Dissociation of adrenocorticotropin and corticosterone as well as aldosterone secretion during stress of hypoglycemia in vasopressin-deficient rats

Várga, J.; Ferenczi, Szilamér; Kovács, Krisztina; Csáno, Ágnes; Prokopova, Barbora; Ježová, Daniela; Zelena, Dóra

doi:10.1016/j.lfs.2016.10.011

Cited by 6 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, during early postnatal development, hypothalamic CRH‐secreting cells are immature. Therefore, the main effector of the stress response is AVP (Varga et al., 2016; Zelena et al., 2008), while hippocampal CRH‐producing cells and receptors are present as early as P1 (Avishai‐Eliner et al., 1996; Chen et al., 2001; Eghbal‐Ahmadi et al., 1998). These ontogenetic differences may account for the differential responses to stress observed here.…”

Section: Discussionmentioning

confidence: 99%

Early life stress induces a transient increase in hippocampal corticotropin‐releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides

Roque

Méndez

Ruiz

et al. 2021

Eur J of Neuroscience

View full text Add to dashboard Cite

Early life stress (ELS) programs hypothalamus‐pituitary‐adrenal (HPA) axis activity and affects synaptic plasticity and cognitive performance in adults; however, the effects of ELS during the temporal window of vulnerability are poorly understood. This study aimed to thoroughly characterize the effects of ELS in the form of periodic maternal separation (MS180) during the time of exposure to stress. Hippocampal corticotropin‐releasing hormone (CRH) gene expression and baseline HPA axis activity were analyzed at postnatal (P) days 6, 12, 15, and 21, and in adulthood (P75); these factors were correlated with plasticity markers and adult behavior. Our results indicate that MS180 induces an increase in hippocampal CRH expression at P9, P12, and P15, whereas an increase in hypothalamic CRH expression was observed from P12 to P21. Increased arginine‐vasopressin expression and corticosterone levels were observed only at P21. Moreover, MS180 caused transient alterations in hypothalamic synaptophysin expression during early life. As adults, MS180 rats showed a passive coping strategy in the forced swimming test, cognitive impairments in the object location test, increased hypothalamic CRH expression, and decreased oxytocin (OXT) expression. Spearman's analysis indicated that cognitive impairments correlated with CRH and OXT expression. In conclusion, our data indicate that MS180 induces a transient increase in hippocampal CRH expression in neonates that precedes the effects on hypothalamic neuropeptides, confirming the role of increased CRH during the temporal window of vulnerability as a mediator of some of the detrimental effects of ELS on brain development and adult behavior.

show abstract

Section: Discussionmentioning

confidence: 99%

Early life stress induces a transient increase in hippocampal corticotropin‐releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides

Roque

Méndez

Ruiz

et al. 2021

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Although increased release of glucocorticoids in response to repeated stressors is a well-known phenomenon [29], The present study shows that repeated exposure to PS leads to a decrease in serum concentrations of the mineralocorticoid hormone aldosterone. This finding is surprising, since other stressors, such as insulin-induced hypoglycaemia, and immune challenge were shown to increase aldosterone concentrations in the rat blood [33,34]. Aldosterone is a somewhat neglected stress hormone and its involvement in stress-related mental disorders is being explored only recently [29].…”

Section: Discussionmentioning

confidence: 99%

Effect of Repeated Predator Scent Exposure on Excitability of Serotonin Neurons and Stress Markers in Rats

