Optimizing injectable poly-L-lactic acid administration for soft tissue augmentation: The rationale for three treatment sessions

Bauer, Ute; Graivier, Miles

doi:10.4172/plastic-surgery.1000702

Cited by 5 publications

(7 citation statements)

References 16 publications

(28 reference statements)

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“…[4][5][6] Results may not be evident for weeks after application, so it is important to wait for the biological reaction to occur between each application to avoid overcorrection. 10 For the face, the articles recommend 2 to 4 applications with intervals of 30-60 days between them. 6 Its mechanism of action has important implications for how the product should be applied, how to enhance its results and how to avoid adverse effects.…”

Section: Discussionmentioning

confidence: 99%

“…This fibroplasia will determine the cosmetic results, increasing the tissue volume in a gradual and progressive way, which can lead to the recovery of the collagen net and to the improvement of skin flaccidity over the months 4–6 . Results may not be evident for weeks after application, so it is important to wait for the biological reaction to occur between each application to avoid overcorrection 10 . For the face, the articles recommend 2 to 4 applications with intervals of 30–60 days between them 6 .…”

Section: Discussionmentioning

confidence: 99%

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Analysis of satisfaction patient and increased dermis thickness by medical evaluation and USG by Rennova Elleva in the treatment of sagging skin on the inner part of the arms

Cunha

Ferregutti

Bernardo

et al. 2022

Skin Health and Disease

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Introduction The flaccidity of the skin is provoked by changes caused by the chronological ageing of the skin, such as epidermal, dermal, and hypodermic thinning, which, in turn, are aggravated by photo ageing and by several other factors such as, for example, limited diets low in proteins, rapid weight loss and low BMI, liposuction, post‐pregnancy and stretch marks, which facilitate the loss of skin elasticity, even in young patients. Its treatment remains a major therapeutic challenge, as there are few procedures designed to effectively improve it. Objective To evaluate the satisfaction patient and increased dermis of Rennova Elleva in the treatment of cutaneous flaccidity of the inner part of the arms. Methods Twenty six women aged between 31 and 60 years old complaining of skin flaccidity in the medial area of the arms, with a severity score between: 1 (11 patients), 2 (10 patients) and 3 (5 patients) according to the scale Investigator Assessment Skin Laxity Scoring System (IASLSS), were treated with two applications of poly‐L‐lactic acid (PLLA) with intervals of 45 days between them. Results Forty five days after the second application of PLLA (D90), all patients presented a moderate to high degree of satisfaction with the treatment, with good tolerability and no adverse effects. Improvement was confirmed by high‐resolution ultrasound with an increase in dermal thickness between 23% and 70% (average value: 46%). Discussion Rennova Elleva® PLLA promoted an improvement in skin flaccidity and an increase in dermal thickness with good to excellent tolerability by patients. Conclusion The new presentation of PLLA proved to be effective and safe for the treatment of skin flaccidity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of satisfaction patient and increased dermis thickness by medical evaluation and USG by Rennova Elleva in the treatment of sagging skin on the inner part of the arms

Cunha

Ferregutti

Bernardo

et al. 2022

Skin Health and Disease

View full text Add to dashboard Cite

show abstract

“…4 Three to 4 sessions at 4-to 6-week intervals are recommended to achieve optimal correction. 5 Although encapsulated PLLA-SCA may degrade by 9 months, subsequent fibroblast induction and neocollagenesis can increase dermal thickness and volume for more than 2 years. 6 Most practitioners use PLLA-SCA to correct facial wrinkles and volume loss.…”

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confidence: 99%

A Randomized, Single-Center, Double-Blinded, Split-Body Clinical Trial of Poly-l-Lactic Acid for the Treatment of Cellulite of the Buttocks and Thighs

Almukhtar

Wood²,

Loyal

et al. 2023

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“…Injectable poly-L-lactic acid, calcium hydroxyapatite, and polycaprolactone are used to induce neocollagenesis. [5][6][7][8][9][10][11][12][13] The initial use of poly-L-lactic acid (PLLA) aimed to volumize the face using larger doses, at least one vial per session. 14 Hexsel and colleagues recently described a new technique 4 that delivers small amounts of collagen stimulators in the malar and preauricular areas to enhance the skin and subcutaneous tissue support.…”

mentioning

confidence: 99%

“…Injectable poly- l -lactic acid, calcium hydroxyapatite, and polycaprolactone are used to induce neocollagenesis. 5–13…”

mentioning

confidence: 99%

L-Lift Technique Using Poly-l-Lactic Acid: A Pilot Study

Hexsel

Camozzato

Valente-Bezerra

et al. 2021

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BACKGROUND Minimally invasive procedures that prevent and delay the aging process can be an alternative to more invasive surgical procedures. OBJECTIVE To assess the efficacy and safety of L-Lift technique to improve skin firmness, facial global aesthetics, and the patient and investigator satisfaction. METHODS Prospective, open, single-center study. Thirty participants underwent 3 treatment sessions 1 month apart and were assessed 8, 16, and 24 weeks after first injections. Assessments included the Facial Laxity Rating Scale (FLRS), Global Aesthetic Improvement Scale (GAIS), objective measurement of skin elasticity, and the Skin Distension Test. RESULTS At Week 24, 60% of the patients had at least 1-class improvement in the FLRS for the middle face and 33% for the lower face. At Week 24, investigators considered that 90.0% of the patients improved according to the GAIS and 90.0% of the subjects considered they have improved. Skin elasticity (at Week 8 and at Week 16) and Skin Distension Test (at Week 24) assessments indicated improvement in skin firmness. Both patients and investigators were satisfied with the treatment at the study end. CONCLUSION The technique is safe and efficacious. It may be particularly suitable for patients presenting initial signs of facial skin laxity.

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Optimizing injectable poly-L-lactic acid administration for soft tissue augmentation: The rationale for three treatment sessions

Cited by 5 publications

References 16 publications

Analysis of satisfaction patient and increased dermis thickness by medical evaluation and USG by Rennova Elleva in the treatment of sagging skin on the inner part of the arms

Analysis of satisfaction patient and increased dermis thickness by medical evaluation and USG by Rennova Elleva in the treatment of sagging skin on the inner part of the arms

A Randomized, Single-Center, Double-Blinded, Split-Body Clinical Trial of Poly-l-Lactic Acid for the Treatment of Cellulite of the Buttocks and Thighs

L-Lift Technique Using Poly-l-Lactic Acid: A Pilot Study

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