A randomized, double-blind, vehicle-controlled, bilateral comparison trial of bexarotene gel 1% versus vehicle gel in combination with narrowband UVB phototherapy for moderate to severe psoriasis vulgaris

Magliocco, Melissa; Pandya, Komal; Dombrovskiy, Viktor Y.; Christiansen, Linda; Wong, Yuk Wo; Gottlieb, Alice B.

doi:10.1016/j.jaad.2005.09.012

Cited by 17 publications

(8 citation statements)

References 6 publications

(5 reference statements)

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“…4 It has been used in combination with a variety of topical and systemic therapies. [5][6][7][8][9] To the best of our knowledge, there are only two studies in literature that have combined methotrexate and UVB and found the combination capable of clearing psoriasis in significantly less time and with a lower cumulative dose of UVB. 10,11 This study was undertaken to evaluate the usefulness of methotrexate ⁄ NBUVB combination in the treatment of moderate to severe psoriasis in Indian population.…”

Section: Introductionmentioning

confidence: 99%

“…Ever since its introduction in 1988, narrowband ultraviolet B (NBUVB) phototherapy has shown good efficacy in the treatment of psoriasis and currently represents the most effective UVB phototherapy for psoriasis 4 . It has been used in combination with a variety of topical and systemic therapies 5–9 . To the best of our knowledge, there are only two studies in literature that have combined methotrexate and UVB and found the combination capable of clearing psoriasis in significantly less time and with a lower cumulative dose of UVB 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…Baseline characteristics of the study population Venereology 196 ± 80.89 mg (90-405 mg). Mean number of weeks for which treatment was continued in group A was 7.50 ± 3.03 weeks (4-16) and 13.50 ± 6.92 weeks(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) in group B (P < 0.001). Mean number of NBUVB sessions to which the patients were exposed was 17.05 ± 6.71 in group A and 34.05 ± 16.92 in group B (P < 0.0001).…”

mentioning

confidence: 98%

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Methotrexate/narrowband UVB phototherapy combination vs. narrowband UVB phototherapy in the treatment of chronic plaque‐type psoriasis – a randomized single‐blinded placebo‐controlled study

Mahajan

Kaur

Kanwar

2010

Acad Dermatol Venereol

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 98%

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Methotrexate/narrowband UVB phototherapy combination vs. narrowband UVB phototherapy in the treatment of chronic plaque‐type psoriasis – a randomized single‐blinded placebo‐controlled study

Mahajan

Kaur

Kanwar

2010

Acad Dermatol Venereol

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“…In open-label studies, topical bexarotene application also showed useful therapeutic activity in chronic serve hand-eczema [55] and mild-to-moderate plaque psoriasis [56]. In combination with narrowband UVB phototherapy, bexarotene gel was significantly more effective for the treatment of moderate-to-severe psoriasis vulgaris than narrowband UVB phototherapy alone [57]. A clinical benefit was also observed for alopecia areata in a phase I/II trial [58].…”

Section: Topical Usementioning

confidence: 99%

Retinoid treatment of skin diseases

Beckenbach

Baron

Merk

et al. 2015

European Journal of Dermatology

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Retinoid treatment of skin diseases Retinoids (vitamin A and its metabolites) are potent natural regulators of cellular activities, including cell growth and differentiation, and they mediate many essential regulatory functions, especially in the skin. Biologically active retinoids exert their effects by binding to nuclear retinoic acid receptors and retinoid-X-receptors. The group of pharmacologically used retinoids include naturally occurring and chemically synthesised vitamin A derivatives. Due to their influence on keratinocyte proliferation, epidermal differentiation and keratinisation, retinoids are commonly used in the field of dermatopharmacology. For safe administration of retinoids, in-depth information about adverse effects and comprehensive information of the patient are important. This article gives an overview on the effects, use, and side-effects of topical and systemic retinoids in dermatology.

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“…The expression profile of RXRs and their downstream signaling is altered in a variety of diseases including breast cancer [3] and viral hepatitis [4]. Correspondingly, RXR agonists are implicated in cancer prevention, antiviral therapy, dermatological disease, and metabolic syndromes [2], [5], [6]. Mediated via RXRs (α, β, and γ) and retinoic acid receptors (α, β, and γ), retinoic acid exerts its biological effects.…”

Section: Introductionmentioning

confidence: 99%

Function Annotation of Hepatic Retinoid x Receptor α Based on Genome-Wide DNA Binding and Transcriptome Profiling

Zhan

Fang

et al. 2012

PLoS ONE

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BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse livers, the current study identifies the bona-fide hepatic RXRα targets and biological pathways. In addition, based on binding and motif analysis, the molecular mechanism by which RXRα regulates hepatic genes is elucidated in a high-throughput manner.Principal FindingsClose to 80% of hepatic expressed genes were bound by RXRα, while 16% were expressed in an RXRα-dependent manner. Motif analysis predicted direct repeat with a spacer of one nucleotide as the most prevalent RXRα binding site. Many of the 500 strongest binding motifs overlapped with the binding motif of specific protein 1. Biological functional analysis of RXRα-dependent genes revealed that hepatic RXRα deficiency mainly resulted in up-regulation of steroid and cholesterol biosynthesis-related genes and down-regulation of translation- as well as anti-apoptosis-related genes. Furthermore, RXRα bound to many genes that encode nuclear receptors and their cofactors suggesting the central role of RXRα in regulating nuclear receptor-mediated pathways.ConclusionsThis study establishes the relationship between RXRα DNA binding and hepatic gene expression. RXRα binds extensively to the mouse genome. However, DNA binding does not necessarily affect the basal mRNA level. In addition to metabolism, RXRα dictates the expression of genes that regulate RNA processing, translation, and protein folding illustrating the novel roles of hepatic RXRα in post-transcriptional regulation.

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A randomized, double-blind, vehicle-controlled, bilateral comparison trial of bexarotene gel 1% versus vehicle gel in combination with narrowband UVB phototherapy for moderate to severe psoriasis vulgaris

Cited by 17 publications

References 6 publications

Methotrexate/narrowband UVB phototherapy combination vs. narrowband UVB phototherapy in the treatment of chronic plaque‐type psoriasis – a randomized single‐blinded placebo‐controlled study

Methotrexate/narrowband UVB phototherapy combination vs. narrowband UVB phototherapy in the treatment of chronic plaque‐type psoriasis – a randomized single‐blinded placebo‐controlled study

Retinoid treatment of skin diseases

Function Annotation of Hepatic Retinoid x Receptor α Based on Genome-Wide DNA Binding and Transcriptome Profiling

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