A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) study 22844

Karim, A.B.M.F.; Maat, B.; Hatlevoll, Reidulv; Menten, Johan; Rutten, E.H.J.M.; Thomas, Deborah; Mascarenhas, F.; Horiot, J.C.; Parvinen, L.-M.; Reijn, M. van; Jager, J.J.; Fabrini, Maria Grazia; Alphen, Adriaan M. van; Hamers, Han; Gaspar, Laurie E.; Noordman, E.; Piérart, M.; Glabbeke, M. van

doi:10.1016/s0360-3016(96)00352-5

Cited by 625 publications

(305 citation statements)

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“…For instance, the time to tumour progression after surgery (TTP) is thought to depend on the number of glioma cells infiltrating the resected margin which, in order to form a secondary growth, need to reach a critical cell density (Chicoine and Silbergeld, 1995;Burgess et al, 1997;Silbergeld and Chicoine, 1997). An astrocytic (vs oligodendroglial or mixed) phenotype has been found to be highly predictive of shorter TTP in 379 grade II glioma patients (Karim et al, 1996). Up to four times longer TTP was documented for 1p/19q codeleted Ols than for tumours without these deletions (Fallon et al, 2004).…”

Section: Discussionmentioning

confidence: 98%

“…Patients with grade II and III Ols and OlAs have better prognosis than patients with As of the corresponding grade even in the absence of chemotherapy (Karim et al, 1996;Louis et al, 2001). Similarly, in several studies gliomas with grade IV histology and an oligodendroglial component have been associated with better prognosis than pure GBMs (Donahue et al, 1997;Kraus et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

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Correlation of in vitro infiltration with glioma histological type in organotypic brain slices

et al. 2004

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Diffuse invasion of the brain, an intrinsic property of gliomas, renders these tumours incurable, and is a principal determinant of their spatial and temporal growth. Knowledge of the invasive potential of gliomas is highly desired in order to understand their behaviour in vivo. Comprehensive ex vivo invasion studies including tumours of different histological types and grades are however lacking, mostly because reliable physiological invasion assays have been difficult to establish. Using an organotypic rodent brain slice assay, we evaluated the invasiveness of 42 grade II -IV glioma biopsy specimens, and correlated it with the histological phenotype, the absence or presence of deletions on chromosomes 1p and 19q assessed by fluorescent in situ hybridisation, and proliferation and apoptosis indices assessed by immunocytochemistry. Oligodendroglial tumours with 1p/19q loss were less invasive than astrocytic tumours of similar tumour grade. Correlation analysis of invasiveness cell proliferation and apoptosis further suggested that grade II -III oligodendroglial tumours with 1p/19q loss grow in situ as relatively circumscribed compact masses in contrast to the more infiltrative and more diffuse astrocytomas. Lower invasiveness may be an important characteristic of oligodendroglial tumours, adding to our understanding of their more indolent clinical evolution and responsiveness to therapy.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Correlation of in vitro infiltration with glioma histological type in organotypic brain slices

et al. 2004

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“…To date, results from at least four clinical trials that have enrolled adult patients diagnosed with low-grade glioma have been published. 29,[32][33][34][35][36] None of those trials randomized according to surgical resection; rather, they were randomized according to the use of radiotherapy and/or chemotherapy, although it is interesting to note that, within those trials, one of the primary predictors of outcome was the extent of surgical resection. To our knowledge, no population-based effort exists that has focused exclusively on patients with low-grade gliomas; thus, the commencement of such studies in the near future are likely to generate valuable information regarding outcomes for this group of patients.…”

Section: Discussionmentioning

confidence: 99%

Survival rates in patients with low‐grade glioma after intraoperative magnetic resonance image guidance

Claus

Horlacher

Hsu

et al. 2005

Cancer

430

191

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Background We sought to examine hearing loss in a group from the Royal Australian Air Force who undertook fuel tank maintenance on F‐111 aircraft, with exposure to formulations containing ototoxins, relative to two different comparison groups. Methods Using pure‐tone audiometry, hearing thresholds were assessed in 614 exposed personnel, 513 technical‐trade comparisons (different base, same job), and 403 non‐technical comparisons (same base, different job). We calculated percentage loss of hearing (PLH) and used regression models to examine whether there was an association between PLH and F‐111 fuel tank maintenance, adjusting for possible confounders. In addition, the difference between the observed hearing thresholds and the expected thresholds based on an otologically normal population (ISO‐7029‐2003) was determined. Results The PLH ranged from nil to 96 (median 1.5, quartiles 0.3, 5.5). A logistic regression model showed no statistically significant difference in PLH among the three exposure groups (exposed vs. non‐technical controls 1.1: 95% CI 0.7, 2.0 and exposed vs. technical OR 0.9: 95% CI 0.6, 1.3). The model also highlighted a number of other risk factors for PLH including age, tinnitus, smoking, depression, and use of depression medications. However, at all eight frequencies measured, all populations had lower than expected hearing thresholds based on published ISO‐7029 medians. Conclusions Although there was no difference in PLH between the three exposure groups, the study did reveal a high degree of hearing loss between the 3 groups and a normal population. Am. J. Ind. Med. 53:1159–1169, 2010. © 2010 Wiley‐Liss, Inc.

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“…[5,10,32,34,39,45,59,65] This approach is usually combined with the assessment of conventional measures such as survival duration, time to relapse, and imaging-documented changes in tumor size. [12,13,18,28,35] The toxicity of therapy has also been assessed, for the most part, in categorical terms such as "major" or "minor" morbidity and mortality. [8,9,11] Although a number of investigators have attempted to evaluate cognitive and psychosocial function, [1,23,24,60,66,69,70] relatively few reports of these evaluations appear in current literature.…”

Section: Validity and Quality Of Life Assessment In Neurooncologymentioning

confidence: 99%

Quality of life in patients with brain tumor: what's relevant in our quest for therapeutic efficacy

Bampoe¹,

Ritvo²,

Bernstein³

1998

FOC

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Quality-of-life assessments in neurooncology are becoming more relevant with the proliferation of intensive research into brain tumors and their therapy. In this review, the authors examined several aspects and problems associated with the past, present, and future applications of quality-of-life assessments in neurooncology. The inadequacy of the almost exclusive use of physical functioning assessments, image-documented tumor response to therapy, and patient survival time as endpoints when evaluating therapeutic regimens is becoming increasingly apparent. In therapies in which outcome using traditional endpoints are only marginally different, specific (neurological) toxicity and social and psychological outcomes must be evaluated as well to determine valid treatment options. Also becoming widely accepted is the consideration of patient values of specific health states in justifying treatment resources. There is ongoing research in brain tumor patients to address these issues.

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A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) study 22844

Abstract: is G a spa r , M.D.,n E va N o o r d m a n , M.D., P h .D .* M a r ia n n e P ier a r t, M.Sc/1 a n d M a r t in e v a n G l a b b e k e , M.

Cited by 625 publications

References 11 publications

Correlation of in vitro infiltration with glioma histological type in organotypic brain slices

Correlation of in vitro infiltration with glioma histological type in organotypic brain slices

Survival rates in patients with low‐grade glioma after intraoperative magnetic resonance image guidance

Quality of life in patients with brain tumor: what's relevant in our quest for therapeutic efficacy

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