Quality of life in patients with brain tumor: what's relevant in our quest for therapeutic efficacy

Abstract

<jats:p>Quality-of-life assessments in neurooncology are becoming more relevant with the proliferation of intensive research into brain tumors and their therapy. In this review, the authors examined several aspects and problems associated with the past, present, and future applications of quality-of-life assessments in neurooncology.</jats:p> <jats:p>The inadequacy of the almost exclusive use of physical functioning assessments, image-documented tumor response to therapy, and patient survival time as endpoints when evaluating therapeutic regimens is becoming increasingly apparent. In therapies in which outcome using traditional endpoints are only marginally different, specific (neurological) toxicity and social and psychological outcomes must be evaluated as well to determine valid treatment options. Also becoming widely accepted is the consideration of patient values of specific health states in justifying treatment resources. There is ongoing research in brain tumor patients to address these issues.</jats:p>

Interest and nature of the psychological care for patients and close relations in a medical dedicated neuro-oncology unit

“…Elle repose sur la prise en charge [1] diagnostique et théra-peutique des tumeurs primitives ou secondaires du système nerveux et de ses enveloppes [2], des complications neurologiques des malades suivis pour un cancer et [3] des pathologies neuro-oncogénétiques (neurofibromatose de type 1, maladie de Von Hippel Lindau…) prédisposant à la survenue de tumeurs du système nerveux.…”

“…Cette période des soins implique, en sus des impératifs oncologiques, la nécessaire prise en charge des symptômes liés à la maladie et aux traitements au même plan que celle de la maladie tumorale dans un état d'esprit où la « qualité de vie » ne peut aucunement être dissociée de la survie [2,18].…”

Parameters of life quality in the treatment efficiency estimation of patients with glial brain tumors

“…Пîíяòèå ÊЖ ïðèìåíèòåëüíî ê ìåäèöèíå èñïîëüзóюò â íàóчíîé ëèòåðàòóðå, íàчèíàя ñ 1977 ã. Пî äàííыì êîíôåðåíöèè Нàöèîíàëüíîãî Иíñòèòóòà Рàêà ÑША (NCI) è Аìåðèêàíñêîãî Îбщåñòâà Êëèíèчåñêîé Îíêîëîãèè (ASCO), êîòîðàя ñîñòîяëàñü â 1990 ã., ïîêàзàòåëü ÊЖ яâëяåòñя âåäóщèì ïî зíàчèìîñòè êðèòåðèåì îöåíêè ðåзóëüòàòîâ ïðîòèâîîïóхîëåâîãî ëåчåíèя ïîñëå ïîêàзàòåëя âыaeèâàåìîñòè [3,5,12,13].…”

“…Тàêaeå â ëèòåðàòóðå шèðîêî ðàñïðîñòðàíåí òåðìèí «êàчåñòâî aeèзíè, ñâязàííîå ñî зäîðîâüåì», чòî ïîзâîëяåò äèôôåðåíöèðîâàííî îïðåäåëяòü âëèяíèå бîëåзíè íà ëåчåíèå è ñîñòîяíèå ïàöèåíòà [9]. Тàêèì îбðàзîì, эôôåêòèâíîñòü ëåчåбíых è ðåàбèëèòàöèîííых ìåðîïðèяòèé ñîïîñòàâëяюò ñ ñóбъåêòèâíыì ìíåíèåì ñàìîãî ïàöèåíòà, чòî äàåò âîзìîaeíîñòü îïðåäåëèòü íå òîëüêî åãî îбъåêòèâíыé ñòàòóñ, íî è ñàìîîöåíêó эòîãî ñòàòóñà [13].…”

“…Îñîбóю âàaeíîñòü èзóчåíèå эòèх âîïðîñîâ ïðèîбðåòàåò â íåéðîîíêîëîãèè ó бîëüíых ñ ÃÃМ, ïîñêîëüêó, íàðяäó ñ îбåñïåчåíèåì êàчåñòâà è äîñòóïíîñòè âыñîêîêâàëèôèöèðîâàííîé ìåäèöèíñêîé ïîìîщè, íåîбхîäèìî èìåòü â âèäó òàêèå aeèзíåííыå àñïåêòы, êàê òðóäíîñòè ñîöèàëüíîé àäàïòàöèè â èзìåíяющåìñя ìèðå, îщóщåíèå ïàöèåíòîì бåñïåðñïåêòèâíîñòè è бåзыñхîäíîñòè ñâîåãî ñîñòîяíèя, îбóñëîâëåííîãî îíêî-ëîãèчåñêèì зàбîëåâàíèåì, óòðàòîé äååñïîñîбíîñòè è èíâàëèäèзàöèåé âñëåäñòâèå íàðóшåíèя ôóíêöèé îðãàíèзìà, ïîяâëåíèåì ïîбîчíых ðåàêöèé íà ïîñòîяííî ïðèìåíяåìыå ëåêàðñòâåííыå ñðåäñòâà, â ïåðâóю îчåðåäü, àíòèбëàñòèчåñêèå ïðåïàðàòы, зàâèñèìîñòüю îò íåîбхîäèìîñòè ïîñòîðîííåé ïîìîщè è äð. [13,17,21,22,24,25].…”