Dremencov¹,

Grinchii²,

Buzgoova³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Exposure to predator scent (PS) has been used aa a model of stress associated with danger to life and body integrity. We tested the hypothesis that repeated PS exposure alters the excitability of 5-HT neurons of the dorsal raphe nucleus. To study the mechanisms involved, we approached serum and adrenal corticosterone and aldosterone concentrations, as well as cortical brain-derived neurotrophic factor (BDNF) expression. Adult male Sprague-Dawleys rats were exposed to PS for ten minutes daily for ten consecutive days. Two weeks after the last exposure, the selected electrophysiological and biochemical assessments were performed. Measurements by in vivo electrophysiology showed increased spontaneous firing activity of 5-HT neurons in rats exposed to repeated PS. Repeated PS exposure resulted in reduced serum corticosterone and aldosterone concentrations. Concentrations of both corticosteroids in the adrenal glands, as well as the relative weight of the adrenals, were unaffected. The gene expression of hippocampal BDNF of rats exposed to PS remained unaltered. In conclusion, repeated exposure of rats to PS leads to enhanced firing activity of 5HT neurons accompanied by reduced serum, but not adrenal aldosterone and corticosterone concentrations. Reduced corticosteroid concentrations in the blood appear to be the result of increased metabolism and/or tissue uptake. The decrease in circulating corticosterone in rats experienced repeated PS may represent part of the mechanisms leading to increased excitability of 5-HT neurons. The increase in 5-HT neuronal firing activity might be an important compensatory mechanism designated to diminish the harmful effects of the repeated PS exposure on the brain.

show abstract

“…The subjects of the study were adult (12-14 week old) male Wistar (Toxi-Coop Toxicological Research Center Zrt, Dunakeszi, Hungary) and homozygous Brattleboro rats (+/+ wild type; WT and −/− AVP deficient with diabetes insipidus; DI). The Brattleboro rats were maintained in a colony started from breeder rats from Harlan (Indianapolis, IN), as earlier described (Varga et al 2016). The rats were housed in a controlled environment (23 ± 1 °C, 50-70% humidity, 12 h light starting at 07:00) and had free access to standard rodent chow and tap water, except otherwise indicated.…”

Section: Animalsmentioning

confidence: 99%

Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia

et al. 2020

Self Cite

View full text Add to dashboard Cite

Chronic hypernatremia activates the central osmoregulatory mechanisms and inhibits the function of the hypothalamic-pituitary-adrenal (HPA) axis. Noradrenaline (NE) release into the periventricular anteroventral third ventricle region (AV3V), the supraoptic (SON) and hypothalamic paraventricular nuclei (PVN) from efferents of the caudal ventrolateral (cVLM) and dorsomedial (cDMM) medulla has been shown to be essential for the hypernatremia-evoked responses and for the HPA response to acute restraint. Notably, the medullary NE cell groups highly coexpress prolactin-releasing peptide (PrRP) and nesfatin-1/NUCB2 (nesfatin), therefore, we assumed they contributed to the reactions to chronic hypernatremia. To investigate this, we compared two models: homozygous Brattleboro rats with hereditary diabetes insipidus (DI) and Wistar rats subjected to chronic high salt solution (HS) intake. HS rats had higher plasma osmolality than DI rats. PrRP and nesfatin mRNA levels were higher in both models, in both medullary regions compared to controls. Elevated basal tyrosine hydroxylase (TH) expression and impaired restraint-induced TH, PrRP and nesfatin expression elevations in the cVLM were, however, detected only in HS, but not in DI rats. Simultaneously, only HS rats exhibited classical signs of chronic stress and severely blunted hormonal reactions to acute restraint. Data suggest that HPA axis responsiveness to restraint depends on the type of hypernatremia, and on NE capacity in the cVLM. Additionally, NE and PrRP signalization primarily of medullary origin is increased in the SON, PVN and AV3V in HS rats. This suggests a cooperative action in the adaptation responses and designates the AV3V as a new site for PrRP's action in hypernatremia.

show abstract

Dissociation of adrenocorticotropin and corticosterone as well as aldosterone secretion during stress of hypoglycemia in vasopressin-deficient rats

Cited by 6 publications

References 46 publications

Early life stress induces a transient increase in hippocampal corticotropin‐releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides

Early life stress induces a transient increase in hippocampal corticotropin‐releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides

Effect of Repeated Predator Scent Exposure on Excitability of Serotonin Neurons and Stress Markers in Rats

Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia

Contact Info

Product

Resources

About