A rapid Fourier-transform infrared (FTIR) spectroscopic method for direct quantification of paracetamol content in solid pharmaceutical formulations

Mallah, Muhammad Ali; Sherazi, Syed Tufail Hussain; Bhanger, Muhammad Iqbal; Mahesar, Sarfaraz Ahmed; Bajeer, Muhammad Ashraf

doi:10.1016/j.saa.2015.01.036

Cited by 69 publications

(29 citation statements)

References 37 publications

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“…One of the most frequently used drugs is painkillers. Among several painkillers, paracetamol (PC) has commonly been used for fever of viral and bacterial sources and pain relief [3]. PC (acetaminophen, N-acetyl-p-aminophenol) diminishes mild-moderate pain related with headache, migraine, toothache, backache, muscular aches, and postoperative pains [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Enhanced voltammetric detection of paracetamol by using carbon nanotube modified electrode as an electrochemical sensor

Charithra

2019

J. Electrochem. Sci. Eng.

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New aspects associated with electro-catalytic activity of poly(methyl orange) modified carbon nanotube paste electrode (PMMCNTPE) towards the detection of paracetamol (PC) which is typically used worldwide as a pain reliever, were explored through implementation of cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Bare carbon nanotube paste electrode (BCNTPE) was modified by methyl orange using the electropolymerizing method. The effect of pH and influence of potential scan rate were resolved by means of CV technique. It was found that under optimized experimental conditions, PMMCNTPE imparts the analytical curve for PC in the concentration range of 2.0×10-6 – 5.0×10-5 M with detection limit of 3.8×10-8 M and limit of quantification of 1.2×10-8 M. The proposed sensor exhibited acceptable reproducibility, admirable stability, and adequate repeatability. The interference study of PC with dopamine (DA) and folic acid (FA) showed good selectivity of the designed sensor. The feasibility of the constructed electrochemical sensor to detect PC was successfully tested in some pharmaceutical formulations.

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Section: Introductionmentioning

confidence: 99%

Enhanced voltammetric detection of paracetamol by using carbon nanotube modified electrode as an electrochemical sensor

Charithra

2019

J. Electrochem. Sci. Eng.

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“…On the other hand, this method requires high control of humidity and temperature of the working environment. e development of the analytical methods by spectrophotometry in the mid-infrared region has been successfully used in the quanti cation of other drugs [18,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. To develop the proposed method, the rst step was a qualitative test.…”

Section: Discussionmentioning

confidence: 99%

FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin

Fanelli

Zimmermann

Tótoli

et al. 2018

Journal of Chemistry

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Amoxicillin is an antimicrobial agent that belongs to the penicillin compounds. Its bactericidal action causes a destruction of the cell wall of bacteria. It is widely used in clinical practice, and it belongs to the Brazilian National List of Essential Drugs (RENAME). In literature, there are some green analytical methods for the amoxicillin analysis; however, none of them is focused on its quantification in capsules. Therefore, the aim of this study was to validate an environmentally friendly analytical method for the analysis of this antimicrobial action in capsules, using spectrophotometry in the mid-infrared region. The analyses were performed in the spectral range of 1815–1736 cm−1, and the samples were analyzed as potassium bromide pellets. The method was validated according to the ICH guidelines and Brazilian legislation. Linearity, selectivity, precision, accuracy, and robustness were evaluated and showed adequate results for method validation, in a concentration range of 0.5–1.5 mg/pellet. Thus, it is concluded that the validated spectrophotometric method is able to quantify amoxicillin in capsules. In addition, it is a fast, economical, and environmentally friendly method, since it does not use organic solvents, and it can be used for quality control of routine analysis of this drug.

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“…Several analytical methods including GC-MS, HPLC-MS-MS, NMR, Fourier transform infrared (FT-IR) spectroscopy, electronic nose and voltammetric analysis are available for the quality assurance of vegetable oils and fats [3,9]. Over the last 20 years, FT-IR spectroscopy has been widely used in research related to various fields due to substantial improvements in FT-IR spectroscopic instrumentation [10][11][12][13][14]. In the study of edible oils and fats, FT-IR has been recognized as an authoritative analytical tool.…”

Section: Introductionmentioning

confidence: 99%

Detection of lard contamination in five different edible oils by FT-IRspectroscopy using a partial least squares calibration model

Munir¹,

Musharraf²,

Sherazi³

et al. 2019

Turk J Chem

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Lard is defined as animal fat acquired from the adipose tissue of pigs and is not permitted for human consumption or external use by certain religions such as Islam and Judaism. Due to its low-cost availability for commercial use, it is often mixed with other vegetable oils mistakenly or deliberately and causes loss of consumer trust; hence, its detection in food products is essential. Consumers tend to know the authenticity of commercially available edible oils. However, edible oils are subjected to adulteration risks with lard, which breaches consumer rights. In the present study, we designed a transmission Fourier transform infrared spectroscopy (FT-IR)-based method for the rapid detection of lard in sunflower, canola, coconut, olive, and mustard oils. For this purpose, the selected oils were adulterated with lard in different concentration ratios (10:0, 9:1, 7:3, 6:4, 4:6, 3:7, 0:10). A single calibration model was developed for 35 standards (seven standards from each individual five oils) in the frequency range between 1078.01 and 1246.75 cm −1 to determine the relationship between actual adulterant concentration and FT-IR predicted concentrations using a partial least squares (PLS) method. The results of the present study indicated that FT-IR in combination with PLS has the potential to evaluate adulteration of edible oils with lard through single calibration as a rapid, nondestructive, and effective alternative method.

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A rapid Fourier-transform infrared (FTIR) spectroscopic method for direct quantification of paracetamol content in solid pharmaceutical formulations

Cited by 69 publications

References 37 publications

Enhanced voltammetric detection of paracetamol by using carbon nanotube modified electrode as an electrochemical sensor

Enhanced voltammetric detection of paracetamol by using carbon nanotube modified electrode as an electrochemical sensor

FTIR Spectrophotometry as a Green Tool for Quantitative Analysis of Drugs: Practical Application to Amoxicillin

Detection of lard contamination in five different edible oils by FT-IRspectroscopy using a partial least squares calibration model

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