A rapid nongenomic effect of aldosterone on intracellular sodium concentration in the distal nephron segment of the rat

Logvinenko, N. S.; Solenov, E. I.; Иванова, Л. Н.

doi:10.1134/s1607672906010030

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Despite low MR mRNA concentrations in pups, locally increased expression of 11β-HSD2 may provide sufficient aldosterone action. Moreover, aldosterone may provide protection from cell volume swelling via non-genomic mechanisms as observed in the pup kidney as well as during lung oedema [51]–[53]. Another possibility is that in pups aldosterone may, at least to some extent, act via GR as suggested [54].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main Adrenocortical Stress Hormone during the Perinatal Period in Rats?

et al. 2013

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Positive developmental impact of low stress-induced glucocorticoid levels in early development has been recognized for a long time, while possible involvement of mineralocorticoids in the stress response during the perinatal period has been neglected. The present study aimed at verifying the hypothesis that balance between stress-induced glucocorticoid and mineralocorticoid levels is changing during postnatal development. Hormone responses to two different stressors (insulin-induced hypoglycaemia and immune challenge induced by bacterial lipopolysaccharid) measured in 10-day-old rats were compared to those in adults. In pups corticosterone responses to both stressors were significantly lower than in adults, which corresponded well with the stress hyporesponsive period. Importantly, stress-induced elevations in aldosterone concentration were significantly higher in pups compared both to corticosterone elevations and to those in adulthood with comparable adrenocorticotropin concentrations in the two age groups. Greater importance of mineralocorticoids compared to glucocorticoids in postnatal period is further supported by changes in gene expression and protein levels of gluco- (GR) and mineralocorticoid receptors (MR) and selected enzymes measured by quantitative PCR and immunohystochemistry in the hypothalamus, hippocampus, prefrontal cortex, liver and kidney. Gene expression of 11beta-hydroxysteroid dehydrogenase 2 (11β-HSD2), an enzyme enabling preferential effects of aldosterone on mineralocorticoid receptors, was higher in 10-day-old pups compared to adult animals. On the contrary, the expression and protein levels of GR, MR and 11β-HSD1 were decreased. Presented results clearly show higher stress-induced release of aldosterone in pups compared to adults and strongly suggest greater importance of mineralocorticoids compared to glucocorticoids in stress during the postnatal period.

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Section: Discussionmentioning

confidence: 99%

Comparison of Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main Adrenocortical Stress Hormone during the Perinatal Period in Rats?

et al. 2013

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“…Both amiloride and RO-31-8220 abolished this effect of aldosterone (p<0.05). Specificity of acute effect of aldosterone was corroborated in the experiments with replacement of aldosterone with corticosterone in a 10-fold concentration, which is known to exhibit no aldosterone-like activity [2]. Thus, PKC inhibitor abolished rapid effect of aldosterone on both the steady-state level of intracellular sodium and on the rate of its changes (Figs.…”

Section: Resultsmentioning

confidence: 69%

“…In principal CCD cells, sodium concentration is mostly determined by dynamic equilibrium between sodium influx from the tubular lumen via epithelial sodium channels and its efflux from the cell into interstitium against gradient with utilization of ATP energy of basolateral sodium pump. We previously showed that during the first 10-15 sec, aldosterone (10 nM) increased intracellular sodium concentration ([Na + ] i ) in principal CCD cells bathed in 14 mM sodium saline not only in mature rats, but also in 10-day pups [2,3]. At this age, aldosterone cannot exert long-term genomic effect on the control of sodium reabsorption [1].…”

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confidence: 99%

Effect of aldosterone on kinetics of intracellular sodium in cortical portion of collecting ducts in rat kidney

2008

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We studied the effect of protein kinase C inhibitor RO-31-8220 (10(-7) M) on rapid nongenomic effect of aldosterone in cells of isolated segment of distal region of collecting duct in rat kidney. Experiments with fluorescent dye Na-Green showed that the inhibitor abolished the modulating effect of aldosterone (10 nM) on intracellular sodium concentration at external sodium concentration of 14 mM. Aldosterone decreased by half the initial rate of the changes in internal sodium concentration in both 10-day and mature rats (p<0.05). Similarly to sodium channel blocker amiloride (10(-5) M), RO-31-8220 abolished rapid nongenomic effect of aldosterone on the rate of the changes in internal sodium concentration.

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Dissociation of adrenocorticotropin and corticosterone as well as aldosterone secretion during stress of hypoglycemia in vasopressin-deficient rats

et al. 2016

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A rapid nongenomic effect of aldosterone on intracellular sodium concentration in the distal nephron segment of the rat

Cited by 4 publications

References 11 publications

Comparison of Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main Adrenocortical Stress Hormone during the Perinatal Period in Rats?

Comparison of Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main Adrenocortical Stress Hormone during the Perinatal Period in Rats?

Effect of aldosterone on kinetics of intracellular sodium in cortical portion of collecting ducts in rat kidney

Dissociation of adrenocorticotropin and corticosterone as well as aldosterone secretion during stress of hypoglycemia in vasopressin-deficient rats

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