A randomized, placebo-controlled study of donepezil in poststroke aphasia

Berthier, Marcelo L.; Green, C.; Higueras, Carolina; Fernández, Inmaculada; Hinojosa, Julían; Martin, Mauricio

doi:10.1212/01.wnl.0000242626.69666.e2

Cited by 129 publications

(95 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…508 Several small RCTs have shown that drug therapy appears to be beneficial in conjunction with SLT, whereas other studies have failed to show a benefit. Drugs showing promise include donepezil, 509 memantine, 510 and galantamine. …”

Section: Aphasiamentioning

confidence: 99%

Guidelines for Adult Stroke Rehabilitation and Recovery

Winstein¹,

Stein²,

Arena

et al. 2016

Stroke

1,903

709

View full text Add to dashboard Cite

e98Purpose-The aim of this guideline is to provide a synopsis of best clinical practices in the rehabilitative care of adults recovering from stroke. Methods-Writing group members were nominated by the committee chair on the basis of their previous work in relevant topic areas and were approved by the American Heart Association (AHA) Stroke Council's Scientific Statement Oversight Committee and the AHA's Manuscript Oversight Committee. The panel reviewed relevant articles on adults using computerized searches of the medical literature through 2014. The evidence is organized within the context of the AHA framework and is classified according to the joint AHA/American College of Cardiology and supplementary AHA methods of classifying the level of certainty and the class and level of evidence. The document underwent extensive AHA internal and external peer review, Stroke Council Leadership review, and Scientific Statements Oversight Committee review before consideration and approval by the AHA Science Advisory and Coordinating Committee. Results-Stroke rehabilitation requires a sustained and coordinated effort from a large team, including the patient and his or her goals, family and friends, other caregivers (eg, personal care attendants), physicians, nurses, physical and occupational therapists, speech-language pathologists, recreation therapists, psychologists, nutritionists, social workers, and others. Communication and coordination among these team members are paramount in maximizing the effectiveness

show abstract

Section: Aphasiamentioning

confidence: 99%

Guidelines for Adult Stroke Rehabilitation and Recovery

Winstein¹,

Stein²,

Arena

et al. 2016

Stroke

1,903

709

View full text Add to dashboard Cite

show abstract

“…Donepezil is a dose-dependent acetylcholinesterase inhibitor with a selective central action. In a randomized placebo controlled study published in 2006, the donepezil group showed significant improvement in aphasia severity at the endpoint (week 16) relative to placebo in post-stroke aphasia patients one year after stroke onset [17]. …”

Section: Pharmacologic Interventionsmentioning

confidence: 99%

Current Evidence for Post Stroke Aphasia Treatment

Yang

2017

Brain Neurorehabil

View full text Add to dashboard Cite

Aphasia is a major devastating symptom in stroke survivors that deteriorates patient quality of life. Various treatment methods are applied for aphasia patients after stroke. Evidence is required to assess the effectiveness of variable therapy for aphasia. Results of a meta-analysis have concluded that speech and language treatment is effective post stroke. Better outcomes are expected with high dose and high intensity speech and language therapy within tolerable ranges. Computerized and group treatments can supplement classic one to one speech and language therapy. Pharmacotherapy and non-invasive brain stimulation combined with speech and language therapy have been well-studied and better outcomes are expected, however testing in a large number of subjects is required to validate the efficacy of these combined modalities.

show abstract

“…They, compared with patients receiving placebo, showed significant refined naming skill at the end of treatment. Aphasia quotient and verbal communication ability improved in treatment rather than control group, but treatment-induced improvement was not persistent in the four weeks washout period (41). In a similar study, not considering control group, 5 mg/daily donepezil in 4 first weeks of the treatment phase and 10 mg/daily in 12 weeks later in aphasic patients were assessed.…”

Section: 1clinical Trialsmentioning

confidence: 99%

“…Among the numerous clinical trials focused on the effect of drug on improvement of aphasia and cognitive deficits in patients with primary progressive aphasia (PPA), Alzheimer, vascular dementia, acute and chronic brain stroke and head trauma, the role of memantine as voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptor (9,38), and anticholinesterase drugs such as donepezil (39)(40)(41)(42)(43)(44)(45)(46), galantamine (47,48) and physostigmine (49) are remarkable.…”

Section: Effective Drugs On Central Cholinergic and Glutamatergic Sysmentioning

confidence: 99%

Pharmacotherapy to Improve the Acquired Aphasia following Brain Damages: A Review Study

Ramezani

Reihanian

Yousefzadeh-Chabok

et al. 2015

IrJNS

View full text Add to dashboard Cite

Background & Aim: Using pharmaceutical agents in treatment of aphasia has caught the attention of many neurologists and neuroscientists. This short review study has sought the role of pharmacotherapy in treatment of aphasia, a linguistic impairment after acquired brain lesions. The pharmacological principles and mechanisms related to the effects of drugs used in aphasia rehabilitation are pointed. Then, some evidence of clinical trials on different drugs in this field is presented. Methods & Materials/Patients:A comprehensive search in databases including MEDLINE, Cochrane, PubMed, Scopus, EMBASE, Science Direct on experimental studies and clinical trials associated with pharmacotherapy of aphasia after neurological damages was performed.

show abstract

A randomized, placebo-controlled study of donepezil in poststroke aphasia

Abstract: We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).

Cited by 129 publications

References 7 publications

Guidelines for Adult Stroke Rehabilitation and Recovery

Guidelines for Adult Stroke Rehabilitation and Recovery

Current Evidence for Post Stroke Aphasia Treatment

Pharmacotherapy to Improve the Acquired Aphasia following Brain Damages: A Review Study

Contact Info

Product

Resources

About