A randomized, single-blind, active controlled study to compare the efficacy of salicylic acid and mandelic acid chemical peel in the treatment of mild to moderately severe acne vulgaris

Jartarkar, ShishiraR; Gangadhar, Bugude; Mallikarjun, M; Manjunath, P

doi:10.4103/wkmp-0150.196946

Cited by 9 publications

(19 citation statements)

References 1 publication

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“…38 Its effectiveness has been proven in the treatment of both inflammatory and noninflammatory acnes. 38,39 In addition, it is effective against postinflammatory hyperpigmentation (PIH) caused by acne 40 via its desquamating effect. 41 Low concentrations of salicylic acid with a good safety profile are also available as over-the-counter products for acne treatment.…”

Section: Discussionmentioning

confidence: 99%

Acne treatment efficacy of intense pulsed light photodynamic therapy with topical licochalcone A, l‐carnitine, and decanediol: A spilt‐face, double‐blind, randomized controlled trial

Wanitphakdeedecha

Tavechodperathum

Tantrapornpong

et al. 2019

J of Cosmetic Dermatology

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Background: Depending on disease severity, standard acne treatments can vary from topical to systemic therapy. However, poor compliance caused by adverse events and antibiotic resistance is a major cause of treatment failure. Aims: To determine the effectiveness of photodynamic therapy (PDT) with intense pulsed light (IPL) in the treatment of acne when combined with a cream containing licochalcone A, L-carnitine and decanediol (so-called, 'active formulation') versus PDT alone. Patients/Methods: Twenty-nine volunteers, aged 21-39 years (26 women and 3 men, mean age 29.41 ± 5.24 years), with mild to severe facial acne, were enrolled. Each subject's face sides were randomized in a split-face manner to either receive PDT (IPL with a 400-720 nm cutoff filter, at 4 sessions with two-week intervals) combined with the active formulation cream twice daily for 10 weeks on one face side; or PDT and the vehicle cream on the other side, with the same treatment protocol. Reduction in acne quantity, melanin index and erythema index were assessed 2 weeks after the second treatment (day 28), 1 week after the fourth treatment (day 49), and 1 month after the fourth treatment (day 70). Results: Compared to baseline, patients in the active formulation group demonstrated a faster onset of reduction in the number of lesions at 2 weeks after the second treatment (p=0.010 for inflammatory acne and p=0.001 for non-inflammatory acne). A significantly greater reduction in lesion count was observed in the active formulation group compared with the vehicle group at all timepoints of evaluation for noninflammatory acne (day 28, day 49, and day 70; p=0.003, 0.005 and 0.002 respectively), and at 1 month after the fourth treatment for inflammatory acne (p=0.036). Compared to the vehicle group, the melanin index of the active formulation group decreased significantly at 1 month after the fourth treatment (p=0.015).

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Section: Discussionmentioning

confidence: 99%

Acne treatment efficacy of intense pulsed light photodynamic therapy with topical licochalcone A, l‐carnitine, and decanediol: A spilt‐face, double‐blind, randomized controlled trial

Wanitphakdeedecha

Tavechodperathum

Tantrapornpong

et al. 2019

J of Cosmetic Dermatology

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“…Several authors have studied the effectiveness of different single peeling agents in the treatment of acne vulgaris, and they all reported significant improvement in the acne lesions . On the other hand, only one study by Garg et al had evaluated the use of combination peels vs single peel in the treatment of acne vulgaris.…”

Section: Discussionmentioning

confidence: 99%

Combination chemical peels are more effective than single chemical peel in treatment of mild‐to‐moderate acne vulgaris: A split face comparative clinical trial

Nofal

Gharib

et al. 2018

J of Cosmetic Dermatology

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“…A previous study by Shishira et al (10) reported that Salicylic acid peel was more productive than Mandelic acid peel. However, the side effects were less familiar with no post-inflammatory hyperpigmentation with the Mandelic acid peel.…”

Section: Introductionmentioning

confidence: 92%

Salicylic Acid Peel and Fusion Peel with Salicylic & Mandelic Acid Peel for Treatment of Acne Scars - A Comparative Study

Muthu¹,

Gopalan²,

Muthu

2020

Serbian Journal of Dermatology and Venereology

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Introduction. Acne vulgaris is one of the most common skin diseases affecting more than 85% of individuals worldwide. The study aimed to compare the therapeutic efficacy of Salicylic acid peel and Salicylic acid - mandelic acid peel for treatment of acne scars. Material and Methods. A comparative study was conducted on 41 patients, divided into two groups based on treatment choice by the subjects. Group A (23) were treated with 30% salycilic acid peels, and group B (18) were treated with 20% salycilic acid and 10% mandelic acid peels at an interval of 2 weeks for three sessions. The physician’s global assessment scale and clinical photographs were used at the end of three sessions. All the data were analysed using SPSS considering P<0.05 as significant. Results. Of the total 41 patients analyzed, the mean age in both the groups were comparable. (Group A: 20.4 years; Group B: 20.5 years). Duration of acne was >12 months in both the groups 13 (56.52%) & 10 (55.56%)). Thirteen patients (56.52%) in group A and 1 (5.56%) in group B had no side effects which was statistically significant (p=0.01). Using the physician’s global assessment scale 51-75% (Good) an improvement was seen in grade I 4 (17%) and 18 (78%) in grade II in group A and 2 (11%) in grade I and 12 (67%) in grade II in group B, respectively which was statistically significant (p=0.001). Conclusion. Both agents showed almost equal efficacy in improving mild-to-moderate acne scars. Adverse effects were less with Salicylic acid peel compared with mandelic acid peel..

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A randomized, single-blind, active controlled study to compare the efficacy of salicylic acid and mandelic acid chemical peel in the treatment of mild to moderately severe acne vulgaris

Cited by 9 publications

References 1 publication

Acne treatment efficacy of intense pulsed light photodynamic therapy with topical licochalcone A, l‐carnitine, and decanediol: A spilt‐face, double‐blind, randomized controlled trial

Acne treatment efficacy of intense pulsed light photodynamic therapy with topical licochalcone A, l‐carnitine, and decanediol: A spilt‐face, double‐blind, randomized controlled trial

Combination chemical peels are more effective than single chemical peel in treatment of mild‐to‐moderate acne vulgaris: A split face comparative clinical trial

Salicylic Acid Peel and Fusion Peel with Salicylic & Mandelic Acid Peel for Treatment of Acne Scars - A Comparative Study

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