A Randomized, Placebo-Controlled Trial of Topical Retinol in the Treatment of Cellulite

Piérard-Franchimont, C; Pierard, Gérald; Henry, Frédérique; Vroome, Valérie; Cauwenbergh, G.

doi:10.2165/00128071-200001060-00005

Cited by 44 publications

(31 citation statements)

References 24 publications

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“…At the latter sites, edema and deposits of proteoglycans may be present in association with alterations in the shape and pattern of distribution of the elastic fibers 4,7 . Such histological changes found in the hypodermis of cellulite are reminiscent of the dermal changes found in striae distensae 4,7,12 …”

Section: Skin Structure Alterations In Cellulitementioning

confidence: 99%

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Commentary on cellulite: skin mechanobiology and the waist‐to‐hip ratio

Pierard

2005

J of Cosmetic Dermatology

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Cellulite is a gender-related condition which is the clinical expression of conformational changes taking place in the fibrous strands partitioning the hypodermis. The affected skin areas are those where fat deposition is under the influence of estrogens. Some hypodermal fibrous strands become enlarged and others become loose and look similar to striae distensae. Cellulite is not a result of increased body mass, but its aspect may be influenced by the waist-to-hip ratio.

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Section: Skin Structure Alterations In Cellulitementioning

confidence: 99%

“…Histological studies of cellulite are few but contradictory 4–7,10–12 . Globally, we view cellulite as the result of a combination of the gender‐related dimorphism of the hypodermal connective tissue and the mechanobiological effects of tissue tensions inside this tissue 4 .…”

Section: Skin Structure Alterations In Cellulitementioning

confidence: 99%

Commentary on cellulite: skin mechanobiology and the waist‐to‐hip ratio

Pierard

2005

J of Cosmetic Dermatology

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“…Moreover, a mixture of retinol, caffeine, and ruscogenin was able to reduce the orange-peel appearance and increase microcirculation in a clinical study reported by Bertin et al19 Single ingredients, also found in this formulation have documented anti-cellulite activity as well. This is the case for retinol, which by itself, improves skin thickness in patients with cellulite, as demonstrated clinically by Kligman et al,20 while Piérard-Franchimont et al21 reported effects on tensile properties of skin, in the context of cellulite. Acting to strengthen capillaries and limit edema when applied topically, escin, derived from horse chestnut, is another ingredient of the current gel that has found application in anti-cellulite formulations 22,23…”

Section: Introductionmentioning

confidence: 76%

An integral topical gel for cellulite reduction: results from a double-blind, randomized, placebo-controlled evaluation of efficacy

Dupont¹,

Journet²,

Oula³

et al. 2014

CCID

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BackgroundCellulite is a serious cosmetic concern for most of the 90% of women affected by it.ObjectiveTo assess the clinical efficacy of a complex integral anti-cellulite gel.MethodsThis double-blind, randomized, placebo-controlled study involved 44 healthy women, aged 25–55 years. Subjects had a normal to slightly overweight body mass index and presented slight to moderate cellulite on their thighs, buttocks, and/or hips at baseline. Subjects were randomly assigned to either the treated or placebo group and accordingly applied the active product or placebo on their hips, stomach, buttocks, and thighs, twice daily for 3 months. Skin tonicity, orange-peel aspect, and stubborn cellulite were assessed at day 0, 28, 56, and 84. A self-evaluation questionnaire was completed by all volunteers.ResultsAt the end of the study, an average of 81% of the subjects applying the active product presented improvement in their cellulite condition versus 32% for the placebo group (all descriptors and sites combined). At day 84, skin tonicity, orange-peel appearance, and stubborn cellulite were improved in a significant manner (P<0.05) over placebo, on all studied areas. Skin tonicity improved on average by +41% for buttocks, +35% for hips, and +31% for thighs. Orange peel appearance was reduced on average by −25% for buttocks, −22% for hips, and −22% for thighs. Stubborn cellulite was reduced on average by −19% for buttocks, −24% for hips, and −22% for thighs. Circumference measurements decreased in a significant manner (P<0.05) over placebo, for the abdomen (average value of −1.1 cm) and thighs (average value of −0.8 cm). The product was well tolerated and perceived by the volunteers themselves as better performing than placebo on all criteria.ConclusionAll results validate the efficacy of the present integral formulation to significantly reduce signs of cellulite and reshape the silhouette.

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“…14 RCTs [18][19][20][21][22][23][24][25][26][27][28][29][30][31], eine Metanalyse inklusive systematischem Review [32] und 2 Beobachtungsstudien [33,34] ohne schließende Statistik wurden bereits verö entlicht. Insgesamt wurden 600 Patienten in diesen klinischen Studien untersucht, die meistens Kombinationsprodukte mit Ko ein und/oder Retinol in Kombination mit p anzlichen Inhaltssto en verwendeten.…”

Section: Topische Wirkstoffeunclassified

Evidenzbasierte Methoden zur Behandlung der Cellulite

Lübberding

2015

ästhet dermatol kosmetol

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A Randomized, Placebo-Controlled Trial of Topical Retinol in the Treatment of Cellulite

Cited by 44 publications

References 24 publications

Commentary on cellulite: skin mechanobiology and the waist‐to‐hip ratio

Commentary on cellulite: skin mechanobiology and the waist‐to‐hip ratio

An integral topical gel for cellulite reduction: results from a double-blind, randomized, placebo-controlled evaluation of efficacy

Evidenzbasierte Methoden zur Behandlung der Cellulite

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