A Randomized Double-Blind Trial of Dextrose-Glycerine-Phenol Injections for Chronic, Low Back Pain

Klein, Robert G.; Eek, Bjorn; DeLong, W. Bradford; Mooney, Vert

doi:10.1097/00002517-199302000-00005

Cited by 137 publications

(73 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two additional RCTs were found (Dechow et al 1999, Klein et al 1993). These two papers referred to injections of sclerosants into ligaments, fascia and joint capsules of the back.…”

Section: Additional Rctsmentioning

confidence: 99%

“…The other high quality RCT (Klein et al 1993) compared a similar regimen of injections. 79 patients who failed to respond to previous conservative care were randomly assigned to receive a double blind series of six, once-weekly injections of either xylocaine/saline solution or xylocaine/proliferants (dextrose, 25%, glycerine, 25%, phenol, 2.4%) into the posterior sacroiliac and interspinous ligaments, fascia, and joint capsules of the low back from L4 to the sacrum.…”

Section: Effectiveness Effectiveness Versus a Sham Procedures (Injectimentioning

confidence: 99%

See 1 more Smart Citation

Chapter 4 European guidelines for the management of chronic nonspecific low back pain

Airaksinen¹,

Brox²,

Cedraschi³

et al. 2006

Eur Spine J

2,229

1,673

View full text Add to dashboard Cite

“…Two additional RCTs were found (Dechow et al 1999, Klein et al 1993). These two papers referred to injections of sclerosants into ligaments, fascia and joint capsules of the back.…”

Section: Additional Rctsmentioning

confidence: 99%

Section: Effectiveness Effectiveness Versus a Sham Procedures (Injectimentioning

confidence: 99%

Chapter 4 European guidelines for the management of chronic nonspecific low back pain

Airaksinen¹,

Brox²,

Cedraschi³

et al. 2006

Eur Spine J

2,229

1,673

View full text Add to dashboard Cite

“…16 Positive treatment effects from PrT have been documented in 34 case series and case reports on over 3,600 patients with a variety of chronic musculoskeletal pain conditions. 13 Seven randomized controlled trials have assessed PrT for low back pain, [17][18][19][20] OA, 21,22 and lateral epicondylosis. 23 Positive effects of PrT compared to control injections for low back pain have been reported 18,19 ; equivocal results have also been reported.…”

mentioning

confidence: 99%

“…13 Seven randomized controlled trials have assessed PrT for low back pain, [17][18][19][20] OA, 21,22 and lateral epicondylosis. 23 Positive effects of PrT compared to control injections for low back pain have been reported 18,19 ; equivocal results have also been reported. 17,20 Studies assessing PrT for OA report positive outcomes for knee OA 22 and equivocal results in finger/thumb joints.…”

mentioning

confidence: 99%

Early inflammatory response of knee ligaments to prolotherapy in a rat model

Jensen

Rabago

Best

et al. 2008

Journal Orthopaedic Research

115

View full text Add to dashboard Cite

Prolotherapy is an alternative injection-based therapy for chronic musculoskeletal pain. Three different proliferants, D-glucose (dextrose), phenol-glucose-glycerine (P2G), and sodium morrhuate, used in prolotherapy are hypothesized to strengthen and reorganize chronically injured soft tissue and decrease pain through modulation of the inflammatory process. Our hypothesis is that commonly used prolotherapy solutions will induce inflammation (leukocyte and macrophage infiltration) in medial collateral ligaments (MCLs) compared to needlestick, saline injection, and no-injection controls. MCLs of 84 Sprague-Dawley rats were injected one time at both the tibial and femoral insertions. Immunohistochemistry (IHC) was used to determine the inflammatory response at three locations (tibial and femoral insertions and midsubstance) 6, 24, and 72 h after dextrose injection compared to saline-and no-injection controls and collagenase (positive control) (n ¼ 4). qPCR was used to analyze gene expression 24 h postinjection (n ¼ 4). Sodium morrhuate, P2G, and needlestick control were also investigated after 24 h (n ¼ 4). In general, inflammation (CD43þ, ED1þ, and ED2þ cells) increased after prolotherapy injection compared to no-injection control but did not increase consistently compared to saline and needlestick control injections. This response varied by both location and proliferant. Inflammation was observed at 6 and 24 h postinjection but was resolved by 72 h compared to no-injection controls (p < 0.05). CD43þ leukocytes and ED2þ macrophages increased compared to needlestick and saline-injection control, respectively, 24 h postinjection (p < 0.05). Prolotherapy injections created an inflammatory response, but this response was variable and overall, not uniformly different from that caused by saline injections or needlestick procedures. ß

show abstract

“…12,13 Finding of sacroiliac joint dysfunction is indicative of damage to ligaments or the low back. [14][15][16] Research has indicated that most patients with lumbar pain do not have neurological problems but back pain usually results from injury related to the soft tissues. 17 The patient and her doctor both noted positive objective and subjective improvements from the onset of the active patient rehabilitation program.…”

Section: Discussionmentioning

confidence: 99%

Treatment of chronic low back pain incorporating active patient participation and chiropractic: a retrospective case report

Legier

2005

Journal of Chiropractic Medicine

View full text Add to dashboard Cite

show abstract

A Randomized Double-Blind Trial of Dextrose-Glycerine-Phenol Injections for Chronic, Low Back Pain

Cited by 137 publications

References 0 publications

Chapter 4 European guidelines for the management of chronic nonspecific low back pain

Chapter 4 European guidelines for the management of chronic nonspecific low back pain

Early inflammatory response of knee ligaments to prolotherapy in a rat model

Treatment of chronic low back pain incorporating active patient participation and chiropractic: a retrospective case report

Contact Info

Product

Resources

About