A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations

Quinn, James V.

doi:10.1001/jama.277.19.1527

Cited by 103 publications

(81 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Randomized trials comparing octylcyanoacrylates with sutures for facial laceration repair, found no difference in cosmesis as evaluated by plastic surgeons blinded as to whether skin adhesive was used [4, 6]. Our experience confirms that skin adhesives produce good cosmetic results.…”

Section: Resultssupporting

confidence: 61%

See 1 more Smart Citation

A Prospective Analysis of the Use of Octylcyanoacrylate Tissue Adhesive for Wound Closure in Pediatric Neurosurgery

et al. 1999

View full text Add to dashboard Cite

Objective: Cyanoacrylate monomers have been developed for use as skin adhesives. Previous studies have demonstrated that using this skin adhesive for the closure of traumatic lacerations results in excellent cosmesis, decreased procedure-related pain and timesavings. Surgical Technique: Octylcyanoacrylate skin adhesive is applied after the placement of deep fascial sutures with close approximation of the skin edges. The adhesive is applied in liquid form and polymerizes rapidly to solid form. Multiple layers are applied forming a hard impenetrable barrier. Results: This technique was prospectively evaluated in the closure of 102 elective neurosurgical operations with 142 incisions: ventriculoperitoneal shunt insertion/revision (53%) and craniotomy for tumors (10%) were the commonest procedures. There were a total of 83 scalp, 36 abdominal, 8 neck, 6 chest and 6 lumbar incisions. The mean incision length was 5.1 cm (range 0.25–50 cm). Fifty-nine percent of the wounds had previous areas of operative incisions. Complications included 1 poor cosmetic result and 4 cerebrospinal fluid (CSF) leaks. Of the 4 patients with CSF leaks, 2 required operative wound revision, and 1 required ventriculoperitoneal shunting for hydrocephalus. Conclusion: Cyanoacrylate skin adhesive is a viable means of obtaining cosmetic wound closure. Its use requires attention to proper skin approximation and hemostasis. In our experience, propensity for CSF leakage especially in reoperative procedures is a relative contraindication.

show abstract

Section: Resultssupporting

confidence: 61%

“…Several studies have examined the use of octylcyanoacrylate tissue adhesives and found them to be useful for the closure of traumatic lacerations and surgical incisions [2, 3, 4]. Advantages of this technique over traditional suture technique include a needleless wound repair and reduced procedure-related pain.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Analysis of the Use of Octylcyanoacrylate Tissue Adhesive for Wound Closure in Pediatric Neurosurgery

et al. 1999

View full text Add to dashboard Cite

show abstract

“…It is the first cyanoacrylate adhesive to pass all ISO (International Standards Organization) standards and has been classified as a nontoxic medical device, thus its designation as a medical-grade adhesive [7]. A paint-on formulation of this cyanoacrylate has been approved by the Food and Drug Administration (FDA) for external use as a topical wound closure device [8]. This nontoxic adhesive has been placed in a pump spray bottle so that it can be sprayed on forming a thin topical bandage.…”

Section: Introductionmentioning

confidence: 99%

The Effect of a New Tissue-Adhesive Wound Dressing on the Healing of Traumatic Abrasions

Quinn¹,

Lowe

Mertz³

2000

Dermatology

View full text Add to dashboard Cite

Background: Octylcyanoacrylate is a new medical-grade adhesive with antimicrobial properties. It forms a thin, flexible, occlusive bandage. Objective: To determine the gross and histological effects of the spray bandage when treating abrasions. Methods: Abrasions were produced on the flanks of 18 albino guinea pigs and randomized to treatment with a control (Biobrane) or octylcyanoacrylate dressing. The wounds were assessed with digital photography using a previously validated method. Histopathological analysis was done on day 14. Results: There were no differences in the mean wound-healing ratios on days 1 (1.25 vs. 1.23, p = 0.61), 7 (1.15 vs. 1.13, p = 0.14) and 14 (1.03 vs. 1.02, p = 0.63) for tissue adhesive and Biobrane, respectively. There were no differences found on histopathological analysis either. Conclusions: This external spray bandage was well tolerated and did not show any signs of histotoxicity or adverse wound healing.

show abstract

“…The advantages of cyanoacrylates, which have been documented in several published reports, include time saving, omitting the need for suture removal and cost effectiveness [1,7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the long-term outcome of wounds closed with ”Indermil" adhesive

Jaibaji¹,

Liddington

Geary

et al. 2000

European Journal of Plastic Surgery

View full text Add to dashboard Cite

Indermil" is a new formulation of n-Butyl-2-Cyanoacrylate used for securing skin grafts and surface wound closure. We report a prospective randomized trial, comparing the use of "Indermil" adhesive with suture in wound closure. A total of 30 patients underwent 37 procedures for the removal of benign skin lesions under local anaesthesia. "Indermil" was used in the skin closure in 18 procedures and sutures were used in 19 procedures. Scar quality, patient satisfaction and complications were recorded at a period between 8 and 18 months (median 12.2) following the procedure. The study showed no difference between the two groups in terms of scar quality and patient satisfaction. We conclude that long term outcome of wounds closed with "Indermil" are no different from sutured wounds.

show abstract

A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations

Cited by 103 publications

References 0 publications

A Prospective Analysis of the Use of Octylcyanoacrylate Tissue Adhesive for Wound Closure in Pediatric Neurosurgery

A Prospective Analysis of the Use of Octylcyanoacrylate Tissue Adhesive for Wound Closure in Pediatric Neurosurgery

The Effect of a New Tissue-Adhesive Wound Dressing on the Healing of Traumatic Abrasions

Evaluation of the long-term outcome of wounds closed with ”Indermil" adhesive

Contact Info

Product

Resources

About