The Effect of a New Tissue-Adhesive Wound Dressing on the Healing of Traumatic Abrasions

Quinn, James L.; Lowe, Laurie; Mertz, M.

doi:10.1159/000051550

Cited by 27 publications

(18 citation statements)

References 6 publications

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“…[10][11][12] Quinn et al found that superficial abrasions in guinea pigs treated with an OCA spray healed as well as those treated with Biobrane. 13 Singer et al reported similar results after treating deep, partial-thickness excisional wounds with OCA in a porcine model. 14 Davis et al found that small, superficial, partialthickness porcine wounds treated with a slightly different and weaker version of a liquid OCA healed faster than those treated with a hydrocolloid dressing.…”

mentioning

confidence: 73%

Octylcyanoacrylate for the Treatment of Small, Superficial, Partial-thickness Burns: A Pilot Study

Singer

Soroff

Brebbia

2005

Academic Emergency Medicine

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Background: Octylcyanoacrylate (OCA) is a tissue adhesive used to close wounds and to treat minor abrasions. Objective: To explore the use of OCA in patients with superficial, partial-thickness burns. Methods: A prospective, noncomparative, pilot study was conducted in an emergency department (ED) and burn center. Consecutive patients with early (,6 hours), small (,5% total body surface area [TBSA]), superficial, partial-thickness burns were enrolled. Burns were cleaned and any nonadherent necrotic epidermis was removed. Tense blisters were aseptically aspirated. Burns were then covered with a liquid OCA that was applied with a sponge brush. Pain of cleansing and OCA application was recorded, and physicians assessed ease of application. Burns were evaluated every one to two days until complete epithelialization for the presence of infection and exudation, and the OCA was reapplied as necessary. Main outcomes measured were the need for additional topical therapy, pain and ease of application, patient comfort, and satisfaction. Results: Ten patients were enrolled. Mean patient age (6 standard deviation [SD]) was 23 (616) years, four were female, and nine were white. Burns were located on the hands (5),

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mentioning

confidence: 73%

Octylcyanoacrylate for the Treatment of Small, Superficial, Partial-thickness Burns: A Pilot Study

Singer

Soroff

Brebbia

2005

Academic Emergency Medicine

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“…Each wound was 10 mm in length and 5~7 mm in depth. The formulated 0.1% papain immobilized in 6% pectin gel was sprayed on wounds using pump-spray method [16], enough to form a thin film. The lineal size of each wound was recorded.…”

Section: Bî~äì~íáçå=çñ=íüé=bññáå~åó=çñ=rëáåö=cçêãìä~íéç= = M~é~áåjééåmentioning

confidence: 99%

A new formulated stable papin-pectin aerosol spray for skin wound healing

Jáuregui

Cabrera

Ceniceros

et al. 2009

Biotechnol Bioproc E

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^Äëíê~Åí= A new spray-on topical wound debrider composition consisting of 0.1% w/v papain immobilized in 6% w/v pectin gel was formulated for skin wound healing. The stability of the enzyme activity of this new formulated spray was compared with the 0.1% w/v papain in water solution at the refrigerated temperature of 4 and 75°C. Two aerosol propellants, air and nitrogen, were evaluated for their efficacy. The new formulated spray was then evaluated for its thermal stability under air and N 2 at 75°C. All enzyme activity of papain was measured with a spectrophotometer using casein as a substrate at 37°C and in 0.1 M phosphate buffer at pH 6, as well as trichloral acetic acid to separate the product of casein hydrolysis. All the evaluations showed the new aerosol spray formulation to be far better than the liquid formulation in storage stability and thermal stability at 75°C under atmospheric or higher pressures. The new formulation was tested in a rabbit experiment to evaluate the effectiveness of wound healing. As compared to untreated wound, the formulated spray clearly was superior, yielding a 20% more healing progress in the first 4 days alone. © KSBB hÉóïçêÇëW=é~é~áå=ëí~ÄáäáíóI=éÉÅíáå=ÖÉäI=éêçéÉää~åí=éêÉëëìêÉ=ÉÑÑÉÅí

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“…43 While our results suggest that exposure of debrided burns to OCA may delay reepithelialization, a study of abraded guinea pig wounds failed to note any delays in reepithelialization of OCA-treated wounds. 44 …”

Section: 21mentioning

confidence: 99%

The Effects of Epidermal Debridement of Partial‐thickness Burns on Infection and Reepithelialization in Swine

Singer

Thode

McClain

2000

Academic Emergency Medicine

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Abstract. Objective: Early postburn debridement of burn blisters is controversial. This study was conducted to compare rates of infection and reepithelialization in debrided vs nondebrided second-degree burns in swine. Methods: This was a prospective, blinded, controlled, experimental trial using isoflurane-anesthetized swine. Standardized partial-thickness burns were inflicted by applying an aluminum bar preheated to 80ЊC to the backs and flanks of two young pigs for 20 seconds. In half of the burns the necrotic epidermis was manually debrided. All burns were randomly treated with octylcyanoacrylate spray (OCA) or dry gauze (C). Full-thickness biopsies were taken at 7, 10, and 14 days for blinded histopathologic evaluation. The primary outcomes were the proportions of infected burns at days 7 and 10 and the proportion of completely reepithelialized burns at day 14. Burns were considered infected in the presence of intradermal neutrophils containing bacteria (intraobserver agreement, = 1.00). A secondary outcome was the proportion of burns with the presence of scar tissue (abnormal collagen under polarized light; intraobserver correlation, = 0.93). Chi-square tests were used for group comparisons. This study had 90% power to detect a 40-percentage-point difference in infection rates (␣ = 0.05). Results: A total of 126 biopsies from 42 burns were available for review. Infection rates were higher in the debrided burns both at day 7 (55% vs 4.5%, p < 0.001) and at day 10 (65% vs 9%, p < 0.001) after injury. The proportion of nondebrided burns that were completely reepithelialized was higher at days 10 (68% vs 0%, p < 0.001) and 14 (100% vs 65%, p = 0.003). The presence of scar tissue was more common in debrided burns (75% vs 4.5%, p < 0.001). Burns treated with OCA had fewer infections than controls (4% vs 55%, p < 0.001). Fewer OCA-treated debrided burns were reepithelialized at 14 days than those that were not debrided (30% vs 100%, p = 0.001). Conclusions: Under the current study conditions, early postburn epidermal debridement of second-degree burns resulted in more infections and slower reepithelialization rates in swine. The effects of early postburn epidermal debridement in humans should be explored.

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The Effect of a New Tissue-Adhesive Wound Dressing on the Healing of Traumatic Abrasions

Cited by 27 publications

References 6 publications

Octylcyanoacrylate for the Treatment of Small, Superficial, Partial-thickness Burns: A Pilot Study

Octylcyanoacrylate for the Treatment of Small, Superficial, Partial-thickness Burns: A Pilot Study

A new formulated stable papin-pectin aerosol spray for skin wound healing

The Effects of Epidermal Debridement of Partial‐thickness Burns on Infection and Reepithelialization in Swine

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