A randomized trial of adjuvant chemotherapy after radical hysterectomy in stage Ib-IIa cervical cancer patients with pelvic lymph node metastases☆

Tattersall, Martin H. N.; Ramirez, Corazon; Coppleson, Malcolm

doi:10.1016/0090-8258(92)90251-d

Cited by 79 publications

(44 citation statements)

References 15 publications

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“…The trial comparing adjuvant chemotherapy followed by radio-therapy versus radiotherapy alone (Tattersall 1992) found little difference in outcomes between the two treatment groups (Summary of findings 2); it should be noted that in this trial chemotherapy was given sequentially and not in combination with radiotherapy.…”

Section: Summary Of Main Resultsmentioning

confidence: 80%

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Adjuvant platinum-based chemotherapy for early stage cervical cancer

Falcetta

Medeiros

Edelweiss

et al. 2016

Cochrane Database of Systematic Reviews

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Section: Summary Of Main Resultsmentioning

confidence: 80%

“…Concealment of allocation was adequate in one study (Tattersall 1992) but was not described in two studies (Peters 2000; Protocol CE3005).…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

Adjuvant platinum-based chemotherapy for early stage cervical cancer

Falcetta

Medeiros

Edelweiss

et al. 2016

Cochrane Database of Systematic Reviews

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“…Intra-pelvic recurrences were higher for the chemotherapy group than for the radiotherapy group (85% and 38%, respectively), whereas extra-pelvic recurrences were noted in 23% of the chemotherapy group but 71% of the radiotherapy group 38) . Some investigators have suggested that adjuvant chemotherapy increases the survival rate of high-risk patients, although a randomized trial showed no clear consensus 39) . In the majority of the cases we investigated , patients who received adjuvant chemotherapy after the operation had been treated with CPT-11 and CDDP.…”

Section: Resultsmentioning

confidence: 99%

Retrospective Investigation of Patients with Cervical Cancer and its Prognostic Factors

et al. 2005

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Background : The purpose of this study were to investigate the survival rate of patients with cervical cancer who were treated at our institution and to analyse its prognostic factors. Methods : One hundred twenty-two patients who underwent treatment for primary cervical cancer at Kochi Municipal Hospital between January 1996 and August 2003 (7 years 8 months) were retrospectively reviewed. There were 59 patients (48.4%) with stage 0 disease. Sixty-three patients (51.6%) had stage I-IV cervical cancer. The mean age was 56.7±15.6 years, and the median follow-up period was 31 months. Results : The overall 5-year suvival rate was 96.4% and 77.1% in stage I and II, respectively. The overall 3-year survival rate was 56.3% in stage III, and the 30-month survival rate was 0% in stage IV. Among the risk factors of histologic cell type, clinical parametrial involvement, clinical vaginal involvement and pelvic lymph node metastasis , clinical parametrial involvement had the lowest p value (p=0.0717) in a multivariate Cox proportional hazards regression analysis.Multivariate analysis using the Cox proportional hazard regression model showed that among the risk factors of histologic cell type, clinical parametrial involvement, clinical vaginal involvement and pelvic lymph mode metastasts, the lowest p value (p=0.0717) was for clinical parametrial involvement. Conclusion : Although there was no statistical significance comparing the prognostic factors in multivariate analysis, it was presumed that clinical parametrial involvement was the most influential factor among those which were analyzed in this study on the prognosis of patients with stage I-IV cervical cancer.Key words : cervical cancer, prognosis, prognostic factors Cervical cancer is second only to breast cancer as the most common female malignancy in both incidence and mortality worldwide 1)

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“…Ținând cont de toate acestea, o serie de autori au propus asocierea la radioterapia efectuată în postoperator și a chimioterapiei concomitente [11,12].…”

Section: Histerectomia Radicală Urmată De Radio-și Eventual Chimioterunclassified

Modalități Diverse de Tratament în Cancerul de Col Uterin Clinic Evident (Stadiile I B și II A)

2014

J de Chirurgie

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This paper aims to update certain aspects of the therapeutic attitude on cervical cancer, a disease that currently is, worldwide, the second leading cause of cancer death in women and thus has increasingly come to the attention of general surgeons. The obvious clinical forms of cervical cancer are brought into discussion, meaning those in the FIGO IB1, IB2 and IIA stages, these being, by far, the most numerous cases we meet in the clinic. Unlike early cervical neoplastic lesions (stages 0 and IA) where the therapeutic attitude is relatively well codified and uniform, in obvious clinical forms there is a great variability of therapeutic approaches, with results that are close to those from the studied literature, indicating according to various statistics a survival rate at 5 years of 80% and 90% for stage I disease and between 60% and 80% for stage II patients.Keywords: Cervical Uterin Cancer; Radical Hysterectomy; Radiotherapy; Chemotherapy IntroducereCancerul de col uterin continuă să reprezinte o problemă de sănătate, peste tot în lume fiind a doua mare cauza de deces prin cancer în rândul femeilor cu peste 500.000 de cazuri noi diagnosticate anual și cu o rată a mortalității de aproximativ 50% [1]. Dintre cazurile noi diagnosticate, aproximativ 79% apar în țările în curs de dezvoltare în timp ce în Statele Unite, cancerul de col uterin este a șasea leziune malignă, ca frecvență, în rândul femeilor cu 12.900 noi cazuri diagnosticate pe an și cu aproximativ 4.400 decese anual [1].Aceste discrepanțe se explică prin diferențele privind implementarea programelor de prevenție a cancerului de col uterin, mult mai ferme în țările dezvoltate.În aceste țări, citologia cervicală reprezintă un foarte bun instrument de screening pentru leziunile pre-invazive, pe când în țările în curs de dezvoltare cele mai multe femei sunt diagnosticate cu forme invazive cu simptomatologie asociată și, în consecință, cu un prognostic mai rezervat [2]. Tratamentul cancerului de col uterin clinic evidentSpre deosebire de leziunile cervicale incipiente (stadiile 0 și IA) unde atitudinea terapeutică este relativ bine codificată și unitară, în formele clinic evidente (stadiile IB și IIA) există o mare variabilitate de abordare terapeutică, cu rezultate foarte apropiate așa cum reiese și din studiile analizate.Atât chirurgia cât și radioterapia pot fi utilizate ca primă modalitate terapeutică a cancerului de col uterin în stadiile IA și IIA, cu rezultate aparent asemănătoare.Astfel, Landoni și colab. au analizat, într-un studiu randomizat, rezultatele chirurgiei radicale versus radioterapie în stadiile IB și IIA ale cancerului cervical, negăsind diferențe semnificative nici în ceea ce privește intervalul liber de boală și nici în ceea ce privește supraviețuirea la distanță. Totuși, la 84% dintre pacientele cu tumori cervicale mari (> 4 cm), supuse intervenției chirurgicale radicale ca prim timp, li s-a efectuat radioterapie adjuvantă în condițiile existenței unor factori de risc adiționali [3]. Este recunoscut faptul că, în cazul tumo...

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A randomized trial of adjuvant chemotherapy after radical hysterectomy in stage Ib-IIa cervical cancer patients with pelvic lymph node metastases☆

Cited by 79 publications

References 15 publications

Adjuvant platinum-based chemotherapy for early stage cervical cancer

Adjuvant platinum-based chemotherapy for early stage cervical cancer

Retrospective Investigation of Patients with Cervical Cancer and its Prognostic Factors

Modalități Diverse de Tratament în Cancerul de Col Uterin Clinic Evident (Stadiile I B și II A)

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