A randomized, multicenter, controlled study, comparing efficacy and safety of a new complementary and alternative medicine (CAM) versus Solifenacin Succinate in women with overactive bladder syndrome

Vecchioli-Scaldazza, Carlo; Morosetti, Carolina; Maruccia, Serena; Casellato, Stefano; Rociola, W.; Illiano, Ester; Garofalo, F

doi:10.4081/aiua.2017.4.296

Cited by 11 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…52 Recent trials using P. cuspidatum have not reported significant toxicity. 53,54 In this current study, clinically used antibiotics for treating Bartonella-associated infections, including AZI and DOX, showed weak activity in eradicating stationary phase B. henselae cells (Table 1, Figure 1, and Figure 2). This finding coincides with the reported discrepancies in antibiotic efficacies between in vitro MIC data and clinical data from patients.…”

Section: Discussionmentioning

confidence: 71%

See 1 more Smart Citation

Botanical Medicines With Activity Against Stationary Phase Bartonella henselae

Leone²,

Schweig³

et al. 2021

Infectious Microbes and Diseases

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 71%

“…A study investigating the mechanism of action of P. cuspidatum using a network pharmacology approach suggested that the component polydatin might play a pivotal role in the therapeutic effects of P. cuspidatum 52 . Recent trials using P. cuspidatum have not reported significant toxicity 53,54 …”

Section: Discussionmentioning

confidence: 99%

Botanical Medicines With Activity Against Stationary Phase Bartonella henselae

Leone²,

Schweig³

et al. 2021

Infectious Microbes and Diseases

View full text Add to dashboard Cite

show abstract

“…18 In a multicenter randomized controlled trial, Vecchioli-Scaldazza et al. 19 have compared Kubiker with Solifenacin Succinate in women with OAB, demonstrating the effectiveness and good tolerability profile of this CAM.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, patients with OAB are usually proposed to follow anti-muscarinic therapies, which are often discontinued because of adverse effects, poor efficacy, or drug costs. 18 In a multicenter randomized controlled trial, Vecchioli-Scaldazza et al 19 have compared Kubiker with Solifenacin Succinate in women with OAB, demonstrating the effectiveness and good tolerability profile of this CAM.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of a complementary and alternative medicine based on vitamins, herbal products, and amino acid as a first line treatment in idiopathic overactive bladder syndrome in men and women without bladder outlet obstruction

et al. 2022

View full text Add to dashboard Cite

Objective: To evaluate the efficacy and tolerability of a complementary and alternative medicine (CAM) called Kubiker (Naturmed, Montegranaro, FM, Italy), consisting of vitamins (C and D), herbal products (cucurbita maxima, capsicum annum, polygonum cuspidatum), and amino acid L-Glutamine, as first line treatment of (OAB) Materials and methods: According to institutional protocols, data on patients addressing to a tertiary referral centre for OAB symptoms were recorded. OAB was evaluated through validated questionnaires including ICIQ-SF, USS, and OAB-q-SF. Patients with previous antimuscarinic or β3 agonist treatment, neurological disease or pathologies which may mimic OAB, including infections, were excluded. Only unobstructed patients were considered and were given CAM twice daily for 12 weeks. After treatment, symptoms were re-evaluated repeating previous questionnaires and PGI-I was given to evaluate perceived improvement. Results: A total of 41 patients were evaluated and 35 respected inclusion criteria and were enrolled. All subjects had a full compliance and adherence with CAM medication intake. The median patient’s age was 65 (56–73). Male were 8 (22.9%) while females were 27 (77.1%). Median baseline OAB-q SF and ICIQ-SF scores were 18 (15–25) and 9 (6–13), respectively. After treatment, 85.7% patients had a clinical benefit, with a significant reduction of OAB symptoms, also according to USS ( p < 0.01). The median OAB-q SF and ICIQ-SF scores were 10 (7–15) and 6 (0–8) ( p < 0.01). CAM was successful with an improvement in subjective patient’s satisfaction, with a median PGI-I score of 2 (1–3). Patients (men and women) who still had UUI after 3 months CAM medication were eight (22.8%), and among them, those who did not refer any therapeutic benefit were five (14.3%) Conclusions: According to our study, CAM may be useful medication for a first line treatment of uncomplicated idiopathic OAB cases, providing a nonnegligible effects on symptoms. However, further studies are mandatory to draw definitive conclusions

show abstract

“…A study unraveling the mechanism of action of Polygonum cuspidatum using a network pharmacology approach, suggested that polydatin might play a pivotal role in the therapeutic effects of Polygonum cuspidatum [98]. Recent trials using Polygonum cuspidatum have not reported significant toxicity [99, 100]. One of the active constituents, resveratrol, has been shown to be rapidly absorbed [101], well-tolerated [102] and associated with minimal toxicity except mild diarrhea at an oral dose of 2000mg 2x/day for 2 weeks [103].…”

Section: Discussionmentioning

confidence: 99%

Botanical Medicines with Activity against Stationary PhaseBartonella henselae

Leone²,

Schweig³

et al. 2020

Preprint

View full text Add to dashboard Cite

Bartonella henselae is a Gram-negative, facultative intracellular bacterium which is the causative agent of cat scratch disease. In humans, infections with B. henselae can result in acute or chronic systemic infections with various clinical symptoms including local skin lesions, malaise, aches, chills, lymphadenopathy, endocarditis, or meningoencephalitis. The current treatment for Bartonella infections with antibiotics such as doxycycline and rifampin is not always effective presumably due to bacterial persistence. There have been various anecdotal reports of herbal extracts used for treating patients with persistent Bartonella infections but their activity on B. henselae is unknown. To test the potential antimicrobial activity of botanical or herbal medicines and develop better therapies for persistent Bartonella infections, in this study, we screened an herbal product collection against stationary phase B. henselae in vitro using SYBR Green I/ propidium iodide (PI) viability assay. These herbal medicines were selected by the fact that they are commonly used to treat Lyme and co-infections by patients and herbalists, and as a follow-up to our recent study where these herbs were tested against B. burgdorferi. We identified five herbal product extracts that had high activity against stationary phase B. henselae at 0.5% (v/v), including Cryptolepis sanguinolenta, Juglans nigra, Polygonum cuspidatum, Scutellaria baicalensis, and Scutellaria barbata. Among them, Cryptolepis sanguinolenta, Juglans nigra, and Polygonum cuspidatum could eradicate all stationary phase B. henselae cells within 7 days at 0.25% (v/v) in drug exposure time-kill assay, whereas Scutellaria baicalensis and Scutellaria barbata showed relatively poor activity. The minimum inhibitory concentration (MIC) determination of these top hits indicated they were not only active against stationary phase non-growing B. henselae but also had good activity against log phase growing B. henselae. Our findings may help to develop more effective treatments for persistent Bartonella infections.

show abstract

A randomized, multicenter, controlled study, comparing efficacy and safety of a new complementary and alternative medicine (CAM) versus Solifenacin Succinate in women with overactive bladder syndrome

Abstract: the small number of patients does not permit definitive conclusions; however, the results of the research showed the greater effectiveness and tolerability of CAM.

Cited by 11 publications

References 21 publications

Botanical Medicines With Activity Against Stationary Phase Bartonella henselae

Botanical Medicines With Activity Against Stationary Phase Bartonella henselae

Outcomes of a complementary and alternative medicine based on vitamins, herbal products, and amino acid as a first line treatment in idiopathic overactive bladder syndrome in men and women without bladder outlet obstruction

Botanical Medicines with Activity against Stationary PhaseBartonella henselae

Contact Info

Product

Resources

About