Botanical Medicines With Activity Against Stationary Phase Bartonella henselae

Abstract

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The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses

“…Zhang and colleagues [ 74 ] provided in vitro evidence that C. sanguinolenta had efficacy against Borrelia burgdorferi , Bartonella henselae , and Babesia duncani , with good efficacy against both growing and stationary forms. Ma and colleagues [ 133 ] also identified efficacy against Bartonella stationary and active log phase forms. Of multiple agents studied, cryptolepine had the strongest inhibitory activity against Babesia duncani , including traditional combinations of quinine and clindamycin.…”

“…Regarding potential impacts on Borrelia burgdorferi and Borrelia garinii , Juglans nigra has exhibited bacteriostatic activity against log phase spirochetes of B. burgdorferi and B. garinii and bactericidal activity against Borrelia round bodies [ 137 ]. Ma and colleagues [ 133 ] also identified efficacy against stationary and active log phase forms of Bartonella . Although reports of gastrointestinal disturbance [ 142 ] and changes in skin pigmentation have been published [ 143 , 144 ], Juglans nigra is generally well-tolerated and side effects are uncommon.…”

“…According to Zhang and colleagues [ 74 ], P. cuspidatum showed a good inhibitory effect against Babesia duncani and Bartonella henselae . Ma and colleagues [ 133 ] also identified P. cuspidatum efficacy against Bartonella stationary and active log phase forms [ 133 ]. P. cuspidatum has been found to have minimal toxicity in animal and human studies.…”