A rapid method for sensitive profiling of bioactive triterpene and flavonoid from Astragalus mongholicus and Astragalus membranaceus by ultra-pressure liquid chromatography with tandem mass spectrometry

Liu, Yang; Liu, Jia; Wu, Ke-Xin; Guo, Xiao‐Na; Tang, Zhonghua

doi:10.1016/j.jchromb.2018.03.044

Cited by 45 publications

(30 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…brevicalyx for wound healing [ 14 ] and A. tmoleus for abdominal pain and toothache [ 15 ]. From the light of these ethnobotanical records, several biological and chemical studies were performed on the members of the genus [ 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. In the chemical studies, some biologically-active compounds, including hyperoside, apigenin, kaempferol, and naringenin, were detected [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Polyphenol Profile and Biological Activity Comparisons of Different Parts of Astragalus macrocephalus subsp. finitimus from Turkey

Sarıkürkçü

Zengin

2020

Biology

View full text Add to dashboard Cite

The members of the genus Astragalus have great interest as traditional drugs in several folk systems including Turkey. In this sense, the present paper was aimed to explore the biological properties and chemical profiles of different parts (aerial parts, leaves, flowers, stems, and roots) of A. macrocephalus subsp. finitimus. Antioxidant (radical quenching, reducing power, and metal chelating) and enzyme inhibitory (α-amylase and tyrosinase) effects were investigated for biological properties. Regarding chemical profiles, individual phenolic compounds were detected by LC-MS, as well as total amounts. The leaves extract exhibited the strongest antioxidant abilities when compared with other parts. However, flowers extract had the best metal chelating ability. Hyperoside, apigenin, p-coumaric, and ferulic acids were identified as main compounds in the tested parts. Regarding enzyme inhibitory properties, tyrosinase inhibitory effects varied from IC50: 1.02 to 1.41 mg/mL. In addition, the best amylase inhibition effect was observed by leaves (3.36 mg/mL), followed by aerial parts, roots, stems, and flowers. As a result, from multivariate analysis, the tested parts were classified in three cluster. Summing up the results, it can be concluded that A. macrocephalus subsp. finitimus could be a precious source of natural bioactive agents in pharmaceutical, nutraceutical, and cosmeceutical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Polyphenol Profile and Biological Activity Comparisons of Different Parts of Astragalus macrocephalus subsp. finitimus from Turkey

Sarıkürkçü

Zengin

2020

Biology

View full text Add to dashboard Cite

show abstract

“…Astragalus has been used in TCM for a wide array of therapeutic applications. However, TCM preparations often contain a mixture of different plant materials [42][43] and thus analysis of the individual components can prove difficult. Therefore, it is important to be able to study a single plant species.…”

Section: Discussionmentioning

confidence: 99%

Interactive Antimicrobial Profiles of Astragalus membranaceus (Fisch.) Bunge Extracts and Conventional Antibiotics against Pathogenic and Non-pathogenic Gastrointestinal Bacteria

Lai¹,

Cock²,

Cheesman³

2018

View full text Add to dashboard Cite

Background: The aim of this project was to investigate the efficacy of Astragalus membranaceus (Astragalus) extracts, alone and in combination with conventional antibiotics, against diarrhoea-and dysentery-causing pathogens, as well as against non-pathogenic gastrointestinal bacterial strains. The study sought to validate the chemotherapeutic potential of a traditional Chinese medicinal plant and to identify combinational therapies with increased efficacy compared to either the extracts or conventional antibiotics alone. Methods: Astragalus root powder was extracted with solvents of varying polarity and screened for inhibition of bacterial growth. Susceptibility was assessed by disc diffusion techniques, whilst the minimum inhibitory concentrations (MICs) were quantified by liquid dilution assays. To screen for combinatorial effects, the Astragalus root extracts were combined with a range of conventional antibiotics and tested against each bacterial strain using liquid dilution assays. ΣFIC values were determined and used to determine the class of interaction. Results: Aqueous Astragalus root extracts did not significantly inhibit the growth of the non-pathogenic or beneficial gut microflora bacteria E. cloacae, E. coli or E. faecalis, but possessed mild inhibitory activity against pathogenic A. faecalis, A. hydrophila, B. cereus, S. newport and S. sonnei bacteria. Combinations of the Astragalus extracts and conventional antibiotics generally produced additive or indifferent interactions, indicating that they are safe to use concomitantly without compromising the efficacy of either component. Two cases of antagonistic combinations were detected against B. cereus and S. sonnei. Conclusion: Mild inhibition of 5 pathogenic bacteria occurred with aqueous Astragalus extracts, with a number of additive and antagonistic interactions arising when tested in combination with conventional antibiotics. Astragalus may be used safely in the presence of normal gut bacteria and in most combinations with conventional antibiotics.

show abstract

“…Genus Trifolium (Fabaceae) contains 250 species, most of which have been documented as rich source of formononetin [13]. In addition to this family, formononetin is also present in different plants including Trifolium pratense [14] , Glycine max [15, 16], Sophora flavescens [17], Pycnanthus angolensis [18], Spatholobus suberectus [19], Cicer arietinum [20], Dalbergia odorifera, Pueraria thunbergiana [21], Actaea racemosa [22], Ononis spinosa L. [9], Dalbergia ecastaphyllum [23], Callerya speciosa [24], Astragalus membranaceus [25], and Astragalus mongholicus as shown in Figure 1. The list of plants having Formononetin, their parts, and pharmacological properties are elaborated in Table 1.…”

Section: Natural Sources Of Formononetinmentioning

confidence: 99%

Potential Anticancer Properties and Mechanisms of Action of Formononetin

Jiang

Rasul

Batool

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Nature, a vast reservoir of pharmacologically active molecules, has been most promising source of drug leads for the cure of various pathological conditions. Formononetin is one of the bioactive isoflavones isolated from different plants mainly from Trifolium pratense, Glycine max, Sophora flavescens, Pycnanthus angolensis, and Astragalus membranaceus. Formononetin has been well-documented for its anti-inflammatory, anticancer, and antioxidant properties. Recently anticancer activity of formononetin is widely studied. This review aims to highlight the pharmacological potential of formononetin, thus providing an insight of its status in cancer therapeutics. Formononetin fights progression of cancer via inducing apoptosis, arresting cell cycle, and halting metastasis via targeting various pathways which are generally modulated in several cancers. Although reported data acclaims various biological properties of formononetin, further experimentation on mechanism of its action, medicinal chemistry studies, and preclinical investigations are surely needed to figure out full array of its pharmacological and biological potential.

show abstract

A rapid method for sensitive profiling of bioactive triterpene and flavonoid from Astragalus mongholicus and Astragalus membranaceus by ultra-pressure liquid chromatography with tandem mass spectrometry

Cited by 45 publications

References 30 publications

Polyphenol Profile and Biological Activity Comparisons of Different Parts of Astragalus macrocephalus subsp. finitimus from Turkey

Polyphenol Profile and Biological Activity Comparisons of Different Parts of Astragalus macrocephalus subsp. finitimus from Turkey

Interactive Antimicrobial Profiles of Astragalus membranaceus (Fisch.) Bunge Extracts and Conventional Antibiotics against Pathogenic and Non-pathogenic Gastrointestinal Bacteria

Potential Anticancer Properties and Mechanisms of Action of Formononetin

Contact Info

Product

Resources

About