognize each other biochemically will produce fertile offspring. As determined in Drosophila, 56 a homeobox gene lies at the base of gametic compatibility or incompatibility. Certainly, gametophyte (i.e.…”

Section: Recognizing Speciesmentioning

confidence: 99%

“…39,56 When the latter circumstances directly involving reproduction are not of concern, a question that then arises is: What constrains some members of a species from mating with other individuals with which they could produce reproductively viable offspring?…”

Section: Implications Of a Model Of Evolution Based On Homeobox Genesmentioning

confidence: 99%

Homeobox genes, fossils, and the origin of species

Schwartz

1999

Anat. Rec.

View full text Add to dashboard Cite

Ever since Darwin there has been a history of debate on the tempo and mode of evolution. Is speciation a gradual process involving the accumulation of minute variations extant within a species, or is it rapid, the result of major organismal reorganization? Does one define a species on the basis of genes, morphology, or geographic or reproductive isolation? In this communication I present a model of evolutionary change that is based on the Mendelian inheritance of mutations in regulatory genes and the fact that most nonlethal mutations arise in the recessive state. Since the new recessive allele will spread through many generations without expression until there is a critical mass of heterozygotes capable of producing homozygotes for the mutation, the novel feature thus produced will appear abruptly in the population and in more than one individual. This picture of punctuation is consistent with the fossil record, which typically fails to provide evidence of smoothly transitional states of morphological change. Given that the first of their kind in the fossil record are organisms in which their novel characteristics are often more fully expressed or complex than in their descendants, it would seem that, after the mutation involving a regulatory gene is introduced, the general tendency is for its effects to become diminished. Among the implications for speciation is that this process does not depend on either reproductive isolation or genetic incompatibility. Rather, barring effects on reproductive organs or behavior, homozygotes for a novelty should be able to breed with heterozygotes and homozygotes for the wild state of the original population. This, in turn, suggests that the species barrier between individuals is probably a matter of mate recognition. Anat Rec (New Anat): 257:15-31, 1999.

show abstract

A Rapidly Evolving Homeobox at the Site of a Hybrid Sterility Gene

Cited by 480 publications

References 21 publications

Biological consequences of dosage dependent gene regulatory systems

Biological consequences of dosage dependent gene regulatory systems

Reinforcement and the Genetics of Hybrid Incompatibilities

Homeobox genes, fossils, and the origin of species

Contact Info

Product

Resources

About