A rapid and controllable acoustothermal microheater using thin film surface acoustic waves

Wang, Yong; Zhang, Qian; Tao, Ran; Chen, Dongyang; Xie, Jin; Torun, Hamdi; Dodd, Linzi E.; Luo, Jingting; Fu, Chen; Vernon, Jethro; Canyelles-Pericas, Pep; Binns, Richard; Fu, Yongqing

doi:10.1016/j.sna.2020.112508

Cited by 32 publications

(26 citation statements)

References 46 publications

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“…Previous SAW-based DNA amplification works [14][15] used crystal based piezoelectric devices (such as LiNbO3), which are brittle and costly. Thin film SAW has also recently been demonstrated as efficient microheaters [52]. Herein this study, we used ZnO/Al sheet SAW devices [51][53].…”

Section: E Saw Device Fabrication and Surface Treatmentmentioning

confidence: 99%

Acousto-Pi: An Opto-Acoustofluidic System Using Surface Acoustic Waves Controlled With Open-Source Electronics for Integrated In-Field Diagnostics

Vernon

Canyelles-Pericas

Torun

et al. 2022

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Surface acoustic wave (SAW) devices are increasingly applied in life science, biology, and point-of-care applications due to their combined acoustofluidic sensing and actuating properties. Despite the advances in this field, there remain significant gaps in interfacing hardware and control strategies to facilitate system integration with high performance and low cost. In this work, we present a versatile, and digitally controlled acoustofluidic platform by demonstrating key functions for biological assays such as droplet transportation and mixing using a closed-loop feedback control with image recognition. Moreover, we integrate optical detection by demonstrating in-situ fluorescence sensing capabilities with a standard camera and digital filters, bypassing the need for expensive and complex optical setups. The Acousto-Pi setup is based on open-source Raspberry Pi hardware and 3D printed housing, and the SAW devices are fabricated with piezoelectric thin film on a metallic substrate. The platform enables the control of droplet position and speed for sample processing (mixing and dilution of samples), as well as the control of temperature based on acousto-heating, offering embedded processing capability. It can be operated remotely while recording the measurements in cloud databases towards integrated in-field diagnostic applications such as disease outbreak control, mass healthcare screening and food safety. Index Terms-Surface acoustic waves, integrated acoustofluidics, open-source electronics, feedback control, pointof-care diagnostics, fluorescence imagining, piezoelectric thin film.

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Section: E Saw Device Fabrication and Surface Treatmentmentioning

confidence: 99%

Acousto-Pi: An Opto-Acoustofluidic System Using Surface Acoustic Waves Controlled With Open-Source Electronics for Integrated In-Field Diagnostics

Vernon

Canyelles-Pericas

Torun

et al. 2022

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

Self Cite

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“… 14 When optimizing dPCR on a chip, thermal non-uniformity is usually not considered as measurement of sample temperature ( T S ) inside partitions with a sample volume of pico-/nano-liters is a challenging job. 15,16 An accurate system to calibrate a temperature sensor with respect to the fluid inside the partitions, and enable determination of the temperature distribution over the dPCR chip, or even between the partitions, would benefit the optimization of temperature uniformity, 17 thus improving PCR efficiency.…”

Section: Introductionmentioning

confidence: 99%

Temperature non-uniformity detection on dPCR chips and temperature sensor calibration

et al. 2022

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“…The latter, on the other hand, involves the use of chip-scale high frequency nanometer amplitude electromechanical excitation in the form of surface acoustic waves (SAWs), whose unprecedented surface vibrational acceleration on the order of 10 million g ’s provides a mechanism for interfacial destabilization 16 that is highly effective for the generation of micron-dimension aerosol droplets 17 , 18 for applications across pulmonary drug delivery 19 , thermal management 20 , water filtration 21 , thin-film deposition 22 , mass spectrometry 23 , 24 , and material synthesis/crystallization 25 , 26 . Additionally, SAWs have been shown to be a powerful vehicle for manipulating microscale fluids for a host of microfluidic applications, such as liquid and drop transport 27 , 28 , tensiometry 29 , mixing 30 , 31 , sorting 32 , heating 33 , greywater treatment 34 , and bubble/particle trapping and manipulation 35 – 38 .…”

Section: Introductionmentioning

confidence: 99%

Nanoscale plasma-activated aerosol generation for in situ surface pathogen disinfection

et al. 2022

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Plasma treatment constitutes an efficient method for chemical-free disinfection. A spray-based system for dispensing plasma-activated aerosols onto surfaces would facilitate disinfection of complex and/or hidden surfaces inaccessible to direct line-of-sight (for example, UV) methods. The complexity and size of current plasma generators (for example, plasma jet and cometary plasma systems)—which prohibit portable operation, together with the short plasma lifetimes, necessitate a miniaturized in situ technique in which a source can be simultaneously activated and administered on-demand onto surfaces. Here, we demonstrate this possibility by combining two nanoscale technologies for plasma and aerosol generation into an integrated device that is sufficiently small and lightweight. Plasma is generated on a carpet of zinc oxide nanorods comprising a nanoneedle ensemble, which when raised to a high electric potential, constitutes a massive point charge array with near-singular electric fields to effect atmospheric breakdown. The plasma is then used to activate water transported through an underlying capillary wick, that is subsequently aerosolized under MHz-order surface acoustic waves. We show that the system, besides being amenable to miniaturization and hence integration into a chipscale device, leads to a considerable improvement in plasma-activation over its macroscale cometary discharge predecessor, with up to 20% and 127% higher hydrogen peroxide and nitrite ion concentrations that are respectively generated in the plasma-activated aerosols. This, in turn, leads to a 67% reduction in the disinfection time to achieve 95% bacterial load reduction, therefore demonstrating the potential of the technology as an efficient portable platform for on-demand field-use surface disinfection.

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A rapid and controllable acoustothermal microheater using thin film surface acoustic waves

Cited by 32 publications

References 46 publications

Acousto-Pi: An Opto-Acoustofluidic System Using Surface Acoustic Waves Controlled With Open-Source Electronics for Integrated In-Field Diagnostics

Acousto-Pi: An Opto-Acoustofluidic System Using Surface Acoustic Waves Controlled With Open-Source Electronics for Integrated In-Field Diagnostics

Temperature non-uniformity detection on dPCR chips and temperature sensor calibration

Nanoscale plasma-activated aerosol generation for in situ surface pathogen disinfection

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