A Randomized, Evaluator-Blinded, Controlled Study of Effectiveness and Safety of Small Particle Hyaluronic Acid Plus Lidocaine for Lip Augmentation and Perioral Rhytides

Beer, Kenneth; Glogau, Richard G.; Dover, Jeffrey S.; Shamban, Ava; Handiwala, Lata; Olin, Jason T.; Bulley, Brian

doi:10.1097/dss.0000000000000199

Cited by 30 publications

(26 citation statements)

References 8 publications

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“…The most commonly used assessment scale was the photonumeric Lip Fullness Scale (LFS). Three different LFS were used: Medicis LFS, Allergan LFS, and Lip Fullness Grading Scale . For the number of points on the scales and its descriptive definitions, see Table .…”

Section: Resultsmentioning

confidence: 99%

“…In four randomized controlled studies, the authors defined severity and duration of AEs. Most subjects reported treatment‐related AEs as mild (range 71%‐88%) or moderate (range 11%‐16%) in severity.…”

Section: Resultsmentioning

confidence: 99%

“…The primary efficacy endpoint was an increase in lip fullness for at least one grade on different lip fullness scales (MLFS, ALFS, or LFGS). Observed responses to the treatment in studies using those scales varied between 71% and 93.2%. At 12 months, the response rate varied between 48.3% and 60%.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness and safety of hyaluronic acid fillers used to enhance overall lip fullness: A systematic review of clinical studies

Stojanovič

Majdič

2019

J of Cosmetic Dermatology

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Background:The majority of aesthetic treatments today are nonsurgical or minimally invasive aesthetic procedures. Soft-tissue augmentation with hyaluronic acid (HA) is one of them. Lip fullness and definition are key aesthetic factors associated with attractiveness, which is the reason that lip augmentation with HA fillers has become so popular.Objective: To provide a systematic review of published medical literature on the effectiveness and safety of different HA fillers used to enhance overall lip fullness. Methods and materials:The literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Twenty-two studies were included in the qualitative synthesis, 9 of them with level of evidence (LOE) 1b (randomized controlled trials), 1 with LOE 2b (individual cohort study), and 12 with LOE 4 (case series, poor-quality cohort, and case-control studies). A total number of subjects included in all studies were 3965. Results:Hyaluronic acid fillers turned out to be an effective and safe treatment. The assessment methods (especially for efficacy) varied greatly from one study to another. Observed responses to the treatment in studies using different lip fullness scales varied between 71% and 93.2%. The most common adverse events were local reactions at the injection sites (swelling, contusion, bruising, pain, redness, and itching). Conclusion:Based on the results of the studies included in this systematic review, HA fillers are effective and safe to use. The majority of included subjects were satisfied with the result and their looks. K E Y W O R D S efficacy, filler, hyaluronic acid, lips, safety

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effectiveness and safety of hyaluronic acid fillers used to enhance overall lip fullness: A systematic review of clinical studies

Stojanovič

Majdič

2019

J of Cosmetic Dermatology

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“…Patient examination is mandatory and should involve assessing superior and inferior labial units, shape, contour, projection, volume, support, asymmetries, patient's smile and facial ageing ( Figure 1). Many Authors [2][3][4][5][6] in the literature have published the rate of side effects like pain, post treatment discomfort, bruising, swelling and asymmetries in lip injection with hyaluronic acid considered common or very common in their experience. Despite mounting evidence that classical technique in lip injection may actually have higher side effects rates, many phisycians and many surgeons are reluctant to change their practice to adopting a procedure that can lower or totally eliminate this risk.…”

Section: Introductionmentioning

confidence: 99%

Decrease in Side Effects Rate after Adopting Bloodless Atraumatic Technique (BAT) - A Single Cosmetic Surgery Center Experience of 360 Lip Injections Over One Year

