A randomized split‐face, investigator‐blinded study of a picosecond Alexandrite laser for post‐inflammatory erythema and acne scars

Wen, Xiang; Li, Yong; Hamblin, Michael R.; Jiang, Xian

doi:10.1111/dth.13941

Cited by 16 publications

(38 citation statements)

References 9 publications

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“…However, repetitive sessions were required to obtain an effective response. Pro‐yellow laser has achieved effective results even in a one single session, especially in postacne erythema 1 …”

Section: Discussionmentioning

confidence: 99%

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An evaluation of the efficacy of a single‐session 577 nm pro‐yellow laser treatment in patients with postacne erythema and scarring

Saraç

Kapıcıoğlu

Cenk

2020

Dermatologic Therapy

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Erythema and scarring are among the most common complications of severe inflammatory acne. In this study, we aimed to share our experience with pro‐yellow laser and document the efficacy and safety of this treatment in postacne erythema and scarring. The study included 40 patients, 24 (60%) females, and 16 (40%) males with a mean age of 29.5 ± 8.16 (min. 18 years, max. 57 years). The pro‐yellow laser was applied to all patients as a single session with irradiation of 22 J/cm2. Improvement in postacne erythema and scars were evaluated after the treatment. The study included 40 patients, 24 patients (60%) were females and 16 patients (40%) were males with the mean age of 29.5 ± 8.16 (ranged between 18 and 57 years old). A total of 21 patients (52.5%) had good improvement (51%‐75% regression), 10 patients (25%) had excellent improvement (76%‐100% regression), and a moderate improvement (26%‐50%) was detected in 9 patients (22.5%). Also, there were mild improvement (1%‐25%) in 20 patients (76.9%) and a moderate improvement (26%‐50%) in 6 patients (23.1%). We found that pro‐yellow laser is highly effective in the treatment of postacne erythema, while its effectiveness was mild to moderate in atrophic acne scars. Also, it has been observed that the pro‐yellow laser system can be used safely immediately after cessation of systemic isotretinoin treatment.

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Section: Discussionmentioning

confidence: 99%

“…Acne vulgaris is one of the most common dermatological disorders seen in adolescents. Postacne scars and erythema may be seen in up to 80% of patients with severe acne an even may be permanent in fair‐skinned population 1 …”

Section: Introductionmentioning

confidence: 99%

An evaluation of the efficacy of a single‐session 577 nm pro‐yellow laser treatment in patients with postacne erythema and scarring

Saraç

Kapıcıoğlu

Cenk

2020

Dermatologic Therapy

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“…No new adverse reactions were found, showing that the 1,064/532 nm picosecond laser therapy has satisfactory safety. Conversely, Wen et al (26) in the recent study showed some efficacy of picosecond Alexandrite laser in treating post-inflammatory erythema, implying that the LIOB effect may be used in erythema reduction and in stimulating collagen production.…”

mentioning

confidence: 95%

Comparison of fractionated frequency-doubled 1,064/532 nm picosecond Nd:YAG lasers and non-ablative fractional 1,540 nm Er: glass in the treatment of facial atrophic scars: a randomized, split-face, double-blind trial

Shi¹,

Jiang²,

Li³

et al. 2021

Ann Transl Med

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Background: Laser treatment of acne scars is common, but quality evidence on its efficacy is still needed.Our study aimed to compare picosecond laser and non-ablative fractional laser's efficacy and safety in treating acne atrophic scars.Methods: This was a randomized, split-face double-blind trial recruiting patients with acne atrophic scars. Facial halves were randomly divided and treated with fractionated frequency-doubled 1,064/532 nm picosecond Nd:YAG laser or non-ablative fractional 1,540 nm Er: glass laser. ECCA score (echelle d'evaluation clinique des cicatrices d'acne) and skin flatness measured with a non-invasive phaseshift rapid in vivo measurement of skin (PRIMOS) system were evaluated one month after the last treatment.Results: Twenty-two Fitzpatrick skin type IV patients were included in this study, with an average age of 29.68 years, an average duration of acne scars of 8.8 years. Picosecond laser impacted all acne scar types (before and after treatment; P=0.000 for all types, P<0.001 for V-type, P=0.002 for U-type, and P=0.021 for M-type) and more pronounced effect on ECCA score than non-ablative laser for V-type and U-type acne scars. After treatment, each treatment site's height was significantly lower than that before treatment (P=0.041) in the picosecond group but not in the non-ablative group (P=0.785). The reported erythema rate was higher in patients treated with a picosecond laser, while edema, exudation, purpura, pain, and long-term AEs were similar between the groups.Conclusions: Fractionated frequency-doubled 1,064/532 nm Picosecond Nd: YAG laser showed better efficacy in treating acne atrophic scars than the alternative and provided satisfactory safety with added improvement in pores and the glossiness of the skin.Registration number: ChiCTR2100045982 (comparison of fractionated frequency-doubled 1,064/532 nm picosecond Nd: YAG lasers and nonablative fractional 1,540 nm Er: glass in the treatment of facial atrophic scar: a randomized, split-face, double-blind controlled trial).

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“…Picosecond lasers deliver pulse durations in the picosecond range, much shorter, depending on the specifications of the individual device, than traditional nanosecond Q-switched lasers. 47 Additionally, picosecond lasers deliver lower fluences allowing these devices to generate a greater photoacoustic effect with less photothermal damage. 47 Wen et al demonstrated a statistically significant reduction in erythema using the Clinician Erythema Assessment Scale (CEAS) as well as a significant improvement in acne scars with minimal side effects in a split-face randomized study investigating the use of a 755nm picosecond Alexandrite laser for the treatment of post-inflammatory erythema and acne scarring.…”

Section: Lasersmentioning

confidence: 99%

“… 47 Additionally, picosecond lasers deliver lower fluences allowing these devices to generate a greater photoacoustic effect with less photothermal damage. 47 Wen et al demonstrated a statistically significant reduction in erythema using the Clinician Erythema Assessment Scale (CEAS) as well as a significant improvement in acne scars with minimal side effects in a split-face randomized study investigating the use of a 755nm picosecond Alexandrite laser for the treatment of post-inflammatory erythema and acne scarring. 47 Further studies investigating the role of picosecond lasers in the management of facial erythema are needed before reaching a conclusion regarding its utility in management of this common condition.…”

Section: Lasersmentioning

confidence: 99%

Updates and Best Practices in the Management of Facial Erythema

Loyal¹,

Carr²,

Almukhtar³

et al. 2021

CCID

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Facial erythema is a common dermatologic complaint. There are many medical and procedure-based treatments to help reduce the appearance of unwanted facial redness. The authors review a variety of treatment options and techniques to reduce facial erythema and prominent facial veins including topical medical therapies, a variety of lasers, light- and energy-based devices as well as the use of neuromodulators and sclerotherapy. The benefits and potential pitfalls of each procedure modality are also highlighted.

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A randomized split‐face, investigator‐blinded study of a picosecond Alexandrite laser for post‐inflammatory erythema and acne scars

Cited by 16 publications

References 9 publications

An evaluation of the efficacy of a single‐session 577 nm pro‐yellow laser treatment in patients with postacne erythema and scarring

An evaluation of the efficacy of a single‐session 577 nm pro‐yellow laser treatment in patients with postacne erythema and scarring

Comparison of fractionated frequency-doubled 1,064/532 nm picosecond Nd:YAG lasers and non-ablative fractional 1,540 nm Er: glass in the treatment of facial atrophic scars: a randomized, split-face, double-blind trial

Updates and Best Practices in the Management of Facial Erythema

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