A randomized, double-blind, placebo-controlled trial of Chinese herbal medicine granules for the treatment of menopausal symptoms by stages

Fu, Sun; Zhao, Yingqiang; Ren, Ming; Zhang, Junhua; Wang, Yuefei; Han, Lifeng; Chang, Yan‐xu; Fan, Guanwei; Wang, Hong; Huang, Yühong; Zhai, Jing; Dong, Jinying; Li, Xin; Ai, Ju-qing; Zhang, Han; Zhu, Yan; Zhang, Boli; Sun, Li; Fan, Xitao; Gao, Xiumei

doi:10.1097/gme.0000000000000534

Cited by 23 publications

(27 citation statements)

References 46 publications

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“…There are multiple treatment options other than MHT proposed by different authors for menopausal symptoms. Fu et al conducted a randomized trial on usage of Chinese herbal medicine among patients with menopause and they found significant improvement in vasomotor symptoms after 8 weeks of usage of herbal granules [20]. In another study by Nourozi et al, Soy milk ingestion was compared with low fat cow milk.…”

Section: Number Of Patients Percentagementioning

confidence: 99%

Quality of Life after Menopause in Pakistani Women

Waheed¹,

Khanum²,

Ejaz³

et al. 2015

Gynecol Obstet

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Background: With the increase in life expectancy of women all over the world, women are expected to spend almost 1/3rd of their life in menopause phase, usually starting in 4th to 5th decade of life.Objective: This study was planned to look for quality of life of women during menopause in Pakistan. Material and methods:This cross-sectional study was conducted at Gynaecology and Obstetrics department of Lady Atchison Hospital, Lahore over a period of 3 months from June, 2015 to August, 2015. Menopause-Specific Quality of Life Questionnaire (MENQOL) was distributed among 120 patients with the age range of 51-80 years presenting in Outdoor department of the institution. All the demographic details and MenQol results were analyzed. Also Odd's ratio (OR) was calculated for these symptoms according to age groups of the patients. Results:The mean age of the patients was 60 ± 5.8 years. The mean age of patients at time of menarche was calculated as 13.4 ± 1.80 years and the mean age at menopause was 49.10 ± 3.98 years. We found that the most common symptom of the patients in our study was low backache and the least reported symptom was drying skin.

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Section: Number Of Patients Percentagementioning

confidence: 99%

Quality of Life after Menopause in Pakistani Women

Waheed¹,

Khanum²,

Ejaz³

et al. 2015

Gynecol Obstet

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“…Hence, ovarian dysfunction during perimenopause leads to reduced production of E 2 and abnormal lipid metabolism. Previous studies have demonstrated that the Chinese herbal medicine preparation Jiawei Qing'e Fang reduces hot flushes, improves menopausal symptoms and has a potential advantage in reducing triglyceride levels (Fu et al 2016). Therefore, the discovery of drugs that are effective against ovarian dysfunction and dyslipidaemia will be a groundbreaking discovery in the pursuit of effective management to improve ovarian function and lipid metabolism (Yoshihisa et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…This underscores the need to improve ovarian function and attenuate the morbidity and mortality associated with lipid dysregulation in perimenopausal women (Sanada et al 2002;Ho et al 2010). Available reports indicate that the DZQE formula improves the quality of life for menopausal women, especially for those with hot flush symptoms thorughout the menopausal period (Fu et al 2016). Both in vivo and in vitro experiments have proved the efficacy of natural compounds, suggesting that studies on natural compounds that improve oestrogen levels make substantial impact.…”

Section: Introductionmentioning

confidence: 99%

“…Both in vivo and in vitro experiments have proved the efficacy of natural compounds, suggesting that studies on natural compounds that improve oestrogen levels make substantial impact. Previous studies have demonstrated that the Chinese herbal medicine preparation Jiawei Qing'e Fang reduces hot flushes, improves menopausal symptoms and has a potential advantage in reducing triglyceride levels (Fu et al 2016). Danzhi Qing'e is produced from Jiawei Qing'e Fang by adding an active ingredient.…”

Section: Introductionmentioning

confidence: 99%

“…Danzhi Qing'e is produced from Jiawei Qing'e Fang by adding an active ingredient. Available reports indicate that the DZQE formula improves the quality of life for menopausal women, especially for those with hot flush symptoms thorughout the menopausal period (Fu et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Danzhi Qing'e (DZQE) activates AMPK pathway and regulates lipid metabolism in a rat model of perimenopausal hyperlipidaemia

Asare

Wang

et al. 2016

Experimental Physiology

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What is the central question of this study? Does Danzhi Qing'e (DZQE) regulate lipid metabolism and improve ovarian function in a rat model of perimenopausal hyperlipidaemia, and could this effect be mediated through the AMPK pathway? What is the main finding and its importance? We revealed that DZQE is a pharmacotherapy that could activate the AMPK pathway to improve ovarian function and lipid metabolism during perimenopause complicated with hyperlipidaemia syndrome in an animal model. Thus, this study provides a novel therapeutic option for treating perimenopausal syndrome and highlights the therapeutic potential of DZQE in perimenopausal rats. Menopause is an important event in a woman's life. During perimenopause, accompanied by development of osteoporosis and dyslipidaemia, ovarian function gradually declines. Dyslipidaemia is a risk factor for cardiovascular disorders, cerebrovascular disease and breast cancer in postmenopausal women. All of these contribute to impairment of liver function, particularly fatty liver disease, because liver dysfunction is associated with ovarian dysfunction and hyperlipidaemia. The aim of this study was to define a therapeutic approach to improve ovarian function and attenuate lipid accumulation in order to prevent perimenopause-induced ovarian dysfunction and hyperlipidaemia. Four-week-old female Wistar rats were injected i.p. with 4-vinylcyclohexene diepoxide (4-VCD) and fed with a high-fat diet (HFD) to serve as a model of perimenopause complicated with hyperlipidaemia. The 4-VCD induces perimenopause, while the HFD causes hyperlipidaemia. Five days after administration of 4-VCD, the 4-VCD + HFD-treated rats were assessed daily for oestrous cycle stage by vaginal cytology. Rats were then assigned into groups, in which 2.5, 5.0 or 10.0 g kg Danzhi Qing'e (DZQE) or estradiol valerate was administered intragastrically for 8 weeks. Expression levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestrogen and testosterone measured by enzyme-linked immunosorbent assay served as biomarkers for perimenopause and ovarian dysfunction. The expression levels of AMPK and acetyl-CoA carboxylase in the liver were determined with Western blotting, and aspartate aminotransferase and alanine aminotransferase were analysed using an automated biochemical analyser to examine liver function. The DZQE improved ovarian function by upregulating oestrogen and testosterone concentrations in serum and downregulating FSH and LH serum concentrations. Moreover, DZQE reduced serum concentrations of triglyceride, total cholesterol and low-density lipoprotein in a dose-dependent manner to regulate lipid levels during perimenopause. Furthermore, DZQE increased AMPK at both the transcriptional and translational levels and decreased the expression of SREBP-1c gene as well as its downstream target gene, fatty acid synthase. Danzhi Qing'e improved dyslipidaemia during menopause and also had an effect on liver function. Danzhi Qing'e is an effective Chinese herbal compound, which improves ovari...

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