Noviello¹,

Santis²,

Maroni³

et al. 2018

J Med - Clin Res & Rev

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Introduction: The most popular non-surgical procedures continue to be injectables with hyaluronic acid ranking at number two, including lip augmentation which is gaining in interest and represents a large portion of cosmetic medicine practice in recent years. Although it is considered a simple technique, we often observe poor quality results. Many Authors in the literature have published the rate of side effects like pain, post treatment discomfort, bruising, swelling and asymmetries in lip injection with hyaluronic acid considered common or very common in their experience. A cosmetic improvement of the lips involves many precautionary considerations. In this study we examine our single accredited outpatient cosmetic medicine and surgery center experience transitioning from the use of traditional injection technique to the use of Boodless Atraumatic Technique (BAT). Methods: We performed a retrospective analysis of all lip injection cases performed over a 1-year period from January 2017 to December 2017 by multiple physicians and surgeons in the practice. During the 1-year period, there were 360 lip enhancement with filler performed by three attending doctors. Post-treatment follow-up length and complications including swelling, bruising, long lasting edema (more than 14 days), infection, seroma, granuloma, skin necrosis and need for revision were noted. Results: Three of the most interesting findings were a significantly decreased pain level and discomfort, bruising and swelling in the BAT group (258 patients) where no pain occurred in 43.02%, light pain in 42.24%, moderate pain in 14.72%, intense or serious pain in 0%. Whereas serious pain occurred in the Traditional Infiltration Technique (TIT) group (102 patients) in 25.49%, intense pain in 68.62%, moderate pain in 5.88%, light or no pain in 0%. We found in the BAT group that bruising occurred in 3.87% vs 25.49% in the TIT group and swelling in 4.65% vs 29.41%. Other sensitive element was the decrease rate of long lasting edema (more than 14 days) with 0.77% in the BAT patients and 5.88% in the TIT group. Discussion: Pain level and discomfort in the Bloodless Atraumatic Technique Lip Injection Group were much lighter than that in the Traditional Infiltration Technique Group, which demonstrated that BAT significantly reduced post treatment pain and discomfort. Improvement of facial harmony requires a strong knowledge of the anatomy. Most lip injections are performed without a clear understanding of the underlying oral and perioral anatomy. Conclusions: The Bloodless Atraumatic Technique allows to enhance the lip with control and precision without violating important and sensitive anatomical structure like mucosa, labial arteries and orbicularis oris muscle which reduces pain, postoperative discomfort, swelling, bruising, long lasting edema and the possibility of infection. Bloodless Atraumatic Technique Lip Injection offers objective improvements in side effects and complications, recovery and the overall patient experience, but do not happen in a predictable ...

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“…As a control, we used a biphasic hyaluronic acid filler containing 0.3% lidocaine, Restylane Perlane-L (Perlane-L; Q-Med, Uppsala, Sweden). 12 Both products have the same hyaluronic acid particle size and are cross-linked with butanediol diglycidyl ether. Both fillers are prepared in the same hyaluronic acid concentration of 20 mg/g but have different degrees of hyaluronic acid cross-linking and gel calibration.…”

mentioning

confidence: 99%

A Randomized Clinical Trial to Evaluate the Efficacy and Safety of Lidocaine-Containing Monophasic Hyaluronic Acid Filler for Nasolabial Folds

Joo

Woo

Kim

et al. 2016

Plastic and Reconstructive Surgery

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A Randomized, Evaluator-Blinded, Controlled Study of Effectiveness and Safety of Small Particle Hyaluronic Acid Plus Lidocaine for Lip Augmentation and Perioral Rhytides

Abstract: Small particle hyaluronic acid plus lidocaine was effective and well tolerated and significantly more effective when both lips and perioral rhytides were treated, with improvement evident up to 6 months after treatment.

Cited by 30 publications

References 8 publications

Effectiveness and safety of hyaluronic acid fillers used to enhance overall lip fullness: A systematic review of clinical studies

Effectiveness and safety of hyaluronic acid fillers used to enhance overall lip fullness: A systematic review of clinical studies

Decrease in Side Effects Rate after Adopting Bloodless Atraumatic Technique (BAT) - A Single Cosmetic Surgery Center Experience of 360 Lip Injections Over One Year

A Randomized Clinical Trial to Evaluate the Efficacy and Safety of Lidocaine-Containing Monophasic Hyaluronic Acid Filler for Nasolabial Folds

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