A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles

Narins, Rhoda S.; Baumann, Leslie; Brandt, Fredric S; Fagien, Steven; Glazer, Scott D.; Lowe, Nicholas J.; Monheit, Gary D.; Rendon, Marta; Rohrich, Rod J.; Werschler, William Philip

doi:10.1016/j.jaad.2009.07.040

Cited by 77 publications

(92 citation statements)

References 37 publications

(55 reference statements)

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“…Since the patients described above were treated, a clinical trial in which subjects were treated with injectable PLLA or human collagen (CosmoPlast, Allergan-Inamed, USA) at three-week intervals has been completed (40). In this study, there were three weeks between treatments; a mean of 3.2 injection sessions were required by subjects in the injectable PLLA group.…”

Section: Discussionmentioning

confidence: 99%

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Optimizing injectable poly-L-lactic acid administration for soft tissue augmentation: The rationale for three treatment sessions

Bauer¹,

Graivier²

2011

J Plast Surg

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Section: Discussionmentioning

confidence: 99%

“…The recent approval of injectable PLLA in the United States for use in immunocompetent individuals (18) allows its use for aesthetic purposes in a wider range of patients. This approval was based on a single study of injectable PLLA (40), which is discussed later in the present article.…”

Section: Methodsmentioning

confidence: 99%

Optimizing injectable poly-L-lactic acid administration for soft tissue augmentation: The rationale for three treatment sessions

Bauer¹,

Graivier²

2011

J Plast Surg

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“…A 6-month comparison study examined the efficacy and safety profiles of plain CaHA and CaHA mixed with lidocaine for the treatment of nasolabial folds. [68] In this study, 16 patients with moderate-to-deep wrinkle ratings were recruited. A visual analog pain scale was used to assess the patients' pain perception.…”

Section: Other Fillersmentioning

confidence: 99%

“…Both of the groups reported satisfaction with the treatment and much less pain when CaHA was mixed with lidocaine as compared to plain CaHA. [68] Intradermal fillers have also been used with other anti-aging chemicals including BOTOX®. A study by Coleman and Carruthers [69] showed that in younger subjects with glabellar frown lines, treatment with BOTOX®-alone did not show positive results, but when combined with intradermal fillers such as HA gave an immediate resting result and made it last twice as long.…”

Section: Other Fillersmentioning

confidence: 99%

Intradermal fillers for minimally invasive treatment of facial aging

Lin¹,

Shah²,

Dhinakar³

et al. 2016

PAR

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The ever-increasing interest in retaining a youthful physical appearance has facilitated the development of various minimally invasive dermatological techniques. The use of intradermal fillers can be incorporated into dermatological practices with minimal overhead costs. This strategy addresses facial volume loss and dynamic lines, which are the main features of facial aging. Moreover, intradermal fillers provide an array of flexible treatment options for a balanced and holistic result to dermatological practitioners. This paper reviews the different intradermal fillers categorized by biodegradable and non-permanent fillers including collagen based materials, hyaluronic acid and autologous fat, semi-permanent fillers including poly methyl methacrylate, poly-L-lactic acid and calcium hydroxyapatite microspheres, and permanent fillers including silicone. A discussion is provided of the commercial products made of these materials and their clinical efficacy in the treatment of facial aging. Key words:Intradermal fillers; facial aging; volumization; biodegradable and non-permanent fillers; semipermanent fillers; permanent fillers Xin Zhao is an associate professor at Xi'an Jiaotong University, China. Prior to starting this appointment, she was a postdoctoral fellow at Medical School and School of Engineering and Applied Sciences at Harvard University. Her research involves engineering the micro-and nanoscale systems for tissue regeneration and drug delivery.

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“…In 22 patients, palpable but non-visible subcutaneous micronodules were observed Not specified/not known [101] Prospective study (n = 116), 25 months follow-up Only 1 case of injection site bruising Treatment related [102] Prospective study (n = 10), 36 months follow-up Short-term complications Not specified/not known [34] Prospective study (n = 65), 36 months follow-up…”

Section: {{mentioning

confidence: 99%

Clinical data on injectable tissue fillers: a review

Vries

Geertsma

2013

Expert Review of Medical Devices

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Treatment with injectable tissue fillers for aesthetic purposes is increasingly popular. In parallel with this success, questions related to the safety of these treatments and the products involved are being raised more prominently. To gain insight in the safety aspects of injectable tissue fillers, we performed a literature review to collect studies reporting clinical data of injectable tissue fillers. We found several case reports where serious complications after more than three years are described. However, there are only a limited number of well-defined prospective clinical studies available with follow-up periods longer than three years. Furthermore, causes of complications, that is, treatment or product related, are often not specified in literature. Considering the intended functional period of fillers in combination with the known occurrence of long-term complications, there is a need for well-defined prospective clinical studies. In order to be able to discriminate between product failure (a product safety issue) or application methodology (a physician expertise or training issue), better identification of observed complications and whether they are product or treatment related, is needed. For the safe use of the fillers it is important that treatment with injectable tissue fillers is performed by a trained physician, who knows the product specifications and its applications. . Moreover, it is expected that due to increase in life expectancy, the demand for anti-aging treatments, like tissue augmentation with injectable tissue fillers, will grow [2]. Their success has been attributed to the fact that treatments with injectable tissue fillers are fast and appear to be relatively easy [2]. Only a relatively 'simple' subcutaneous injection is needed. Today, various injectable tissue fillers with different characteristics are available, for example, duration of the effect, material type and intended anatomical location.Although the application of an injectable tissue filler seems to be relatively simple and safe, reports of serious adverse effects have appeared in the literature [2][3][4][5][6][7][8]. Estimates of the occurrence of severe complications after treatment with various types of injectable tissue fillers range between 1:80 and 1:50,000 patients [9,10]. Adverse side effects can be caused by incorrect injection techniques (treatment related) or by the characteristics of the products (product related) [11,12]. Short-, mid-and long-term complications can be discerned (TABLE 1) [2,13-15]. Short-term complications like pain, swelling, fever, immediate hypersensitivity reactions, occur immediately or within several days past treatment and disappear after several weeks. A more severe short-term complication is necrosis [5,16]. Necrosis occurs immediately or within a few days if blood vessels are obstructed by the filler material or if they are injured during the treatment [17]. Mid-term complications such as delayed inflammatory reactions, ulceration and granuloma reaction may occur after 2-12 months. I...

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A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles

Cited by 77 publications

References 37 publications

Optimizing injectable poly-L-lactic acid administration for soft tissue augmentation: The rationale for three treatment sessions

Optimizing injectable poly-L-lactic acid administration for soft tissue augmentation: The rationale for three treatment sessions

Intradermal fillers for minimally invasive treatment of facial aging

Clinical data on injectable tissue fillers: a review

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